
Dr. Kirstin Scherlach
Biomolecular Chemistry · Postdoc
Phone: +49 3641 532-1034 Fax: +49 3641 532-2034 Email: kirstin.scherlach@leibniz-hki.de
(2021) N-heterocyclization in gliotoxin biosynthesis is catalyzed by a distinct cytochrome P450 monooxygenase. Chembiochem 22(2), 336-339. Details PubMed Open Access PDF
(2020) Food-poisoning bacteria employ a citrate synthase and a type II NRPS to synthesize bolaamphiphilic lipopeptide antibiotics. Angew Chem Int Ed 59(48), 21535-21540. Details PubMed Open Access PDF
(2020) Lichen-like association of Chlamydomonas reinhardtii and Aspergillus nidulans protects algal cells from bacteria. ISME J 14(11), 2794-2805. Details PubMed Open Access
(2020) Chemical mediators at the bacterial-fungal interface. Annu Rev Microbiol 74, 267-290. Details PubMed
(2020) Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. eLife 9, e52541. Details PubMed Open Access PDF
(2019) Antifungal potential of secondary metabolites involved in the interaction between citrus pathogens. Sci Rep 9(1), 18647. Details PubMed Open Access PDF
(2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19. Details PubMed Open Access PDF
(2019) Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolase. Cell Chem Biol 26(4), 524-534. Details PubMed Open Access PDF
(2019) Genome mining reveals endopyrroles from a nonribosomal peptide assembly line triggered in fungal-bacterial symbiosis. ACS Chem Biol 14(8), 1811-1818. Details PubMed
(2018) Unexpected bacterial origin of the antibiotic icosalide: Two-tailed depsipeptide assembly in multifarious Burkholderia symbionts. ACS Chem Biol 13(9), 2414-2420. Details PubMed
(2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. eLife 7, e40969. Details PubMed Open Access
(2018) An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles. Nat Commun 9(1), 2478. Details PubMed Open Access
(2018) Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nat Commun 9(1), 2208. Details PubMed Open Access
(2018) Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria. Sci Rep 8(1), 15859. Details PubMed Open Access PDF
(2018) Genomics-driven discovery of a symbiont-specific cyclopeptide from bacteria residing in the rice seedling blight fungus. ChemBioChem 19(20), 2167-2172. Details PubMed
(2018) Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria. Org Biomol Chem 16(37), 8345-8352. Details PubMed
(2018) Reconstitution of enzymatic carbon-sulfur bond formation reveals detoxification-like strategy in fungal toxin biosynthesis. ACS Chem Biol 13(9), 2508-2512. Details PubMed
(2018) Mediators of mutualistic microbe-microbe interactions. Nat Prod Rep 35(4), 303-308. (Review) Details PubMed
(2018) Two types of threonine-tagged lipopeptides synergize in host colonization by pathogenic Burkholderia species. ACS Chem Biol 13(5), 1370-1379. Details PubMed
(2018) Enzymatic amide tailoring expedites unusual retro-aldol-type amino acid conversion to form antifungal cyclopeptide. Angew Chem Int Ed 57(43), 14051-14054. Details PubMed
(2017) Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism. Nat Commun 8, 15172. Details PubMed
(2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882. Details PubMed
(2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617. Details PubMed
(2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement
(2016) Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angew Chem Int Ed 55(39), 11955-11959. Details PubMed
(2016) Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061. Carbohydr Res 433, 31-35. Details PubMed
(2016) Structural and conformational study of the O‐antigenic portion of the Lipopolysaccharide isolated from Burkholderia gladioli pv. cocovenenans. Eur J Org Chem 4, 748-755. Details
(2016) Food preparation with mucoralean fungi: A potential biosafety issue? Fungal Biol 120(3), 393-401. Details PubMed
(2016) Draft genome sequences of fungus Aspergillus calidoustus. Genome Announc 4(2), e00102-16. Details PubMed
(2016) HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence. PLOS ONE 11(3), e0150701. Details PubMed
(2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio 6(2), e00143. Details PubMed
(2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162. Details PubMed
(2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. Details PubMed
(2014) Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus. Mycoses 57, 48-55. Details PubMed
(2014) The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria. Angew Chem Int Ed Engl 53(30), 7794-7798. Details PubMed
(2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109. Details PubMed
(2013) Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. J Am Chem Soc 135(46), 17408-17416. Details PubMed
(2012) A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat Chem Biol 8(2), 154-161. Details PubMed
(2012) Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli. Chem Biol 19(9), 1164-1174. Details PubMed Open Access PDF
(2012) Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Org Biomol Chem 10(30), 5756-5759. Details PubMed
(2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618. Details PubMed
(2011) Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. Chem Biol 18(2), 198-209. Details PubMed
(2011) Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives. ChemMedChem 6(11), 1998-2001. Details PubMed
(2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287. Details PubMed
(2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325. Details PubMed
(2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42), 9843-9847. Details PubMed
(2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839. Details PubMed
(2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5), 2508-2524. Details PubMed
(2010) Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa. Phytochemistry 71(1), 110-116. Details PubMed
(2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24), 8143-8149. Details PubMed Open Access PDF Supplement
(2010) Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line. Angew Chem Int Ed Engl 49(8), 1460-1464. Details PubMed
(2010) Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli. Org Biomol Chem 8(7), 1520-1522. Details PubMed
(2010) Toxin production by bacterial endosymbionts of a Rhizopus microsporus strain used for tempe/sufu processing. Int J Food Microbiol 136(3), 368-371. Details PubMed
(2010) The chemistry and biology of cytochalasans. Nat Prod Rep 27(6), 869-886. Details PubMed
(2010) Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans. J Antibiot (Tokyo) 63(7), 375-377. Details PubMed
(2009) Polyketide-chain branching by an enzymatic Michael addition. Angew Chem Int Ed Engl 48(27), 5001-5004. Details PubMed
(2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986. Details PubMed
(2009) Triggering cryptic natural product biosynthesis in microorganisms. Org Biomol Chem 7(9), 1753-1760. Details PubMed
(2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34), 14558-14563. Details PubMed
(2008) Activation of fungal silent gene clusters: a new avenue to drug discovery. Prog Drug Res 66, 1, 3-1,12. Details PubMed
(2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4), 213-217. Details PubMed
(2007) A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex. Org Biomol Chem 5(14), 2211-2213. Details PubMed
(2006) The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin. J Am Chem Soc 128(45), 14619-14624. Details PubMed
(2006) Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org Biomol Chem 4(18), 3517-3520. Details PubMed
(2006) Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. J Am Chem Soc 128(35), 11529-11536. Details PubMed