Curriculum vitae

Main Research Areas
  • Topic of the PhD thesis: "Agent-based modelling of the spatio-temporal interaction between immune cells and human-pathogenic fungi"
  • agent-based modelling and simulation of host-pathogen interactions
  • interaction of immune cells and Candida albicans in human blood
  • migration dynamics of immune cells as a consequence of fungal infections
Professional Career
since 2018 Postdoctoral researcher in the group Applied Systems Biology at Hans Knöll Institute
2018 PhD in Bioinformatics at the Friedrich Schiller University Jena
2013 M.Sc. in Bioinformatics at the Friedrich Schiller University Jena
2011 B.Sc. in Bioinformatics at the Friedrich Schiller University Jena

Publications

Timme S*, Wendler S*, Klassert TE, Saraiva JP, Nunes da Rocha U, Wittchen M, Schramm S, Ehricht R, Monecke S, Edel B, Rödel J, Löffler B, Soledad Ramirez M, Slevogt H, Figge MT*#, Tuchscherr L*# (2024) Competitive inhibition and mutualistic growth in co-infections: Deciphering Staphylococcus aureusAcinetobacter baumannii interaction dynamics. ISME Commun 4(1), ycae077.
Valentine M*, Rudolph P*, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS*#, Hube B*# (2024) Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis. mBio 15(3), e0340923.
Saffer C, Timme S, Rudolph P, Figge MT# (2023) Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections. NPJ Syst Biol Appl 9, 12.
Engels G, Forster J, Streng A, Rücker V, Rudolph P, Pietsch F, Wallstabe J, Wallstabe L, Krauthausen M, Schmidt J, Ludwig T, Bauer C, Gierszewski D, Bendig J, Timme S, Jans T, Weißbrich B, Romanos M, Dölken L, Heuschmann P, Härtel C, Gágyor I, Figge MT, Liese J, Kurzai O (2022) Acceptance of different self-sampling methods for semiweekly SARS-CoV-2 testing in asymptomatic children and childcare workers at German Day Care Centers: A nonrandomized controlled trial. JAMA Netw Open 5(9), e2231798.
Forster J, Streng A, Rudolph P, Rücker V, Wallstabe J, Timme S, Pietsch F, Hartmann K, Krauthausen M, Schmidt J, Ludwig T, Gierszewski D, Jans T, Engels G, Weißbrich B, Romanos M, Dölken L, Heuschmann P, Härtel C, Gágyor I, Figge MT, Kurzai O, Liese J (2022) Feasibility of SARS-CoV-2 surveillance testing among children and childcare workers at German Day Care Centers: A nonrandomized controlled trial. JAMA Netw Open 5(1), e2142057.
Lehnert T*, Leonhardt I*, Timme S, Thomas-Rüddel D, Bloos F, Sponholz C, Kurzai O, Figge MT#, Hünniger K# (2021) Ex vivo immune profiling in patient blood enables quantification of innate immune effector functions. Sci Rep 11(1), 12039.
Blickensdorf M, Timme S, Figge MT (2020) Hybrid agent-based modeling of Aspergillus fumigatus infection to quantitatively investigate the role of Pores of Kohn in human alveoli. Front Microbiol 11, 1951.
Blickensdorf M, Timme S, Figge MT (2019) Comparative assessment of aspergillosis by virtual infection modeling in murine and human lung. Front Immunol 10, 142.
Prauße MTE, Lehnert T, Timme S, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560.
Timme S, Lehnert T, Prauße MTE, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667.