(2022)
Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection.
Front Cell Infect Microbiol 12,
866416.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2022)
The protein kinase Ire1 has a Hac1-independent essential role in iron uptake and virulence of Candida albicans.
PLOS Pathog 18(2),
e1010283.
(2021)
Aspergillus fumigatus and aspergillosis: From basics to clinics.
Stud Mycol 100,
100115.
(Review)
(2021)
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.
FEMS Microbiol Rev 45(3),
fuaa060.
(Review)
(2021)
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nat Commun 12(1),
3899.
(2021)
B cell recognition of Candida albicans hyphae via TLR 2 promotes IgG1 and IL-6 secretion for TH17 differentiation.
Front Immunol 12,
698849.
(2021)
Significant differences in host-pathogen interactions between murine and human whole blood.
Front Immunol 11,
565869.
(2021)
Functionality of the human antibody response to Candida albicans.
Virulence 12(1),
3137-3148.
(2020)
Multiplex genetic engineering exploiting pyrimidine salvage pathway-based endogenous counterselectable markers.
mBio 11(2),
e00230-20.
(2020)
Clinical Candida albicans vaginal isolates and a laboratory strain show divergent behaviors during macrophage interactions.
mSphere 5(4),
e00393-20.
