Graf K, Hube B, Brunke S (2021) Experimental evolution of Candida by serial passaging in host cells. Methods Mol Biol 2260, 145-154. Details PubMed

Mogavero S, Hube B (2021) Candida albicans Interaction with oral epithelial cells: Adhesion, invasion and damage assays. Methods Mol Biol 2260, 133-143. Details PubMed

Commichau FM, Anstatt J, Krappmann S, Stegmann E, Banhart S, Papenfort K, Brunke S, Hube B, Bramkamp M, Herbert M, Sander J, Mueller JW, Wagner M, Daus ML (2020) Wettrüsten zwischen Pilz und Wirt. BIOSpektrum 26(3), 280-286. Details PubMed PDF

Correia I, Wilson D, Hube B, Pla J (2020) Characterization of a Candida albicans mutant defective in all MAPKs highlights the major role of hog1 in the MAPK signaling network. J Fungi (Basel) 6(4), E230. Details PubMed Open Access

Costa ACBP, Back-Brito GN, Mayer FL, Hube B, Wilson D (2020) Candida albicans Mrv8, is involved in epithelial damage and biofilm formation. FEMS Yeast Res 20(5), foaa033. Details PubMed Open Access PDF

d'Enfert C, Kaune AK, Alaban LR, Chakraborty S, Cole N, Delavy M, Kosmala D, Marsaux B, Fróis-Martins R, Morelli M, Rosati D, Valentine M, Xie Z, Emritloll Y, Warn PA, Bequet F, Bougnoux ME, Bornes S, Gresnigt MS, Hube B, Jacobsen ID, Legrand M, Leibundgut-Landmann S, Manichanh C, Munro CA, Netea MG, Queiroz K, Roget K, Thomas V, Thoral C, Van den Abbeele P, Walker AW, Brown AJP (2020) The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives. FEMS Microbiol Rev [Epub ahead of print] Details PubMed

Ho J, Wickramasinghe DN, Nikou SA, Hube B, Richardson JP, Naglik JR (2020) Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. Cells 9(3), 699. Details PubMed Open Access PDF

Jung P, Mischo CE, Gunaratnam G, Spengler C, Becker SL, Hube B, Jacobs K, Bischoff M (2020) Candida albicans adhesion to central venous catheters: Impact of blood plasma-driven germ tube formation and pathogen-derived adhesins. Virulence 11(1), 1453-1465. Details PubMed

Kämmer P, McNamara S*, Wolf T, Conrad T, Allert S, Gerwien F, Hünniger K, Kurzai O, Guthke R, Hube B, Linde J, Brunke S (2020) Survival strategies of pathogenic Candida species in human blood show independent and specific adaptations. mBio 11(5), e02435-20. Details PubMed

König A, Hube B, Kasper L (2020) The dual Function of the fungal toxin candidalysin during Candida albicans-macrophage interaction and virulence. Toxins 12(8), 469. Details PubMed Open Access PDF

König A, Müller R, Mogavero S, Hube B (2020) Fungal factors involved in host immune evasion, modulation and exploitation during infection. Cell Microbiol 23(1), e13272. Details PubMed Open Access PDF

Kumamoto CA, Gresnigt MS, Hube B (2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15. Details PubMed

Mirhakkak M, Schäuble S, Klassert T, Brunke S, Brandt P, Loos D, Uribe R, de Oliveira Lino FS, Ni Y, Vylkova S, Slevogt H, Hube B, Weiss G, Sommer M, Panagiotou G (2020) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J [Epub ahead of print] Details PubMed Open Access

Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, Häder A, Krüger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, Hünniger K, Kniemeyer O, Brakhage AA, Morschhäuser J, Hube B, Vylkova S, Kurzai O, Martin R (2020) Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11(2), e00206-20. Details PubMed Open Access PDF

Seelbinder B, Chen J, Brunke S, Vazquez-Uribe R, Santhanam R, Meyer AC, de Oliveira Lino FS, Chan KF, Loos D, Imamovic L, Tsang CC, Lam RP, Sridhar S, Kang K, Hube B, Woo PCY, Sommer MOA, Panagiotou G (2020) Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria. Microbiome 8(1), 133. Details PubMed Open Access PDF

Sprenger M, Brunke S, Hube B, Kasper L (2020) A TRP1-marker-based system for gene complementation, overexpression, reporter gene expression, and gene modification in Candida glabrata. FEMS Yeast Res 20(8), foaa066. Details PubMed Open Access

Sprenger M, Hartung TS, Allert S, Wisgott S, Niemiec MJ, Graf K, Jacobsen ID, Kasper L, Hube B (2020) Fungal biotin homeostasis is essential for immune evasion after macrophage phagocytosis and virulence. Cell Microbiol 22(7), e13197. Details PubMed Open Access PDF

Westman J, Walpole GFW, Kasper L, Xue BY, Elshafee O, Hube B, Grinstein S (2020) Lysosome fusion maintains phagosome integrity during fungal infection. Cell Host Microbe S1931-3128(20), 30505-9. Details PubMed

Arastehfar A, Boekhout T, Butler G, De Cesare GB, Dolk E, Gabaldón T, Hafez A, Hube B, Hagen F, Hovhannisyan H, Iracane E, Kostrzewa M, Lackner M, Lass-Flörl C, Llorens C, Mixão V, Munro C, Oliveira-Pacheco J, Pekmezovic M, Pérez-Hansen A, Sanchez AR, Sauer FM, Sparbier K, Stavrou AA, Vaneechoutte M, Vatanshenassan M (2019) Recent trends in molecular diagnostics of yeast infections: from PCR to NGS. FEMS Microbiol Rev 43(5), 517-547. Details PubMed Open Access

Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6), 1340-1355. Details PubMed Open Access PDF

Chu H, Duan Y, Lang S, Jiang L, Wang Y, Llorente C, Liu J, Mogavero S, Bosques-Padilla F, Abraldes JG, Vargas V, Tu XM, Yang L, Hou X, Hube B, Stärkel P, Schnabl B (2019) The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. J Hepatol 72(3), 391-400. Details PubMed

Correia I, Prieto D, Román E, Wilson D, Hube B, Alonso-Monge R, Pla J (2019) Cooperative role of MAPK pathways in the interaction of Candida albicans with the host Epithelium. Microorganisms 8(1), 48. Details PubMed Open Access PDF

Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS (2019) CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nat Immunol 20(5), 559-570. Details PubMed Open Access PDF

Fischer D, Gessner G, Fill TP, Barnett R, Tron K, Dornblut K, Kloss F, Stallforth P, Hube B, Heinemann SH, Hertweck C, Scherlach K, Brunke S (2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19. Details PubMed Open Access PDF

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B (2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), dmm039719. Details PubMed Open Access PDF

Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C, Henley-Smith R, Thavaraj S, Tynan CJ, Gaffen SL, Hube B, Wheeler RT, Moyes DL, Naglik JR (2019) Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nat Commun 10(1), 2297. Details PubMed Open Access PDF

Ikonomova SP, Moghaddam-Taaheri P, Wang Y, Doolin MT, Stroka KM, Hube B, Karlsson AJ (2019) Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis. Protein Sci 29(2), 480-493. Details PubMed

Ishchuk OP, Ahmad KM, Koruza K, Bojanovič K, Sprenger M, Kasper L, Brunke S, Hube B, Säll T, Hellmark T, Gullstrand B, Brion C, Freel K, Schacherer J, Regenberg B, Knecht W, Piškur J (2019) RNAi as a tool to study virulence in the pathogenic yeast Candida glabrata. Front Microbiol 10, 1679. Details PubMed Open Access PDF

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. Details PubMed

Naglik JR, Gaffen SL, Hube B (2019) Candidalysin: Discovery and function in Candida albicans infections. Curr Opin Microbiol 52, 100-109. Details PubMed Open Access PDF

Pekmezovic M, Mogavero S, Naglik JR, Hube B (2019) Host-pathogen interactions during female genital tract infections. Trends Microbiol 27(12), 982-996. (Review) Details PubMed

Siscar-Lewin S, Hube B, Brunke S (2019) Antivirulence and avirulence genes in human pathogenic fungi. Virulence 10(1), 935-947. Details PubMed Open Access PDF

Swidergall M, Khalaji M, Solis N, Moyes D, Drummond R, Hube B, Lionakis M, Murdoch C, Filler S, Naglik J (2019) Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection. J Infect Dis 220(9), 1477-1488. Details PubMed Open Access PDF

Westman J, Hube B, Fairn GD (2019) Integrity under stress: Host membrane remodelling and damage by fungal pathogens. Cell Microbiol 21(4), e13016. Details PubMed Open Access PDF

Allert S*, Förster TM*, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B; *authors contributed equally (2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3), e00915. Details PubMed Open Access

Brunke S, Hube B (2018) The needle and the damage done. Nat Microbiol 3(8), 860-861. (Review) Details PubMed

Crawford AC, Lehtovirta-Morley LE, Alamir O, Niemiec MJ, Alawfi B, Alsarraf M, Skrahina V, Costa ACBP, Anderson A, Yellagunda S, Ballou ER, Hube B, Urban CF, Wilson D (2018) Biphasic zinc compartmentalisation in a human fungal pathogen. PLOS Pathog 14(5), e1007013. Details PubMed Open Access

Gerwien F, Skrahina V, Kasper L, Hube B, Brunke S (2018) Metals in fungal virulence. FEMS Microbiol Rev 42(1), fux050. (Review) Details PubMed Open Access

Hube B, Kurzai O (2018) Candida species. In: Oxford University Press (ed.) Oxford Textbook of Medical Mycology Chapter 11, pp. 77-79. Oxford University Press. ISBN: 978019875. (Review) Details

Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B (2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun 9(1), 4260. Details PubMed Open Access

Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, Ho J, Kichik N, Gaffen SL, Hube B, Naglik JR (2018) Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence. mBio 9(1), e02178-17. Details PubMed Open Access PDF

Richardson JP, Willems HME, Moyes DL, Shoaie S, Barker KS, Tan SL, Palmer GE, Hube B, Naglik JR, Peters BM (2018) Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa. Infect Immun 86(2), e00645-17. Details PubMed Open Access PDF

Schirbel A, Shouval DS, Hebecker B, Hube B, Sturm A, Werner L (2018) Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha. Eur J Immunol 48(11), 1826-1837. Details PubMed Open Access PDF

Sprenger M, Kasper L, Hensel M, Hube B (2018) Metabolic adaptation of intracellular bacteria and fungi to macrophages. Int J Med Microbiol 308(1), 215-227. (Review) Details PubMed Open Access

Templeton SP, Rivera A, Hube B, Jacobsen ID (2018) Editorial: Immunity to human fungal pathogens: Mechanisms of host recognition, protection, pathology, and fungal interference. Front Immunol 9, 2337. Details PubMed Open Access PDF

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL (2018) IL-36 and IL-1/IL-17 drive immunity to oral candidiasis via parallel mechanisms. J Immunol 201(2), 627-634. Details PubMed Open Access PDF

Westman J, Moran G, Mogavero S, Hube B, Grinstein S (2018) Candida albicans hyphal expansion causes phagosomal membrane damage and luminal alkalinization. mBio 9(5), e01226-18. Details PubMed Open Access PDF

Gerwien F, Safyan A, Wisgott S, Brunke S, Kasper L, Hube B (2017) The fungal pathogen Candida glabrata does not depend on surface ferric reductases for iron acquisition. Front Microbiol 8, 1055. Details PubMed Open Access

Jacobsen ID, Hube B (2017) Candida albicans morphology: still in focus. Expert Rev Anti Infect Ther 15(4), 327-330. (Review) Details PubMed Open Access

Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR (2017) Fungi that infect humans. Microbiol Spectr 5(3), FUNK-0014-2016. (Review) Details PubMed

Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M (2017) Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLOS ONE 12(10), e0184438. Details PubMed Open Access

Malavia D, Lehtovirta-Morley LE, Alamir O, Weiß E, Gow NAR, Hube B, Wilson D (2017) Zinc limitation induces a hyper-adherent goliath phenotype in Candida albicans. Front Microbiol 8, 2238. Details PubMed Open Access

Naglik JR, König A, Hube B, Gaffen SL (2017) Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol 40, 104-112. (Review) Details PubMed

Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID (2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617. Details PubMed

Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J (2017) The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans. Mol Microbiol 104(6), 989-1007. Details PubMed

Skrahina V, Brock M, Hube B, Brunke S (2017) Candida albicans Hap43 domains are required under iron starvation but not excess. Front Microbiol 8, 2388. Details PubMed Open Access

Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL (2017) Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Sci Immunol 2(17), pii: eaam8834. Details PubMed

Yu Y, Hube B, Kämper J, Meyer V, Krappmann S (2017) When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi. Virulence 8(7), 1435-1444. (Review) Details PubMed Open Access

Allert S, Brunke S, Hube B (2016) In vivo transcriptional profiling of human pathogenic fungi during infection: reflecting the real life? PLOS Pathog 12(4), e1005471. (Review) Details PubMed Open Access

Böttcher B, Pöllath C, Staib P, Hube B, Brunke S (2016) Candida species rewired hyphae developmental programs for chlamydospore formation. Front Microbiol 7, 1697. Details PubMed Open Access

Brunke S, Mogavero S, Kasper L, Hube B (2016) Virulence factors in fungal pathogens of man. Curr Opin Microbiol 32, 89-95. (Review) Details PubMed Open Access

Cassone A, Vecchiarelli A, Hube B (2016) Aspartyl proteinases of eukaryotic microbial pathogens: From eating to heating. PLOS Pathog 12(12), e1005992. (Review) Details PubMed Open Access

Förster TM, Mogavero S, Dräger A, Graf K, Polke M, Jacobsen ID, Hube B (2016) Enemies and brothers in arms: Candida albicans and gram-positive bacteria. Cell Microbiol 18(12), 1709-1715. (Review) Details PubMed

Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E (2016) In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans. Virulence 7(7), 819-825. Details PubMed Open Access

Gerwien F, Safyan A, Wisgott S, Hille F, Kämmer P, Linde J, Brunke S, Kasper L, Hube B (2016) A novel hybrid iron regulation network combines features from pathogenic and non-pathogenic yeasts. mBio 7(5), e01782-16. Details PubMed Open Access

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID (2016) Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions. Sci Rep 6, 36055. Details PubMed Open Access PDF

Höfs S, Mogavero S, Hube B (2016) Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol 54(3), 149-169. (Review) Details PubMed

Jakab Á, Mogavero S, Förster TM, Pekmezovic M, Jablonowski N, Dombrádi V, Pócsi I, Hube B (2016) Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells. Microbiology 162(12), 2116-2125. Details PubMed

Khandelwal NK, Kämmer P, Förster TM, Singh A, Coste AT, Andes DR, Hube B, Sanglard D, Chauhan N, Kaur R, d'Enfert C, Mondal AK, Prasad R (2016) Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence. Biochem J 473(11), 1537-1552. Details PubMed Open Access

Krappmann S, Meyer V, Hube B, Kämper J (2016) Interdisziplinäres Forum zu Virulenzmechanismen phyto- und humanpathogener Pilze. In: Springer Spektrum (ed.) BIOspektrum IFO-Fun 2016: Interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi, Erlangen, 10/05/2016-10/07/2016, 7-2016, pp. 742.Springer-Verlag GmbH, Heidelberg. (Review) Details

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O (2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406. Details PubMed

Moyes DL*, Wilson D*, Richardson JP*, Mogavero S*, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68. Details PubMed Open Access

Naranjo-Ortíz MA, Brock M, Brunke S, Hube B, Marcet-Houben M, Gabaldón T (2016) Widespread inter- and intra-Ddmain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Front Microbiol 7, 2001. Details PubMed Open Access

Wilson D, Naglik JR, Hube B (2016) The missing link between Candida albicans hyphal morphogenesis and host cell damage. PLOS Pathog 12(10), e1005867. (Review) Details PubMed

Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ (2016) Global identification of biofilm-specific proteolysis in Candida albicans. mBio 7(5), e01514-16. Details PubMed Open Access

Böttcher B, Palige K, Jacobsen ID, Hube B, Brunke S (2015) Csr1/Zap1 maintains zinc homeostasis and influences virulence in Candida dubliniensis but is not coupled to morphogenesis. Eukaryot Cell 14(7), 661-670. Details PubMed Open Access PDF

Brunke S, Quintin J, Kasper L, Jacobsen ID, Richter ME, Hiller E, Schwarzmüller T, d'Enfert C, Kuchler K, Rupp S, Hube B, Ferrandon D (2015) Of mice, flies - and men? Comparing fungal infection models for large-scale screening efforts. Dis Model Mech (8), 473-486. Details PubMed Open Access PDF

Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, Kasper L, Hube B, Vecchiarelli A (2015) Induction of Caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect Immun 83(5), 1940-1948. Details PubMed

Hube B (2015) Virulence profile: Bernhard Hube. Virulence 6(5), 523-525. (Review) Details PubMed

Hube B, Hay R, Brasch J, Veraldi S, Schaller M (2015) Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. J Mycol Med 25(1), e44-e58. Details PubMed

Kasper L, Miramón P, Jablonowski N, Wisgott S, Wilson D, Brunke S, Hube B (2015) Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase, and morphology. J Med Microbiol 64, 714-723. Details PubMed

Kasper L, Seider K, Hube B (2015) Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence. FEMS Yeast Res 15(5), fov042. Details PubMed

Pérez-Torrado R, Llopis S, Perrone B, Gómez-Pastor R, Hube B, Querol A (2015) Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence. PLOS One 10(3), e0122382. Details PubMed Open Access PDF

Pericolini E, Gabrielli E, Amacker M, Kasper L, Roselletti E, Luciano E, Sabbatini S, Kaeser M, Moser C, Hube B, Vecchiarelli A, Cassone A (2015) Secretory aspartyl proteinases cause vaginitis and can mediate vaginitis caused by Candida albicans in mice. MBio 6(3), e00724. Details PubMed Open Access PDF

Polke M, Hube B, Jacobsen ID (2015) Candida survival strategies. Adv Appl Microbiol 91, 139-235. Details PubMed

Brunke S, Hube B (2014) Adaptive prediction as a strategy in microbial infections. PLOS Pathog 10(10), e1004356. Details PubMed Open Access

Brunke S, Seider K, Fischer D, Jacobsen ID, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d’Enfert C, Hube B (2014) One small step for a yeast - Microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation. PLOS Pathog 10(10), e1004478. Details PubMed Open Access

Brunke S, Seider K, Richter ME, Bremer-Streck S, Ramachandra S, Kiehntopf M, Brock M, Hube B (2014) Histidine degradation via an aminotransferase increases the nutritional flexibility of Candida glabrata. Eukaryot Cell 13(6), 758-765. Details PubMed

Ene IV, Brunke S, Brown AJ, Hube B (2014) Metabolism in Fungal Pathogenesis. Cold Spring Harb Perspect Med 4(12), Details PubMed

Fischer D, Hube B, Brunke S (2014) Fine-scale chromosomal changes in fungal fitness. J Curr Fungal Infect Rep Vol. 8(2), 171-178. (Review) Details

Hebecker B, Naglik JR, Hube B, Jacobsen ID (2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 12(7), 867-879. (Review) Details PubMed

Hube B (2014) Clotrimazol bei C. albicans-Infektionen. Dem Wirkmechanismus auf der Spur. Frauenarzt (4/14), 370-372. (Review) Details

Jacobsen ID, Lüttich A, Kurzai O, Hube B, Brock M (2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796. Details PubMed

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B (2014) Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLOS One 9(5), e96015. Details PubMed Open Access

Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed

Miramón P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B (2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 52(3), 223-239. Details PubMed

Quintin J, Voigt J, van der Voort R, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, van der Meer JW, Joosten LA, Kurzai O, Netea MG (2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 44(8), 2405-2414. Details PubMed

Ramachandra S, Linde J, Brock M, Guthke R, Hube B, Brunke S (2014) Regulatory networks controlling nitrogen sensing and uptake in Candida albicans. PLOS One 9(3), e92734. Details PubMed Open Access

Schwarzmüller T, Ma B, Hiller E, Istel F, Tscherner M, Brunke S, Ames L, Firon A, Green B, Cabral V, Marcet-Houben M, Jacobsen ID, Quintin J, Seider K, Frohner I, Glaser W, Jungwirth H, Bachellier-Bassi S, Chauvel M, Zeidler U, Ferrandon D, Gabaldón T, Hube B, d'Enfert C, Rupp S, Cormack B, Haynes K, Kuchler K (2014) Systematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genes. PLOS Pathog 10(6), e1004211. Details PubMed Open Access

Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, Schwarzmüller T, Barz D, Rupp S, Kuchler K, Hube B (2014) Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell 13(1), 170-183. Details PubMed

Voigt J, Hünniger K, Bouzani M, Jacobsen ID, Barz D, Hube B, Löffler J, Kurzai O (2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis 209(4), 616-626. Details PubMed

Wartenberg A, Linde J, Martin R, Schreiner M, Horn F, Jacobsen ID, Jenull S, Wolf T, Kuchler K, Guthke R, Kurzai O, Forche A, d'Enfert C, Brunke S, Hube B (2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLOS Genet 10(12), e1004824. Details PubMed Open Access

Whittington A, Gow NAR, Hube B (2014) From commensal to pathogen: Candida albicans. In: Esser K, Kurzai O (eds.) The Mycota Ed. 2. Vol. XII, pp. 3-18. Springer Verlag. Details

Wilson D, Mayer FL, Miramón P, Citiulo F, Slesiona S, Jacobsen ID, Hube B (2014) Distinct roles of Candida albicans-specific genes in host-pathogen interactions. Eukaryot Cell 13(8), 977-989. Details PubMed

Brunke S, Hube B (2013) Two unlike cousins: Candida albicans and C. glabrata infection strategies. Cell Microbiol 15(5), 701-708. (Review) Details PubMed Open Access

Hennicke F, Grumbt M, Lermann U, Ueberschaar N, Palige K, Böttcher B, Jacobsen ID, Staib C, Morschhäuser J, Monod M, Hube B, Hertweck C, Staib P (2013) Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell 12(4), 604-613. Details PubMed

Lüttich A, Brunke S, Hube B, Jacobsen ID (2013) Serial passaging of Candida albicans in systemic murine infection suggests that the wild type strain SC5314 is well adapted to the murine kidney. PLOS One 8(5), e64482. Details PubMed Open Access

Martin R, Albrecht-Eckardt D, Brunke S, Hube B, Hünniger K, Kurzai O (2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLOS One 8(3), e58613. Details PubMed Open Access

Mayer FL, Wilson D, Hube B (2013) Hsp21 potentiates antifungal drug tolerance in Candida albicans. PLOS One 8(3), e60417. Details PubMed

Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4(2), 119-128. (Review) Details PubMed

Miramón P, Kasper L, Hube B (2013) Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol 202(3), 183-195. (Review) Details PubMed

Otto GP, Ludewig K, Jacobsen ID, Schaarschmidt B, Hube B, Bauer M (2013) Limitation of (1→3)-β-D-glucan monitoring in major elective surgery involving cardiopulmonary bypass. Crit Care 17(3), 437. Details PubMed

Palige K, Linde J, Martin R, Böttcher B, Citiulo F, Sullivan DJ, Weber J, Staib C, Rupp S, Hube B, Morschhäuser J, Staib P (2013) Global transcriptome sequencing identifies chlamydospore specific markers in Candida albicans and Candida dubliniensis. PLOS One 8(4), e61940. Details PubMed

Pietrella D, Pandey N, Gabrielli E, Pericolini E, Perito S, Kasper L, Bistoni F, Cassone A, Hube B, Vecchiarelli A (2013) Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome. Eur J Immunol 43(3), 679-692. Details PubMed

Wagener J, Schneider JJ, Baxmann S, Kalbacher H, Borelli C, Nuding S, Küchler R, Wehkamp J, Kaeser MD, Mailänder-Sanchez D, Braunsdorf C, Hube B, Schild L, Forssmann WG, Korting HC, Liepke C, Schaller M (2013) A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. J Invest Dermatol 133(1), 144-153. Details PubMed

Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother 57(10), 5178-5180. Details PubMed

Cheng SC, Sprong T, Joosten LA, van der Meer JW, Kullberg BJ, Hube B, Schejbel L, Garred P, van Deuren M, Netea MG (2012) Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol 42(4), 993-991004. Details PubMed

Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel PF, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777. Details PubMed Open Access

Gow NA, Hube B (2012) Importance of the Candida albicans cell wall during commensalism and infection. Curr Opin Microbiol 15(4), 406-412. (Review) Details PubMed

Jacobsen ID, Grosse K, Hube B (2012) Embryonated chicken eggs as alternative infection model for pathogenic fungi. In: Brand AC, MacCallum DM (eds.) Methods in Molecular Biology. Host-fungus interactions. Methods and Protocols. 845, pp. 487-496. Humana Press (Springer). Details PubMed

Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B (2012) Candida albicans dimorphism as a therapeutic target. Expert Rev Anti Infect Ther 10(1), 85-93. (Review) Details PubMed

Llopis S, Querol A, Heyken A, Hube B, Jespersen L, Fernández-Espinar MT, Pérez-Torrado R (2012) Transcriptomics in human blood incubation reveals the importance of oxidative stress response in Saccharomyces cerevisiae clinical strains. BMC Genomics 13, 419. Details PubMed

Lüttich A, Brunke S, Hube B (2012) Isolation and amplification of fungal RNA for microarray analysis from host samples. In: Brand AC, MacCallum DM (eds.) Methods in Molecular Biology. Host-fungus interactions. Methods and Protocols. 845, pp. 411-421. Humana Press (Springer). Details PubMed

Mayer FL, Wilson D, Jacobsen ID, Miramón P, Große K, Hube B (2012) The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor. PLOS Pathog 8(3), e1002592. Details PubMed

Mayer FL, Wilson D, Jacobsen ID, Miramón P, Slesiona S, Bohovych IM, Brown AJ, Hube B (2012) Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLOS One 7(6), e38584. Details PubMed

Miramón P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B (2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLOS One 7(12), e52850-e52850. Details PubMed

Puri S, Kumar R, Chadha S, Tati S, Conti HR, Hube B, Cullen PJ, Edgerton M (2012) Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis. PLOS One 7(11), e46020-e46020. Details PubMed

Slesiona S, Gressler M, Mihlan M, Zaehle C, Schaller M, Barz D, Hube B, Jacobsen ID, Brock M (2012) Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLOS One 7(2), e31223-e31223. Details PubMed

Tierney L, Linde J, Müller S, Brunke S, Molina JC, Hube B, Schöck U, Guthke R, Kuchler K (2012) An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells. Front Microbiol 3, 85. Details PubMed

Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B (2012) Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PLOS One 7(5), e36952. Details PubMed

Wilson D, Citiulo F, Hube B (2012) Zinc exploitation by pathogenic fungi. PLOS Pathog 8(12), e1003034. (Review) Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Jacobsen ID, Grosse K, Berndt A, Hube B (2011) Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLOS One 6(5), e19741-e19741. Details PubMed

Losse J, Svobodová E, Heyken A, Hube B, Zipfel PF, Józsi M (2011) Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol 48(15-16), 2135-2143. Details PubMed

Luo S, Blom AM, Rupp S, Hipler UC, Hube B, Skerka C, Zipfel PF (2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed

Martin R, Moran GP, Jacobsen ID, Heyken A, Domey J, Sullivan DJ, Kurzai O, Hube B (2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLOS One 6(4), e18394. Details PubMed

Martin R, Wächtler B, Schaller M, Wilson D, Hube B (2011) Host-pathogen interactions and virulence-associated genes during Candida albicans oral infections. Int J Med Microbiol 301(5), 417-422. (Review) Details PubMed

Müller S, Fleck CB, Wilson D, Hummert C, Hube B, Brock M (2011) Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases. Environ Microbiol 13(6), 1534-1548. Details PubMed

Naglik JR, Moyes DL, Wächtler B, Hube B (2011) Candida albicans interactions with epithelial cells and mucosal immunity. Microbes Infect 13(12-13), 963-976. (Review) Details PubMed

Schild L, Heyken A, de Groot PW, Hiller E, Mock M, de Koster C, Horn U, Rupp S, Hube B (2011) Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell 10(1), 98-9109. Details PubMed Open Access PDF

Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B (2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J Immunol 187(6), 3072-3086. Details PubMed

Wächtler B, Wilson D, Haedicke K, Dalle F, Hube B (2011) From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLOS One 6(2), e17046. Details PubMed Open Access

Wächtler B, Wilson D, Hube B (2011) Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother 55(9), 4436-4439. Details PubMed

Wilson D, Mayer F, Hube B (2011) Gene expression during the distinct stages of Candidiasis. In: Calderone RA, Clancy CJ (eds.) Candida and Candidiasis. 2. Ed.. pp. 283-298. ASM Press. Details

Brunke S, Seider K, Almeida RS, Heyken A, Fleck CB, Brock M, Barz D, Rupp S, Hube B (2010) Candida glabrata tryptophan-based pigment production via the Ehrlich pathway. Mol Microbiol 76(1), 25-47. Details PubMed

Cheng SC, Chai LY, Joosten LA, Vecchiarelli A, Hube B, Van Der Meer JW, Kullberg BJ, Netea MG (2010) Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway. Infect Immun 78(1), 393-399. Details PubMed

Dalle F, Wächtler B, L'Ollivier C, Holland G, Bannert N, Wilson D, Labruère C, Bonnin A, Hube B (2010) Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol 12(2), 248-271. Details PubMed

Hummert S, Hummert C, Schröter A, Hube B, Schuster S (2010) Game theoretical modelling of survival strategies of Candida albicans inside macrophages. J Theor Biol 264(2), 312-318. Details PubMed

Jacobsen ID, Brunke S, Seider K, Schwarzmüller T, Firon A, d'Enfért C, Kuchler K, Hube B (2010) Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy. Infect Immun 78(3), 1066-1077. Details PubMed

Jacobsen ID, Grosse K, Slesiona S, Hube B, Berndt A, Brock M (2010) Embryonated eggs as an alternative infection model to investigate Aspergillus fumigatus virulence. Infect Immun 78(7), 2995-3006. Details PubMed

Linde J, Wilson D, Hube B, Guthke R (2010) Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol 4, 148. Details PubMed

Naglik JR, Hube B (2010) Chapter 5: Secreted Candida proteins: Pathogenicity and host immunity. In: Ashbee R, Bignell EM (eds.) Pathogenic Yeasts. The Yeast Handbook pp. 97-120. ??. Details

Pietrella D, Rachini A, Pandey N, Schild L, Netea M, Bistoni F, Hube B, Vecchiarelli A (2010) The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity. Infect Immun 78(11), 4754-4762. Details PubMed

Seider K, Heyken A, Lüttich A, Miramón P, Hube B (2010) Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape. Curr Opin Microbiol 13(4), 392-400. (Review) Details PubMed

Waechtler B, Hube B (2010) Die Phasen des Invasionsprozesses von Candida albicans. DERM (5), 332-336. Details

Wilson D, Hube B (2010) Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation. Eukaryot Cell 9(2), 278-287. Details PubMed

Almeida RS, Wilson D, Hube B (2009) Candida albicans iron acquisition within the host. FEMS Yeast Res 9(7), 1000-1012. Details PubMed

Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA (2009) Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459(7247), 657-662. Details PubMed

Gropp K, Schild L, Schindler S, Hube B, Zipfel PF, Skerka C (2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475. Details PubMed

Hornbach A, Heyken A, Schild L, Hube B, Löffler J, Kurzai O (2009) The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun 77(12), 5216-5224. Details PubMed

Hort W, Lang S, Brunke S, Mayser P, Hube B (2009) Analysis of differentially expressed genes associated with tryptophan-dependent pigment synthesis in M. furfur by cDNA subtraction technology. Med Mycol 47(3), 248-258. Details PubMed

Naglik JR, Hube B (2009) Chapter 9. Secreted Candida proteins: Pathogenicity and host immunity. In: Ashbee R, Bignell EM (eds.) Pathogenic Yeasts. The Yeast Handbook pp. 97-120. ??. Details

Schaller M, Weindl G, Hube B (2009) Introduction: host responses. Methods Mol Biol 470, 291-292. Details PubMed

Wilson D, Thewes S, Zakikhany K, Fradin C, Albrecht A, Almeida R, Brunke S, Grosse K, Martin R, Mayer F, Leonhardt I, Schild L, Seider K, Skibbe M, Slesiona S, Waechtler B, Jacobsen I, Hube B (2009) Identifying infection-associated genes of Candida albicans in the postgenomic era. FEMS Yeast Res 9(5), 688-700. (Review) Details PubMed

Almeida RS, Brunke S, Albrecht A, Thewes S, Laue M, Edwards JE, Filler SG, Hube B (2008) The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLOS Pathog 4(11), e1000217. Details PubMed Open Access

Bader O, Krauke Y, Hube B (2008) Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. BMC Microbiol 8, 116-116. Details PubMed

Hube B (2008) Was Candida wild macht. Ärztliche Praxis DermatologieAllergologie 5, 42-43. (Review) Details

Hube B (2008) Report on FunNet 2007: Forschung an humanpathogenen Pilzen bündeln und koordinieren. Biospektrum 1, 102. (Review) Details PDF

Mora-Montes HM, Bader O, López-Romero E, Zinker S, Ponce-Noyola P, Hube B, Gow NA, Flores-Carreón A (2008) Kex2 protease converts the endoplasmic reticulum alpha1,2-mannosidase of Candida albicans into a soluble cytosolic form. Microbiology 154(Pt 12), 3782-3794. Details PubMed

Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, Weindl G, Tappuni AR, Rodgers CA, Woodman AJ, Challacombe SJ, Schaller M, Hube B (2008) Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiology 154(Pt 11), 3266-3280. Details PubMed

Thewes S, Moran GP, Magee BB, Schaller M, Sullivan DJ, Hube B (2008) Phenotypic screening, transcriptional profiling, and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans. BMC Microbiol 8, 187-187. Details PubMed

Wozniok I, Hornbach A, Schmitt C, Frosch M, Einsele H, Hube B, Löffler J, Kurzai O (2008) Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 10(3), 807-820. Details PubMed

Zakikhany K, Thewes S, Wilson D, Martin R, Albrecht A, Hube B (2008) From attachment to invasion: infection associated genes of Candida albicans. Nihon Ishinkin Gakkai Zasshi 49(4), 245-251. Details PubMed

d'Enfert C, Hube B (2007) Introduction In: d'Enfert C, Hube B (eds.) Candida. Comparative and functional genomics. pp. 1-5. Caister Academic Press. ISBN: 9781904455134. Details

Fradin C, Mavor AL, Weindl G, Schaller M, Hanke K, Kaufmann SH, Mollenkopf H, Hube B (2007) The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications. Infect Immun 75(3), 1493-1501. Details PubMed

Hube B (2007) Report on FunNet 2007: Focussing and coordinating European research on human pathogenic fungi. Mycology Newsletter 1, 23. (Review) Details

Jackson BE, Wilhelmus KR, Hube B (2007) The role of secreted aspartyl proteinases in Candida albicans keratitis. Invest Ophthalmol Vis Sci 48(8), 3559-3565. Details PubMed

Thewes S, Kretschmar M, Park H, Schaller M, Filler SG, Hube B (2007) In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol Microbiol 63(6), 1606-1628. Details PubMed

Thewes S, Reed HK, Grosse-Siestrup C, Groneberg DA, Meissler M, Schaller M, Hube B (2007) Haemoperfused liver as an ex vivo model for organ invasion of Candida albicans. J Med Microbiol 56(Pt 2), 266-270. Details PubMed

Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M (2007) Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest 117(12), 3664-3672. Details PubMed

Zakikhany K, Naglik JR, Schmidt-Westhausen A, Holland G, Schaller M, Hube B (2007) In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cell Microbiol 9(12), 2938-2954. Details PubMed

Albrecht A, Felk A, Pichova I, Naglik JR, Schaller M, de Groot P, Maccallum D, Odds FC, Schäfer W, Klis F, Monod M, Hube B (2006) Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem 281(2), 688-694. Details PubMed

Brunke S, Hube B (2006) MfLIP1, a gene encoding an extracellular lipase of the lipid-dependent fungus Malassezia furfur. Microbiology 152(Pt 2), 547-554. Details PubMed

Fradin C, Hube B (2006) Transcriptional profiling of Candida albicans in human blood. Microbe / ASM News 1, 76-80. (Review) Details

Hube B (2006) Infection-associated genes of Candida albicans. Future Microbiol 1(2), 209-218. (Review) Details PubMed

Kaplanek P, de Boer A, Gross U, de Groot P, Hube B, Weig M (2006) Candida and Candidosis today: where are we, and where to go? The Interdisciplinary Forum on Candidosis (IFOCAN) 2005, Göttingen (Germany), 23-25 September 2005. FEMS Yeast Res 6(8), 1290-1294. (Review) Details PubMed

Neuhof T, Seibold M, Thewes S, Laue M, Han CO, Hube B, von Döhren H (2006) Comparison of susceptibility and transcription profile of the new antifungal Hassallidin A with caspofungin. Biochem Biophys Res Commun 349(2), 740-749. Details PubMed

Schaller M, Zakikhany K, Naglik JR, Weindl G, Hube B (2006) Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia. Nat Protoc 1(6), 2767-2773. Details PubMed

Sigle HC, Schäfer-Korting M, Korting HC, Hube B, Niewerth M (2006) In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. Mycoses 49(3), 159-168. Details PubMed

Copping VM, Barelle CJ, Hube B, Gow NA, Brown AJ, Odds FC (2005) Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes. J Antimicrob Chemother 55(5), 645-654. Details PubMed

d'Enfert C, Goyard S, Rodriguez-Arnaveilhe S, Frangeul L, Jones L, Tekaia F, Bader O, Albrecht A, Castillo L, Dominguez A, Ernst JF, Fradin C, Gaillardin C, Garcia-Sanchez S, de Groot P, Hube B, Klis FM, Krishnamurthy S, Kunze D, Lopez MC, Mavor A, Martin N, Moszer I, Onésime D, Perez Martin J, Sentandreu R, Valentin E, Brown AJ (2005) CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res 33(Database issue), D353-D357. Details PubMed

Fradin C, De Groot P, MacCallum D, Schaller M, Klis F, Odds FC, Hube B (2005) Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 56(2), 397-415. Details PubMed Open Access

Kunze D, Melzer I, Bennett D, Sanglard D, MacCallum D, Nörskau J, Coleman DC, Odds FC, Schäfer W, Hube B (2005) Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans. Microbiology 151(Pt 10), 3381-3394. Details PubMed

Mavor AL, Thewes S, Hube B (2005) Systemic fungal infections caused by Candida species: epidemiology, infection process and virulence attributes. Curr Drug Targets 6(8), 863-874. Details PubMed

Schaller M, Korting HC, Borelli C, Hamm G, Hube B (2005) Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Infect Immun 73(5), 2758-2765. Details PubMed

Sigle HC, Thewes S, Niewerth M, Korting HC, Schäfer-Korting M, Hube B (2005) Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother 55(5), 663-673. Details PubMed

Fradin C, Thewes S, Zakikhany K, Albrecht A, Bader O, Kunze D, Hube B (2004) Transcriptional profiling of Candida albicans during infections. Mikologia Lekarska 11, 157-163. (Review) Details

Hube B (2004) From commensal to pathogen: stage- and tissue-specific gene expression of Candida albicans. Curr Opin Microbiol 7(4), 336-341. (Review) Details PubMed

Moran G, Stokes C, Thewes S, Hube B, Coleman DC, Sullivan D (2004) Comparative genomics using Candida albicans DNA microarrays reveals absence and divergence of virulence-associated genes in Candida dubliniensis. Microbiology 150(Pt 10), 3363-3382. Details PubMed

Naglik J, Albrecht A, Bader O, Hube B (2004) Candida albicans proteinases and host/pathogen interactions. Cell Microbiol 6(10), 915-926. (Review) Details PubMed

Schaller M, Boeld U, Oberbauer S, Hamm G, Hube B, Korting HC (2004) Polymorphonuclear leukocytes (PMNs) induce protective Th1-type cytokine epithelial responses in an in vitro model of oral candidosis. Microbiology 150(Pt 9), 2807-2813. Details PubMed

Schaller M, Hube B (2004) Candida albicans-Infektionsmodelle. Bioforum 11, 2-3. (Review) Details

Schaller M, Korting HC, Hube B (2004) Chapter 3. Virulence factors that promote invasion of Candida albicans. In: San-Blas G, Calderone RA (eds.) Pathogenic Fungi: Host Interactions and Emerging Strategies for Control. pp. 97-127. Caister Academic Press. Details

Munro C, Fradin C, Bader O, Hube B (0) Chapter 9. Postgenomic approaches to analyse Candida albicans pathogenicity. In: Brown A (ed.) The Mycota Vol. XII, Fungal Genomics and Proteomics, pp. 163-184. Springer Verlag. Details

Schaller M, Zakikhany K, Weindl G, Borelli C, Korting HC, Hube B (0) In vitro-Modelle auf der Basis von rekonstituierter humaner Haut/Schleimhaut zur Charakterisierung der Interaktion zwischen C. albicans und Wirtszellen. Der Hautarzt 59(12), (Review) Details

Thewes S, Hube B (0) Untersuchungen zur Invasivität von Candida albicans. Epidemiologisches Bulletin, Robert Koch-Institut 29, 230-231. (Review) Details