
Prof. Dr. Bernhard Hube
Microbial Pathogenicity Mechanisms
Phone: +49 3641 532-1401 Fax: +49 3641 532-0810 Email: bernhard.hube@leibniz-hki.de
- Infection biology of human pathogenic fungi (Candida albicans, C. glabrata)
- Host-/pathogen-interactions
- Functional genomics and micro-evolution
- Infection-associated genes
Professional Career
Since 2007 | Head, Dept. Microbial Pathogenicity Mechanisms, HKI Jena |
Since 2006 | Professor (W3), Chair in Microbial Pathogenicity, FSU Jena |
2006-2007 | Head of the division FG16 “Mycology”, RKI Berlin |
2000-2006 | Lecturer in Microbiology, FU Berlin |
2000-2006 | Head of a research group, RKI Berlin |
2000 | Habilitation in Molecular Microbiology, University of Hamburg |
1996-2000 | Assistant Professor (C1), Applied Molecular Biology, University of Hamburg |
1995-1996 | Research Assistant, Applied Molecular Biology, University of Hamburg |
1992-1995 | Honour Research Fellow, EG- and DFG-funded, University of Aberdeen, United Kingdom |
1991 | Dr. rer. nat. in Microbiology, University of Göttingen |
1986 | Diploma in Biology, University of Göttingen, Germany |
Awards · Appointments · Scientific Activities
2017 | “Drug of the Year” Award of the Leibniz Association |
Since 2015 | Coordinator and PI, Infect-ERA-Consortium "FunComPath" |
Since 2015 | Member of the board, ZIK Septomics |
2014 | Main award of DGHM |
Since 2013 | Steering committee and PI, SFB/Transregio FungiNet (DFG) |
Since 2013 | International project advisory board “MICRODEV - Role of developmental processes in the virulence of human pathogens: from molecular mechanisms to novel therapeutic targets” (Belgium) |
Since 2013 | Honorary member of the DMykG |
2013-2015 | Co-chair, Gordon Conference “Immunology of Fungal Infections” |
2013 | Member of the programme committee, ASM Candida and Candidiasis Meeting 2014 |
2013 | Co-Organisation of the FEBS advanced course "State-of-the-art infection models for human pathogenic fungi", Jena |
2012-2015 | “In house professorship”, Center for Sepsis Control and Care (CSCC), Integriertes Forschungs- und Behandlungszentrum (IFB), Jena |
Since 2012 | Scientific advisory board Wellcome Trust Strategic Award (WTSA) “Medical Mycology and Fungal Immunology”, Aberdeen, UK |
2011-2013 | Co-vice chair, Gordon Conference “Immunology of Fungal Infections” |
2011 | Organisation of the international FINSysB research skills training workshop “State-of-the-art infection models” |
Since 2010 | Steering Committee, International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS) |
2010-2012 | Co-chair and member of the programme and organisation committee "ISHAM 2012“ |
2009 | Vice President of the International Society for Human and Animal Mycology (ISHAM) |
Since 2009 | Science advisory board of the FEBS advanced course on Human Fungal Pathogens |
Since 2008 | Fellow at the American Academy of Microbiology (AAM) |
2008 | Heinz-Maurer-Award (co-author) |
Since 2007 | PI at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS) |
Since 2007 | PI at the excellence school Jena School for Microbial Communications (JSMC) |
2007-2016 | Eight science awards of the DMykG (as author and co-author) |
2005 | Scientific committee “Interdisciplinary Forum on Candida and Candida Infections” in Göttingen |
2005 | Local scientific committee TIMM 2005 (“Trends in Medical Mycology“) in Berlin |
2004-2006 | Science advisory board of the “FEBS advanced course on Human Fungal Pathogens“ |
2003-2006 | Chairman of the section "Eukaryotic Pathogens“ of the DGHM |
2003 | Heinz Seeliger Award |
2003 | Becton Dickinson Award of the DGHM |
2002-2003 | Secretary of the section "Eukaryotic Pathogens“ of the DGHM |
Since 2000 | Reviewer for Grant & Fellowship Applications: Health and Medical Research Fund China (HMRF), Health and Medical Research Fund (HMRF), Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Swiss National Science foundation (SNF), UK-India Education and Research Initiative (UKIERI), i-Move (EU), Agence Nationale de la Rechere France (ANR), Robert Koch Institute (RKI), National Science Centre Poland (NSCP), Biotechnology and Biological Sciences Research Council (BBSRC), Deutsche Forschungsgemeinschaft (DFG), Deutsch-Israelische Stiftung für Wissenschaftliche Forschung und Entwicklung (GIF), European Molecular Biology Organization (EMBO), Medical Research Council (MRC), National Science Foundation (NSF, USA), Netherlands Organisation for Scientific Research (NWO), Research Foundation-Flanders/Fonds Wetenschappelijk Onderzoek (FWO, Belgien), The Royal Society (London, UK), The Welcome Trust, Foundation for Polish Science (FNP), European Molecular Biology Conference (EMBC), Studienstiftung des Deutschen Volkes, Bundesministeriums für Bildung und Forschung (BMBF), British Society for Antimicrobial Chemotherapy (BSAC), Evaluation of grant proposals and promotions for multiple international universities, Humboldt Stiftung, Deutsche Krebshilfe and others |
Since 2000 | PI in EU-Projects (Framework Programme 5, 6, 7) |
Since 2000 | Editorial Board / Associate Editor of mBio, Cellular Microbiology, Microbiology (SGM), BMC Microbiology, FEMS Yeast Research, F1000, Frontiers in Fungi and Their Interactions, Current Medical Mycology, Frontiers in Molecular Innate Immunity, Current Opinion in Microbiology (Section Editor 2009), Virulence |
1998 | Research funding award of the DMykG |
Since 1995 | Reviewer for more than 35 journals |
1992-1995 | Postdoc fellowships from the EG and DFG |
(2021) Experimental evolution of Candida by serial passaging in host cells. Methods Mol Biol 2260, 145-154. Details PubMed
(2021) Candida albicans Interaction with oral epithelial cells: Adhesion, invasion and damage assays. Methods Mol Biol 2260, 133-143. Details PubMed
(2020) Wettrüsten zwischen Pilz und Wirt. BIOSpektrum 26(3), 280-286. Details PubMed PDF
(2020) Characterization of a Candida albicans mutant defective in all MAPKs highlights the major role of hog1 in the MAPK signaling network. J Fungi (Basel) 6(4), E230. Details PubMed Open Access
(2020) Candida albicans Mrv8, is involved in epithelial damage and biofilm formation. FEMS Yeast Res 20(5), foaa033. Details PubMed Open Access PDF
(2020) The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev [Epub ahead of print] Details PubMed
(2020) Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. Cells 9(3), 699. Details PubMed Open Access PDF
(2020) Candida albicans adhesion to central venous catheters: Impact of blood plasma-driven germ tube formation and pathogen-derived adhesins. Virulence 11(1), 1453-1465. Details PubMed
(2020) Survival strategies of pathogenic Candida species in human blood show independent and specific adaptations. mBio 11(5), e02435-20. Details PubMed
(2020) The dual Function of the fungal toxin candidalysin during Candida albicans-macrophage interaction and virulence. Toxins 12(8), 469. Details PubMed Open Access PDF
(2020) Fungal factors involved in host immune evasion, modulation and exploitation during infection. Cell Microbiol 23(1), e13272. Details PubMed Open Access PDF
(2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15. Details PubMed
(2020) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J [Epub ahead of print] Details PubMed Open Access
(2020) Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11(2), e00206-20. Details PubMed Open Access PDF
(2020) Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome 8(1), 133. Details PubMed Open Access PDF
(2020) A TRP1-marker-based system for gene complementation, overexpression, reporter gene expression, and gene modification in Candida glabrata. FEMS Yeast Res 20(8), foaa066. Details PubMed Open Access
(2020) Fungal biotin homeostasis is essential for immune evasion after macrophage phagocytosis and virulence. Cell Microbiol 22(7), e13197. Details PubMed Open Access PDF
(2020) Lysosome fusion maintains phagosome integrity during fungal infection. Cell Host Microbe S1931-3128(20), 30505-9. Details PubMed
(2019) Recent trends in molecular diagnostics of yeast infections: from PCR to NGS. FEMS Microbiol Rev 43(5), 517-547. Details PubMed Open Access
(2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6), 1340-1355. Details PubMed Open Access PDF
(2019) The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. J Hepatol 72(3), 391-400. Details PubMed
(2019) Cooperative role of MAPK pathways in the interaction of Candida albicans with the host Epithelium. Microorganisms 8(1), 48. Details PubMed Open Access PDF
(2019) CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nat Immunol 20(5), 559-570. Details PubMed Open Access PDF
(2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19. Details PubMed Open Access PDF
(2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), dmm039719. Details PubMed Open Access PDF
(2019) Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nat Commun 10(1), 2297. Details PubMed Open Access PDF
(2019) Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis. Protein Sci 29(2), 480-493. Details PubMed
(2019) RNAi as a tool to study virulence in the pathogenic yeast Candida glabrata. Front Microbiol 10, 1679. Details PubMed Open Access PDF
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. Details PubMed
(2019) Candidalysin: Discovery and function in Candida albicans infections. Curr Opin Microbiol 52, 100-109. Details PubMed Open Access PDF
(2019) Host-pathogen interactions during female genital tract infections. Trends Microbiol 27(12), 982-996. (Review) Details PubMed
(2019) Antivirulence and avirulence genes in human pathogenic fungi. Virulence 10(1), 935-947. Details PubMed Open Access PDF
(2019) Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection. J Infect Dis 220(9), 1477-1488. Details PubMed Open Access PDF
(2019) Integrity under stress: Host membrane remodelling and damage by fungal pathogens. Cell Microbiol 21(4), e13016. Details PubMed Open Access PDF
(2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3), e00915. Details PubMed Open Access
(2018) The needle and the damage done. Nat Microbiol 3(8), 860-861. (Review) Details PubMed
(2018) Biphasic zinc compartmentalisation in a human fungal pathogen. PLOS Pathog 14(5), e1007013. Details PubMed Open Access
(2018) Metals in fungal virulence. FEMS Microbiol Rev 42(1), fux050. (Review) Details PubMed Open Access
(2018) Candida species. In: Oxford University Press (ed.) Oxford Textbook of Medical Mycology Chapter 11, pp. 77-79. Oxford University Press. ISBN: 978019875. (Review) Details
(2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun 9(1), 4260. Details PubMed Open Access
(2018) Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence. mBio 9(1), e02178-17. Details PubMed Open Access PDF
(2018) Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa. Infect Immun 86(2), e00645-17. Details PubMed Open Access PDF
(2018) Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha. Eur J Immunol 48(11), 1826-1837. Details PubMed Open Access PDF
(2018) Metabolic adaptation of intracellular bacteria and fungi to macrophages. Int J Med Microbiol 308(1), 215-227. (Review) Details PubMed Open Access
(2018) Editorial: Immunity to human fungal pathogens: Mechanisms of host recognition, protection, pathology, and fungal interference. Front Immunol 9, 2337. Details PubMed Open Access PDF
(2018) IL-36 and IL-1/IL-17 drive immunity to oral candidiasis via parallel mechanisms. J Immunol 201(2), 627-634. Details PubMed Open Access PDF
(2018) Candida albicans hyphal expansion causes phagosomal membrane damage and luminal alkalinization. mBio 9(5), e01226-18. Details PubMed Open Access PDF
(2017) The fungal pathogen Candida glabrata does not depend on surface ferric reductases for iron acquisition. Front Microbiol 8, 1055. Details PubMed Open Access
(2017) Candida albicans morphology: still in focus. Expert Rev Anti Infect Ther 15(4), 327-330. (Review) Details PubMed Open Access
(2017) Fungi that infect humans. Microbiol Spectr 5(3), FUNK-0014-2016. (Review) Details PubMed
(2017) Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLOS ONE 12(10), e0184438. Details PubMed Open Access
(2017) Zinc limitation induces a hyper-adherent goliath phenotype in Candida albicans. Front Microbiol 8, 2238. Details PubMed Open Access
(2017) Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol 40, 104-112. (Review) Details PubMed
(2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617. Details PubMed
(2017) The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans. Mol Microbiol 104(6), 989-1007. Details PubMed
(2017) Candida albicans Hap43 domains are required under iron starvation but not excess. Front Microbiol 8, 2388. Details PubMed Open Access
(2017) Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Sci Immunol 2(17), pii: eaam8834. Details PubMed
(2017) When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi. Virulence 8(7), 1435-1444. (Review) Details PubMed Open Access
(2016) In vivo transcriptional profiling of human pathogenic fungi during infection: reflecting the real life? PLOS Pathog 12(4), e1005471. (Review) Details PubMed Open Access
(2016) Candida species rewired hyphae developmental programs for chlamydospore formation. Front Microbiol 7, 1697. Details PubMed Open Access
(2016) Virulence factors in fungal pathogens of man. Curr Opin Microbiol 32, 89-95. (Review) Details PubMed Open Access
(2016) Aspartyl proteinases of eukaryotic microbial pathogens: From eating to heating. PLOS Pathog 12(12), e1005992. (Review) Details PubMed Open Access
(2016) Enemies and brothers in arms: Candida albicans and gram-positive bacteria. Cell Microbiol 18(12), 1709-1715. (Review) Details PubMed
(2016) In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence 7(7), 819-825. Details PubMed Open Access
(2016) A novel hybrid iron regulation network combines features from pathogenic and non-pathogenic yeasts. mBio 7(5), e01782-16. Details PubMed Open Access
(2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055. Details PubMed Open Access PDF
(2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54(3), 149-169. (Review) Details PubMed
(2016) Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells. Microbiology 162(12), 2116-2125. Details PubMed
(2016) Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence. Biochem J 473(11), 1537-1552. Details PubMed Open Access
(2016) Interdisziplinäres Forum zu Virulenzmechanismen phyto- und humanpathogener Pilze. In: Springer Spektrum (ed.) BIOspektrum IFO-Fun 2016: Interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi, Erlangen, 10/05/2016-10/07/2016, 7-2016, pp. 742.Springer-Verlag GmbH, Heidelberg. (Review) Details
(2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406. Details PubMed
(2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68. Details PubMed Open Access
(2016) Widespread inter- and intra-Ddmain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Front Microbiol 7, 2001. Details PubMed Open Access
(2016) The missing link between Candida albicans hyphal morphogenesis and host cell damage. PLOS Pathog 12(10), e1005867. (Review) Details PubMed
(2016) Global identification of biofilm-specific proteolysis in Candida albicans. mBio 7(5), e01514-16. Details PubMed Open Access
(2015) Csr1/Zap1 maintains zinc homeostasis and influences virulence in Candida dubliniensis but is not coupled to morphogenesis. Eukaryot Cell 14(7), 661-670. Details PubMed Open Access PDF
(2015) Of mice, flies - and men? Comparing fungal infection models for large-scale screening efforts. Dis Model Mech (8), 473-486. Details PubMed Open Access PDF
(2015) Induction of Caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect Immun 83(5), 1940-1948. Details PubMed
(2015) Virulence profile: Bernhard Hube. Virulence 6(5), 523-525. (Review) Details PubMed
(2015) Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. J Mycol Med 25(1), e44-e58. Details PubMed
(2015) Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase, and morphology. J Med Microbiol 64, 714-723. Details PubMed
(2015) Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence. FEMS Yeast Res 15(5), fov042. Details PubMed
(2015) Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence. PLOS One 10(3), e0122382. Details PubMed Open Access PDF
(2015) Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice. MBio 6(3), e00724. Details PubMed Open Access PDF
(2015) Candida survival strategies. Adv Appl Microbiol 91, 139-235. Details PubMed
(2014) Adaptive prediction as a strategy in microbial infections. PLOS Pathog 10(10), e1004356. Details PubMed Open Access
(2014) One small step for a yeast - Microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation. PLOS Pathog 10(10), e1004478. Details PubMed Open Access
(2014) Histidine degradation via an aminotransferase increases the nutritional flexibility of Candida glabrata. Eukaryot Cell 13(6), 758-765. Details PubMed
(2014) Metabolism in Fungal Pathogenesis. Cold Spring Harb Perspect Med 4(12), Details PubMed
(2014) Fine-scale chromosomal changes in fungal fitness. J Curr Fungal Infect Rep Vol. 8(2), 171-178. (Review) Details
(2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 12(7), 867-879. (Review) Details PubMed
(2014) Clotrimazol bei C. albicans-Infektionen. Dem Wirkmechanismus auf der Spur. Frauenarzt (4/14), 370-372. (Review) Details
(2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796. Details PubMed
(2014) Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLOS One 9(5), e96015. Details PubMed Open Access
(2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed
(2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 52(3), 223-239. Details PubMed
(2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 44(8), 2405-2414. Details PubMed
(2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PLOS One 9(3), e92734. Details PubMed Open Access
(2014) Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLOS Pathog 10(6), e1004211. Details PubMed Open Access
(2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13(1), 170-183. Details PubMed
(2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis 209(4), 616-626. Details PubMed
(2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLOS Genet 10(12), e1004824. Details PubMed Open Access
(2014) From commensal to pathogen: Candida albicans. In: Esser K, Kurzai O (eds.) The Mycota Ed. 2. Vol. XII, pp. 3-18. Springer Verlag. Details
(2014) Distinct roles of Candida albicans-specific genes in host-pathogen interactions. Eukaryot Cell 13(8), 977-989. Details PubMed
(2013) Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol 15(5), 701-708. (Review) Details PubMed Open Access
(2013) Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell 12(4), 604-613. Details PubMed
(2013) Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney. PLOS One 8(5), e64482. Details PubMed Open Access
(2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLOS One 8(3), e58613. Details PubMed Open Access
(2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. PLOS One 8(3), e60417. Details PubMed
(2013) Candida albicans pathogenicity mechanisms. Virulence 4(2), 119-128. (Review) Details PubMed
(2013) Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol 202(3), 183-195. (Review) Details PubMed
(2013) Limitation of (1→3)-β-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass. Crit Care 17(3), 437. Details PubMed
(2013) Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis. PLOS One 8(4), e61940. Details PubMed
(2013) Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol 43(3), 679-692. Details PubMed
(2013) A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. J Invest Dermatol 133(1), 144-153. Details PubMed
(2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother 57(10), 5178-5180. Details PubMed
(2012) Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol 42(4), 993-991004. Details PubMed
(2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777. Details PubMed Open Access
(2012) Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol 15(4), 406-412. (Review) Details PubMed
(2012) Embryonated chicken eggs as alternative infection model for pathogenic fungi. In: Brand AC, MacCallum DM (eds.) Methods in Molecular Biology. Host-fungus interactions. Methods and Protocols. 845, pp. 487-496. Humana Press (Springer). Details PubMed
(2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10(1), 85-93. (Review) Details PubMed
(2012) Transcriptomics in human blood incubation reveals the importance of oxidative stress response in Saccharomyces cerevisiae clinical strains. BMC Genomics 13, 419. Details PubMed
(2012) Isolation and amplification of fungal RNA for microarray analysis from host samples. In: Brand AC, MacCallum DM (eds.) Methods in Molecular Biology. Host-fungus interactions. Methods and Protocols. 845, pp. 411-421. Humana Press (Springer). Details PubMed
(2012) The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor. PLOS Pathog 8(3), e1002592. Details PubMed
(2012) Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLOS One 7(6), e38584. Details PubMed
(2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLOS One 7(12), e52850-e52850. Details PubMed
(2012) Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. PLOS One 7(11), e46020-e46020. Details PubMed
(2012) Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLOS One 7(2), e31223-e31223. Details PubMed
(2012) An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells. Front Microbiol 3, 85. Details PubMed
(2012) Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLOS One 7(5), e36952. Details PubMed
(2012) Zinc exploitation by pathogenic fungi. PLOS Pathog 8(12), e1003034. (Review) Details PubMed
(2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed
(2011) Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLOS One 6(5), e19741-e19741. Details PubMed
(2011) Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol 48(15-16), 2135-2143. Details PubMed
(2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed
(2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLOS One 6(4), e18394. Details PubMed
(2011) Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol 301(5), 417-422. (Review) Details PubMed
(2011) Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases. Environ Microbiol 13(6), 1534-1548. Details PubMed
(2011) Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect 13(12-13), 963-976. (Review) Details PubMed
(2011) Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell 10(1), 98-9109. Details PubMed Open Access PDF
(2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 187(6), 3072-3086. Details PubMed
(2011) From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLOS One 6(2), e17046. Details PubMed Open Access
(2011) Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother 55(9), 4436-4439. Details PubMed
(2011) Gene expression during the distinct stages of Candidiasis. In: Calderone RA, Clancy CJ (eds.) Candida and Candidiasis. 2. Ed.. pp. 283-298. ASM Press. Details
(2010) Candida glabrata tryptophan-based pigment production via the Ehrlich pathway. Mol Microbiol 76(1), 25-47. Details PubMed
(2010) Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway. Infect Immun 78(1), 393-399. Details PubMed
(2010) Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol 12(2), 248-271. Details PubMed
(2010) Game theoretical modelling of survival strategies of Candida albicans inside macrophages. J Theor Biol 264(2), 312-318. Details PubMed
(2010) Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy. Infect Immun 78(3), 1066-1077. Details PubMed
(2010) Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence. Infect Immun 78(7), 2995-3006. Details PubMed
(2010) Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol 4, 148. Details PubMed
(2010) Chapter 5: Secreted Candida proteins: Pathogenicity and host immunity. In: Ashbee R, Bignell EM (eds.) Pathogenic Yeasts. The Yeast Handbook pp. 97-120. ??. Details
(2010) The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity. Infect Immun 78(11), 4754-4762. Details PubMed
(2010) Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape. Curr Opin Microbiol 13(4), 392-400. (Review) Details PubMed
(2010) Die Phasen des Invasionsprozesses von Candida albicans. DERM (5), 332-336. Details
(2010) Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation. Eukaryot Cell 9(2), 278-287. Details PubMed
(2009) Candida albicans iron acquisition within the host. FEMS Yeast Res 9(7), 1000-1012. Details PubMed
(2009) Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459(7247), 657-662. Details PubMed
(2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475. Details PubMed
(2009) The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun 77(12), 5216-5224. Details PubMed
(2009) Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology. Med Mycol 47(3), 248-258. Details PubMed
(2009) Chapter 9. Secreted Candida proteins: Pathogenicity and host immunity. In: Ashbee R, Bignell EM (eds.) Pathogenic Yeasts. The Yeast Handbook pp. 97-120. ??. Details
(2009) Introduction: host responses. Methods Mol Biol 470, 291-292. Details PubMed
(2009) Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res 9(5), 688-700. (Review) Details PubMed
(2008) The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLOS Pathog 4(11), e1000217. Details PubMed Open Access
(2008) Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. BMC Microbiol 8, 116-116. Details PubMed
(2008) Was Candida wild macht. Ärztliche Praxis DermatologieAllergologie 5, 42-43. (Review) Details
(2008) Report on FunNet 2007: Forschung an humanpathogenen Pilzen bündeln und koordinieren. Biospektrum 1, 102. (Review) Details PDF
(2008) Kex2 protease converts the endoplasmic reticulum alpha1,2-mannosidase of Candida albicans into a soluble cytosolic form. Microbiology 154(Pt 12), 3782-3794. Details PubMed
(2008) Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology 154(Pt 11), 3266-3280. Details PubMed
(2008) Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans. BMC Microbiol 8, 187-187. Details PubMed
(2008) Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 10(3), 807-820. Details PubMed
(2008) From attachment to invasion: infection associated genes of Candida albicans. Nihon Ishinkin Gakkai Zasshi 49(4), 245-251. Details PubMed
(2007) Introduction In: d'Enfert C, Hube B (eds.) Candida. Comparative and functional genomics. pp. 1-5. Caister Academic Press. ISBN: 9781904455134. Details
(2007) The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications. Infect Immun 75(3), 1493-1501. Details PubMed
(2007) Report on FunNet 2007: Focussing and coordinating European research on human pathogenic fungi. Mycology Newsletter 1, 23. (Review) Details
(2007) The role of secreted aspartyl proteinases in Candida albicans keratitis. Invest Ophthalmol Vis Sci 48(8), 3559-3565. Details PubMed
(2007) In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol Microbiol 63(6), 1606-1628. Details PubMed
(2007) Haemoperfused liver as an ex vivo model for organ invasion of Candida albicans. J Med Microbiol 56(Pt 2), 266-270. Details PubMed
(2007) Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest 117(12), 3664-3672. Details PubMed
(2007) In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol 9(12), 2938-2954. Details PubMed
(2006) Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem 281(2), 688-694. Details PubMed
(2006) MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur. Microbiology 152(Pt 2), 547-554. Details PubMed
(2006) Transcriptional profiling of Candida albicans in human blood. Microbe / ASM News 1, 76-80. (Review) Details
(2006) Infection-associated genes of Candida albicans. Future Microbiol 1(2), 209-218. (Review) Details PubMed
(2006) Candida and Candidosis today: where are we, and where to go? The Interdisciplinary Forum on Candidosis (IFOCAN) 2005, Göttingen (Germany), 23-25 September 2005. FEMS Yeast Res 6(8), 1290-1294. (Review) Details PubMed
(2006) Comparison of susceptibility and transcription profile of the new antifungal Hassallidin A with caspofungin. Biochem Biophys Res Commun 349(2), 740-749. Details PubMed
(2006) Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia. Nat Protoc 1(6), 2767-2773. Details PubMed
(2006) In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses 49(3), 159-168. Details PubMed
(2005) Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. J Antimicrob Chemother 55(5), 645-654. Details PubMed
(2005) CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res 33(Database issue), D353-D357. Details PubMed
(2005) Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 56(2), 397-415. Details PubMed Open Access
(2005) Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans. Microbiology 151(Pt 10), 3381-3394. Details PubMed
(2005) Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes. Curr Drug Targets 6(8), 863-874. Details PubMed
(2005) Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun 73(5), 2758-2765. Details PubMed
(2005) Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother 55(5), 663-673. Details PubMed
(2004) Transcriptional profiling of Candida albicans during infections. Mikologia Lekarska 11, 157-163. (Review) Details
(2004) From commensal to pathogen: stage- and tissue-specific gene expression of Candida albicans. Curr Opin Microbiol 7(4), 336-341. (Review) Details PubMed
(2004) Comparative genomics using Candida albicans DNA microarrays reveals absence and divergence of virulence-associated genes in Candida dubliniensis. Microbiology 150(Pt 10), 3363-3382. Details PubMed
(2004) Candida albicans proteinases and host/pathogen interactions. Cell Microbiol 6(10), 915-926. (Review) Details PubMed
(2004) Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis. Microbiology 150(Pt 9), 2807-2813. Details PubMed
(2004) Candida albicans-Infektionsmodelle. Bioforum 11, 2-3. (Review) Details
(2004) Chapter 3. Virulence factors that promote invasion of Candida albicans. In: San-Blas G, Calderone RA (eds.) Pathogenic Fungi: Host Interactions and Emerging Strategies for Control. pp. 97-127. Caister Academic Press. Details
(0) Chapter 9. Postgenomic approaches to analyse Candida albicans pathogenicity. In: Brown A (ed.) The Mycota Vol. XII, Fungal Genomics and Proteomics, pp. 163-184. Springer Verlag. Details
(0) In vitro-Modelle auf der Basis von rekonstituierter humaner Haut/Schleimhaut zur Charakterisierung der Interaktion zwischen C. albicans und Wirtszellen. Der Hautarzt 59(12), (Review) Details
(0) Untersuchungen zur Invasivität von Candida albicans. Epidemiologisches Bulletin, Robert Koch-Institut 29, 230-231. (Review) Details