Anna Medyukhina
Main Research Areas
  • image analysis of host-pathogen interactions
  • image-based quantitative characterization of immune cells
  • analysis of live-cell image data
Curriculum vitae

Professional Career

since 2013 Postdoctoral researcher in the group Applied Systems Biology at Hans Knöll Institute
2014 PhD in Physical Chemistry at the Friedrich Schiller University Jena
2010 Diploma in Medical Cybernetics at Siberian State Medical University in Tomsk, Russia
Publications

Medyukhina A*, Blickensdorf M*, Cseresnyés Z, Ruef N, Stein JV, Figge MT; * authors contributed equally (2020) Dynamic spherical harmonics approach for shape classification of migrating cells. Sci Rep 10(1), 6072. Details PubMed Open Access PDF

Medyukhina A, Figge MT (2020) DeconvTest: Simulation framework for quantifying errors and selecting optimal parameters of image deconvolution. J Biophotonics 13(4), e201960079. Details PubMed Open Access PDF Supplement

Shopova IA, Belyaev I, Dasari P, Jahreis S, Stroe MC, Cseresnyés Z, Zimmermann AK, Medyukhina A, Svensson CM, Krüger T, Szeifert V, Nietzsche S, Conrad T, Blango MG, Kniemeyer O, von Lilienfeld-Toal M, Zipfel PF, Ligeti E, Figge MT, Brakhage AA (2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20. Details PubMed Open Access PDF Supplement

Sommerfeld O, Medyukhina A, Neugebauer S, Ghait M, Ulferts S, Lupp A, König R, Wetzker R, Schulz S, Figge MT, Bauer M, Press AT (2020) Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis. Molecular Therapy S1525-0016(20), 30465-2. Details PubMed

Al-Zaben N*, Medyukhina A*, Dietrich S, Marolda A, Hünniger K, Kurzai O, Figge MT; *authors contributed equally (2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9(1), 3317. Details PubMed Open Access PDF Supplement

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. Details PubMed

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amman K, Coldewey S (2018) Modeling hemolytic-uremic syndrome: In-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459. Details PubMed Open Access PDF Supplement

Dudeck J*, Medyukhina A*, Figge MT**, Dudeck A**; *authors contributed equally; **corresponding authors, authors contributed equally (2018) Waffenübergabe im Immunsystem. Laborjournal 4, 40-43. (Review) Details PDF

Schaarschmidt B, Vlaic S, Medyukhina A, Neugebauer S, Nietzsche S, Gonnert FA, Rödel J, Singer M, Kiehntopf M, Figge MT, Jacobsen ID, Bauer M, Press AT (2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8(14), 3766-3780. Details PubMed Open Access PDF

Svensson CM, Medyukhina A, Belyaev I, Al-Zaben N, Figge MT (2018) Untangling cell tracks: Quantifying cell migration by time lapse image data analysis. Cytometry A 93(3), 357-370. Details PubMed Open Access PDF

Dudeck J*, Medyukhina A*, Froebel J, Svensson C-M, Kotrba J, Gerlach M, Gradtke A-C, Schröder B, Speier S, Figge MT**, Dudeck A**; *authors contributed equally; **corresponding authors, authors contributed equally (2017) Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med 214(12), 3791-3811. Details PubMed

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M (2017) Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy. J Am Soc Nephrol 28(2), 452-459. Details PubMed

Buhlmann D*, Eberhardt HU*, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C *authors contributed equally (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629. Details PubMed

Legesse FB, Medyukhina A, Heuke S, Popp J (2015) Texture analysis and classification in coherent anti-Stokes Raman scattering (CARS) microscopy images for automated detection of skin cancer. Computerized Medical Imaging and Graphics 43, 36-43. Details PubMed

Medyukhina A, Timme S, Mokhtari Z, Figge MT (2015) Image-based Systems Biology of Infection. Cytometry A 87(6), 462-470. Details PubMed

Bergner N, Medyukhina A, Geiger KD, Kirsch M, Schackert G, Krafft C, Popp J (2013) Hyperspectral unmixing of Raman micro-images for assessment of morphological and chemical parameters in non-dried brain tumor specimens. Anal Bioanal Chem 405(27), 8719-8728. Details PubMed

Medyukhina A, Meyer T, Heuke S, Vogler T, Dietzek B, Popp J (2013) Automated seeding-based nuclei segmentation in nonlinear optical microscopy. Applied optics 52(28), 6979-6994. Details

Medyukhina A, Meyer T, Schmitt M, Romeike BF, Dietzek B, Popp J (2012) Towards automated segmentation of cells and cell nuclei in nonlinear optical microscopy. J Biophotonics 5(11-12), 878-888. Details PubMed

Meyer T, Bergner N, Medyukhina A, Dietzek B, Krafft C, Romeike BF, Reichart R, Kalff R, Popp J (2012) Interpreting CARS images of tissue within the C-H-stretching region. J Biophotonics 5(10), 729-733. Details PubMed

Medyukhina A, Vogler N, Latka I, Kemper S, Böhm M, Dietzek B, Popp J (2011) Automated classification of healthy and keloidal collagen patterns based on processing of SHG images of human skin. J Biophotonics 4(9), 627-636. Details PubMed

Vogler N, Medyukhina A, Latka I, Kemper S, Böhm M, Dietzek B, and Popp J (2011) Towards multimodal nonlinear optical tomography–experimental methodology. Laser Physics Letters 8(8), 617-624. Details