(2022)
Composition and antifungal activity of the alkaloidal fraction of Lupinus mirabilis leaves: A biochemometrics-based exploration.
Molecules 27(9),
2832.
PhD Freddy Alexander Bernal
Transfer Group Anti-infectives +49 3641 532-1044 freddy.bernal@leibniz-hki.deCurriculum vitae
Main Research Areas
Computer-Aided Drug DiscoveryOrganic Synthesis of Drug-like Antimicrobial Compounds
Professional Career
| Since 09.2020 | Chemist for Drug Discovery, Transfer Group Anti-infectives, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI), Jena, Germany. Topic: Computer-aided discovery and optimization of novel antimicrobials. |
| 08.2015-10.2019 | Doctorate (Doctor of Natural Sciences – Pharmacy), Westfälische Wilhelms – Universität Münster, Münster, Germany. Dissertation title: Qualitative and quantitative structure-activity relationships on 2-phenyl-2,3-dihydrobenzofurans as Leishmanicidal agents. Research advisor: Prof. Dr. Thomas J. Schmidt |
| 02.2012-05.2015 | Research Assistant. Bioorganic Chemistry, Military University Nueva Granada, Cajicá, Colombia. |
| 07.2011-05.2015 | Lecturer, General Chemistry. Department of Chemistry, Military University Nueva Granada, Bogotá, Colombia. |
| 08.2011-12.2013 | Lecturer, Instrumental Analysis and Spectroscopy. Department of Educational Chemistry, Distrital University Francisco Jose de Caldas, Bogotá, Colombia. |
| 02.2010-12.2010 | Lecturer, Organic Chemistry and Analytical Chemistry. Technological Corporation of Bogota, Bogotá, Colombia. |
| 08.2007-10.2009 | Master in Sciences – Chemistry, National University of Colombia, Bogotá, Colombia. Thesis title: Isolation of secondary metabolites from the leaves of Iryanthera ulei Warb. (Myristicaceae), evaluation of their antimicrobial activity and synthesis of one 8-O-4′-neolignan. Research advisor: Prof. Dr. Luis E. Cuca. |
| 02.2002-02.2007 | Bachelor in Chemistry, National University of Colombia, Bogotá, Colombia. |
Publications
(2022)
Natural products in antibiotic development: is the success story over?
Curr Opin Biotechnol 78,
102783.
(Review)
(2022)
Development of predictive classification models for whole cell antimycobacterial activity of benzothiazinones.
J Med Chem 65(9),
6748-6763.
(2020)
(±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis.
Eur J Med Chem 205,
112493.
(2020)
Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents.
ChemMedChem 15(1),
68-78.
(2020)
Enantiomerically pure quinoline-based κ-opioid receptor agonists: Chemoenzymatic synthesis and pharmacological evaluation.
ChemMedChem 15(15),
1408-1420.
(2020)
Colombian contributions fighting leishmaniasis: A systematic review on antileishmanials combined with chemoinformatics analysis.
Molecules 25(23),
5704.
(2019)
A Comprehensive QSAR Study on Antileishmanial and Antitrypanosomal Cinnamate Ester Analogues.
Molecules 24(23),
(2018)
Insights into the interaction and binding mode of a set of antifungal azoles as inhibitors of potential fungal enzyme-based targets.
Mol Divers 22(4),
929-942.
(2016)
Application of PARAFAC and OPLS-DA analyses on HPLC fingerprints for the characterization of Hibiscus sabdariffa calyxes.
Quim. Nova 39(2),
160-166.
