- Intravital 2-photon microscopy of the immune system
- Software development for automated and advanced image analysis and model-based simulations
- Image-based Systems Biology
|since 2016||Research associate, imaging and image analysis specialist at the Hans Knoell Institute, Jena|
|2016-2016||Microscopy and imaging specialist at the Deutsches Rheuma-Forschungszentrum (DRFZ) and the Beuth Hochschule, Berlin|
|2012-2016||Microscopy and imaging specialist in the JIMI (Joint Intravital Microscopy and Imaging) project at the Deutsches Rheuma-Forschungszentrum, Max Delbrück Center (Berlin) and at the Hans Knoell Institute, Jena|
|2010-2012||Research associate and Co-manager of the Confocal and 2-Photon Microscopy Core Facility at Max Delbrück Center for Molecular Medicine in Berlin|
|2007-2010||Imaging Facility manager in the Department of Zoology at the University of Cambridge (GB)|
|1994-2007||Research associate and confocal imaging specialist in the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (USA)|
|1991-1994||Research associate in the Department of Physiology at the School of Medicine at Debrecen University (HU)|
|1985-1991||Research associate in the Department of Solid State Physics at Debrecen University (HU)|
(2020) The transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainability. Frontiers in Microbiology 11, 794.
(2020) Quantitative impact of cell membrane fluorescence labeling on phagocytosis measurements in confrontation assays. Frontiers in Microbiology 11, 1193.
(2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication 12(2), 025012.
(2020) The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Sci Rep 10(1), 7152.
(2020) Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages. Environmental Microbiology [Epub ahead of print]
(2020) Dynamic spherical harmonics approach for shape classification of migrating cells. Scientific Reports 10(1), 6072.
(2020) Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages. Microorganisms 8(4), 577.
(2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Reports 32(7), 108017.
(2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20.
(2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol 21(12), 4563-4581.
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396.
(2018) Hessian-based quantitative image analysis of host- pathogen confrontation assays. Cytometry A 93(3), 346-356.
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.
(2018) Morphology-based distinction between healthy and pathological cells utilizing fourier transforms and self-organizing maps. J Vis Exp 140, e58543.
(2018) Cell shape characterization and classification with discrete fourier transforms and self-organizing maps. Cytometry A 93(3), 323-333.
(2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370.
(2017) Disturbed canonical nuclear factor of κ light chain signaling in B cells of patients with common variable immunodeficiency. J Allergy Clin Immunol 139(1), 220-231.
(2016) Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia. Glia 64(7), 1210-1226.
(2016) Ongoing oxidative stress causes subclinicalneuronal dysfunction in the recovery phase of EAE. Front Immunol 7(92),
(2015) Automated quantification of hematopoietic cell-stromal cell interactions in histological images of undercalcified bone. JoVE 98, 52544.
(2014) Highly resolved intravital striped-illumination microscopy of germinal centers. J Vis Exp (86),
(2014) Access to follicular dendritic cells Is a pivotal step in murine chronic lymphocyticleukemia B-cell activation and proliferation. Cancer Discov 4(12), 1448-1465.
(2014) Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. Eur J Immunol 44(8), 2306-2317.
(2013) Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots. PLOS One 8(5), e64023.
(2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Dev Cell 24(6), 660-667.
(2012) High-resolution intravital microscopy. PLOS One 7(12), e50915.
(2012) Core Facility Management: A Customized Web-based Toolbox for Managing Microscopy Core Facilities. Imaging & Microscopy ,
(2010) Point scanning confocal microscopy facilitates 3D human hair follicle imaging in tissue sections. Exp Dermatol 19(7), 691-694.
(2009) Cell rearrangements, cell divisions and cell death in a migrating epithelial sheet in the abdomen of Drosophila. Development 136(14), 2403-2411.
(2009) Analysis of replication factories in human cells by super-resolution light microscopy. BMC Cell Biol 10(88),
(2007) Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials induced by M-channel inhibition. Cell Calcium 41(6), 559-571.
(2007) Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres. J Physiol 579(Pt 2), 535-551.
(2006) Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol Biol Cell 17(4), 1570-1582.
(2004) Peripheral hot spots for local Ca2+ release after single action potentials in sympathetic ganglion neurons. Biophys J 86(1 Pt 1), 163-181.
(2003) Structured light imaging: An accessible alternative to confocal imaging. Am Biotechnol Lab 21(11), 14-16.
(2001) Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. J Cell Biol 155(1), 27-39.
(2000) Origin sites of calcium release and calcium oscillations in frog sympathetic neurons. J Neurosci 20(24), 9059-9070.
(1999) Caffeine-induced [Ca2+] oscillations in neurones of frog sympathetic ganglia. J Physiol 514(Pt 1), 83-99.
(1997) Release-activated Ca2+ transport in neurons of frog sympathetic ganglia. Neuron 19(2), 403-419.
(1996) Characteristics of the ventricular transient outward potassium current in genetic rodent models of diabetes. Gen Physiol Biophys 15(3), 225-238.
(1995) Three different gating models for inactivation of the Ito in ventricular myocytes of rats and mice. Gen Physiol Biophys 14(4), 259-276.
(1995) Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. Gen Physiol Biophys 14(3), 191-201.
(1994) The study of internal friction in metal-metal layered materials. J Alloys Compd 211-212, 498-502.
(1993) Effect of H and Cu on the damping and modulus of amorphous NiZr alloys. Mater Sci Forum 119-121, 505-510.
(1990) The influence of some alloying elements on the grain boundary relaxation of alimunium In: Defect and diffusion forum 66-69, pp. 1425-1430.Trans Tech Publications Ltd.
(1987) Internal friction of Cu-Zn-Al sape memory alloys above Martensitic transformation. J. Phys. Colloques 48, C8-541-C8-546.
(1987) Stress dependent internal friction and modulus changes in iron-based metallic glasses. J. Phys. Colloques 48, C8-447-C8-450.