(2024)
Risk assessment with gene expression markers in sepsis development
Cell Rep Med 5,
101712.
Host-Pathogen Interactions
Sepsis is estimated to affect more than 30 million people worldwide every year with the mean hospital-wide cost per patient being above $30,000. The pathophysiology of sepsis is a complex and dynamic multifactorial process that results from the host's immune response to a pathogen and differs according to the host’s genotype, immune status, and comorbidities, as well as the type, site, and extent of infection. The impressive survival rates in surgical operations performed on the battlefield during the 19th century with a complete lack of aseptic techniques, blood transfusion, oxygen, or other paraphernalia of modern medicine also support the notion that a person’s genomic and metagenomic makeup may have a protective role in the prevention of infection or prove detrimental if a systemic infection occurs.
Our lab seeks to understand:
- the mechanisms by which the gut microbiota protects its host from gastrointestinal and lung infections
- how interactions between the microbiota, pathogens, and host drive the course of infection.
Publications
(2024)
Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκBmediated barrier protection.
PLOS Pathog 20(3),
e1012031.
(2022)
From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris.
Virulence 13(1),
191-214.
(2022)
Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.
Nat Commun 13(1),
3192.
(2022)
Molecular profiling reveals characteristic and decisive signatures in patients after allogeneic stem cell transplantation suffering from invasive pulmonary aspergillosis.
J Fungi (Basel) 8(2),
171.
(2021)
Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection.
Nat Microbiol 6(12),
1526-1536.
(2021)
Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.
PLOS One 16(11),
e0259898.
(2021)
An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness.
Gut Microbes 13(1),
1993598.
(2021)
Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels.
ISME J 15(5),
1257-1270.
(2020)
Dynamic surface proteomes of allergenic fungal conidia.
J Proteome Res 19(5),
2092-2104.
