(2023)
The role of host and fungal factors in the commensal-to-pathogen transition of Candida albicans.
Curr Clin Micro Rpt 10(2),
55-65.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2023)
Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging.
Aging Cell ,
e13856.
(2022)
Systemic Candidiasis in mice: New insights from an old model.
Front Fungal Biol 3,
940884.
(Review)
(2022)
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Nat Commun 13(1),
1880.
(2022)
Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection.
Front Cell Infect Microbiol 12,
866416.
(2022)
The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans.
PLOS Pathog 18(2),
e1010283.
(2021)
Aspergillus fumigatus and aspergillosis: From basics to clinics.
Stud Mycol 100,
100115.
(Review)
(2021)
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
FEMS Microbiol Rev 45(3),
fuaa060.
(Review)
(2021)
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nat Commun 12(1),
3899.
(2021)
B cell recognition of Candida albicans hyphae via TLR 2 promotes IgG1 and IL-6 secretion for TH17 differentiation.
Front Immunol 12,
698849.
