Peter F. Zipfel
Main Research Areas
  • Immune escape of human pathogenic micro-organisms
  • Infection-associated function of the complement system
  • Genetic susceptibility for infections
Curriculum vitae

Professional Career

Since 2000 Professor for infection biology, Friedrich-Schiller-University Jena (FSU Jena) 
Since 2000 Head of the department infection biology, Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
1999 Nontenured professor, University Hamburg
1993 Habilitation in immunology and molecular biology, University Hamburg
1989-2000 Group head at the Bernhard-Nocht-Institute for tropical medicine Hamburg
1989 Visiting associate, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA
1985-1988 Postdoc, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA, funded by the German Academic Exchange Service (DAAD)
1984 PhD as Dr. rer. nat., University Bremen
1980-1985 Research assistant, University Bremen
1980 Diploma in biology, University Bremen

Awards · Appointments · Scientific Activities

Since 2009  Member at the editorial board of molecular immunology, frontiers in innate immunity
2009 Excellence award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie
Since 2008 Representative of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2008 EFIS lecture award of the European Federation of Immunological Societies
Since 2007 Principal investigator of the excellence graduate school Jena School for Microbial Communication (JSMC)
2007 Heinz Spitzbart award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
Since 2006 Principal investigator of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2007-2011 President of the European Complement Network
2005 – 2012 Board member of the European Complement Network
2004 Thuringian research award
Since 2002 Deputy Director of the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
Since 2000 Project leader for infection biology, L2
1999-2001 Member at the editorial board of experimental and clinical immunology, thrombosis and haemostasis, section editor molecular immunology
Member of the European Working Party on the Genetics of Complement mediated Kidney Diseases, Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Deutsche Gesellschaft für Immunologie, Gesellschaft für Genetik, Gesellschaft für Nephrologie

Zipfel PF, Wiech T, Stea ED, Skerka C (2020) CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy JASN 31(2), 241-256. Details PubMed

Dasari P, Koleci N, Shopova I, Wartenberg D, Beyersdorf N, Dietrich S, Sahagun-Ruiz A, Figge MT, Skerka C, Brakhage AA, Zipfel PF (2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10(2573), Details PubMed Open Access PDF

Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdaukas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C (2019) Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. Nat Commun 10(1), 2961. Details PubMed

Klaile E, Müller MM, Zubiría-Barrera C, Brehme S, Klassert TE, Stock M, Durotin A, Nguyen TD, Feer S, Singer BB, Zipfel PF, Rudolphi S, Jacobsen ID, Slevogt H (2019) Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Front Microbiol 10, 2703. Details PubMed Open Access

Lang SN, Germerodt S, Glock C, Skerka C, Zipfel PF, Schuster S (2019) Molecular crypsis by pathogenic fungi using human factor H. PLoS One 14(2), e0212187. Details PubMed

Person F, Rinschen MM, Brix SR, Wulf S, Noriega MLM, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz OM, Reinhard L, Hoxha E, Zipfel PF, Bräsen JH, Wiech T (2019) Bevacizumab-associated glomerular microangiopathy. Mod Pathol 32(5), 684-700. Details PubMed

Person F, Zipfel PF, Wiech T (2019) Thrombotische Mikroangiopathie: Was gibt es Neues? Der Nephrologe 14(1), 26-31. Details

Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, Zipfel PF, Wallich R, Kraiczy P (2019) Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep 9(1), 7056. Details PubMed

Schaumburg F, Witten A, Flamen A, Stoll M, Alabi AS, Kremsner PG, Löffler B, Zipfel PF, Velavan TP, Peters G (2019) Complement 5a receptor polymorphisms are associated with PVL-positive Staphylococcus aureus colonization in African Pygmies. Clin Infec Dis 68(5), 854-856. Details PubMed

Shopova IA, Belyaev I, Dasari P, Jahreis S, Stroe MC, Cseresnyés Z, Medyukhina A, Svensson CM, Krüger T, Szeifert V, Nietzsche S, Conrad T, Kniemeyer O, Lilienfeld-Toal Mv, Zipfel PF, Ligeti E, Figge MT, Brakhage AA (2019) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. Preprint published on bioRxiv. Details Open Access PDF

Smith RJH, Appel G, Blom AM, Cook HT, D’Agati V, Fakhouri F, Véronique Fremeaux-Bacchi V, Józsi M, Kavanagh D, Lambris J, Noris M, Pickering MC, Remuzzi G, Santiago Rodriguez de Córdoba S, Sethi S, Van der Vlag J, Zipfel PF, Nester CM (2019) C3 Glomerulopathy – Understanding a Rare Complement-Driven Renal Disease. Nat Rev Nephrol 15(3), 129-143. Details PubMed

Top O, Parsons J, Bohlender LL, Michelfelder S, Kopp P, Busch-Steenberg C, Hoernstein SNW, Zipfel PF, Häffner K, Reski R, Decker EL (2019) Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors. Front Plant Sc 10, 260. Details PubMed

Walter L, Sürth V, Röttgerding F, Zipfel PF, Fritz-Wolf K, Kraiczy P (2019) Elucidating the Immune Evasion Mechanisms of Borrelia mayonii, the Causative Agent of Lyme Disease Front Immunol 10, 2722. Details PubMed

Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR (2019) ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25(3), 496-506. Details PubMed

Zecher D, Banas B, Büttner-Herold M, Kirschfink M, Zipfel PF (2019) The Case: A 78-year-old woman with acute kidney injury and hemolytic anemia. Kidney Int 95(2), 473-474. Details PubMed

Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C (2019) C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases. Front Immunol 10, 1030. Details PubMed

Zipfel PF, Wiech T, Rudnick R, Afonso S, Person F, Skerka C (2019) Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol 10, 2166. Details PubMed Open Access PDF

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amman K, Coldewey S (2018) Modeling hemolytic-uremic syndrome: in-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459. Details PubMed Open Access PDF Supplement

Hummert S, Glock C, Lang SN, Hummert C, Skerka C, Zipfel PF, Germerodt S, Schuster S (2018) Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. J R Soc Interface 15(142), pii: 20170963. Details PubMed

Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C (2018) Kallikrein cleaves C3 and activates complement. J Innate Immun 10(2), 94-105. Details PubMed

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277. Details PubMed

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed

Michelfelder S, Fischer F, Wäldin A, Hörle K, Pohl M, Parsons J, Reski R, Decker EL, Zipfel PF, Skerka C, Häffner K (2018) The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential. J Am Soc Nephrol 29(4), 1141-1153. Details PubMed

Pujol-Lereis LM, Liebisch G, Schick T, Lin Y, Grassmann F, Uchida K, Zipfel PF, Fauser S, Skerka C, Weber BHF (2018) Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS One 13(8), e0200739. Details PubMed

Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G (2018) FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. J Immunol 201(12), 3497-3502. Details PubMed

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF (2018) FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. J Immunol 200(7), 2280-2290. Details PubMed

Spartà G, Gaspert A, Neuhaus TJ, Weitz M, Mohebbi N, Odermatt U, Zipfel PF, Bergmann C, Laube GF (2018) Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report on a case series. J Innate Immun 11(4), 479-490. Details PubMed

Zipfel PF, Luo S, Dasari P, Reiher N, Jacobsen I, Beyersdorf N, Klos A, Serka C (2018) Reply to Kang and Brooks: Comment on the interpretation of binding of Pra1, the fungal immune evasion protein from Candida albicans to the human C3 and on the conformational changes of C3 upon activation: Kang and Brooks Optimization of biolayer-interfero Mol Immunol 101, 638-639. Details PubMed

Bergfeld A, Dasari P, Werner S, Hughes TR, Song WC, Hortschansky P, Brakhage AA, Hünig T, Zipfel PF, Beyersdorf N (2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844. Details PubMed

Busch C, Annamalai B, Abdusalamova K, Reichhart N, Huber C, Lin Y, JAH, Zipfel PF, Skerka C, Wildner G, Diedrichs-Möhring M, Rohrer B, Strauß O (2017) Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium. Front Immunol 8, 703. Details PubMed

Goodship TH, Cook HT, Fakhouri F, Fervenza FC, Frémeaux-Bacchi V, Kavanagh D, Nester CM, Noris M, Pickering MC, Rodríguez de Córdoba S, Roumenina LT, Sethi S, Smith RJ; Conference Participants (2017) Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Kidney Int 91(3), 539-551. Details PubMed

Hackl A, Ehren R, Kirschfink M, Zipfel PF, Beck BB, Weber LT, Habbig S (2017) Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS. Pediatr Nephrol 32(6), 1081-1087. Details PubMed

Halder LD, Abdelfatah MA, Jo EA, Jacobsen ID, Westermann M, Beyersdorf N, Lorkowski S, Zipfel PF, Skerka C (2017) Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans. Front Immunol 7, 671. Details PubMed

Klaile E, Müller MM, Schäfer MR, Clauder AK, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. mBio 8(2), pii: e02142-16. Details PubMed

Michelfelder S, Parsons J, Bohlender LL, Hoernstein SN, Niederkrüger H, Busch A, Krieghoff N, Koch J, Fode B, Schaaf A, Frischmuth T, Pohl M, Zipfel PF, Reski R, Decker EL, Häffner K (2017) Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders. J Am Soc Nephrol 28(5), 1462-1474. Details PubMed

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4. Details PubMed

Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS (2017) Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction. J Innate Immun 9(1), 33-51. Details PubMed

Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, Zipfel PF, Wallich R, Kraiczy P (2017) Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep 7(1), 303. Details PubMed

Buhlmann D*, Eberhardt HU*, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C *authors contributed equally (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629. Details PubMed

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF (2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425. Details PubMed

Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K (2016) Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. PLOS ONE 11(1), e0147709. Details PubMed

Hammerschmidt H, Klevenhaus Y, Koenigs A, Hallström T, Fingerle V, Skerka C, Pos KM, Zipfel PF, Wallich R, Kraiczy P (2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Immunol 99, 407-424. Details PubMed

Koenigs A, Stahl J, Averhoff B, Göttig S, Wichelhaus TA, Wallich R, Zipfel PF, Kraiczy P (2016) CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein J Infect Dis 213(9), 1388-1399. Details PubMed

Olivar R, Luque A, Cárdenas-Brito S, Naranjo-Gómez M, Blom AM, Borràs1 F, Rodriguez de Córdoba S, Zipfel PF, Aran JM (2016) The complement inhibitor factor H generates an anti-inflammatory and tolerogenic state in monocyte-derived dendritic cells J Immunol 196(10), 4274-4290. Details PubMed

Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807. Details PubMed Open Access PDF Supplement

Rosa TF, Flammersfeld A, Ngwa CJ, Kiesow M, Fischer R, Zipfel PF, Skerka C, Pradel G (2016) The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cell Microbiol 18(4), 573-590. Details PubMed

Schäfer N, Grosche A, Reinders J, Hauck SM, Pouw RB, Kuijpers TW, Wouters D, Ehrenstein B, Enzmann V, Zipfel PF, Skerka C, Pauly D (2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Front Immunol 7, 542. Details PubMed

Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M (2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine 12, 227-238. Details PubMed

Weiss R, Rosendahl A, Czesla D, Meyer-Schwesinger C, Stahl R, Ehmke, H, Kurts C, Zipfel PF, Köhl J, Wenzel U (2016) The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension Am J Ren Physiol 310(11), F1356-F1365. Details PubMed

Bradley DT, Bourke TW, Fairley DJ, Borrow R, Shields MD, Zipfel PF, Hughes AE (2015) Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. PLOS One 10(3), e0120757. Details PubMed

Duehring S, Germerodt S, Skerka C, Zipfel PF, Dandekar T, Schuster S (2015) Host-pathogen interactions between the human innate immune system and Candida albicans - Understanding and modeling defense and evasion strategies Front Microbiol 6, 625. Details PubMed

Garrone A, Archipowa N, Zipfel PF, Hermann G, Dietzek B (2015) Plant Protochlorophyllide Oxidoreductases A and B - Catalytic Efficiency and Initial Reaction Steps. J Biol Chem 290(47), 28530-28539. Details PubMed

Genewsky A, Jost I, Busch C, Huber C, Stindl J, Skerka C, Zipfel PF, Rohrer B, Strauß O (2015) Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch 467(10), 2179-2191. Details PubMed

Hallström T, Uhde M, Singh B, Skerka C, Riesbeck K, Zipfel PF (2015) Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack. PLOS One 10(9), e0137630. Details PubMed

Kloppot P, Selle M, Kohler C, Stentzel S, Fuchs S, Liebscher V, Müller E, Kale D, Ohlsen K, Bröker BM, Zipfel PF, Kahl BC, Ehricht R, Hecker M, Engelmann S (2015) Microarray based identification of human antibodies against Staphylococcus aureus antigens. Proteomics Clin Appl 9(11-12), 1003-1011. Details PubMed

Koenigs A, Zipfel PF, Kraiczy P (2015) Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein. PLOS One 10(9), e0138398. Details PubMed

Kohler S, Hallström T, Singh B, Riesbeck K, Sparta G, Zipfel PF, Hammerschmidt S (2015) Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3. Thromb Haemost 113(1), 125-142. Details PubMed

Luo S, Hipler UC, Münzberg C, Skerka C, Zipfel PF (2015) Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical candida albicans isolates PLOS One 10(2), e0113192. Details PubMed

Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ (2015) Atypical aHUS: State of the art. Mol Immunol 67(1), 31-42. Details PubMed

Singh B, Al-Jubair T, Voraganti C, Andersson T, Mukherjee O, Su YC, Zipfel P, Riesbeck K (2015) Moraxella catarrhalis binds plasminogen to evade host innate immunity. Infect Immun 83(9), 3458-3469. Details PubMed

Zipfel PF, Skerka C (2015) Complement the alternative Pathway Encyclopedia of Life Sciences; John Wiley & Sons, Ltd, Chichester [In press] Details

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, Córdoba SR, Noris M, Pickering M, Smith R (2015) The role of complement in C3 glomerulopathy. Mol Immunol 67(1), 21-30. Details PubMed

Barthel A, Kopka I, Vogel H, Zipfel P, Heckel DG, Groot AT (2014) Immune defence strategies of generalist and specialist insect herbivores. Proc Biol Sci 281(1788), 20140897. Details PubMed

Bernhard S, Fleury C, Su YC, Zipfel PF, Koske I, Nordström T, Riesbeck K (2014) Outer Membrane Protein OlpA Contributes to Moraxella catarrhalis Serum Resistance via Interaction With Factor H and the Alternative Pathway. J Infect Dis 210(8), 1306-1310. Details PubMed

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155. Details PubMed

Fleury C, Su YC, Hallström T, Sandblad L, Zipfel PF, Riesbeck K (2014) Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance. J Immunol 192(12), 5913-5923. Details PubMed

Hammerschmidt C, Koenigs A, Siegel C, Hallström T, Skerka C, Wallich R, Zipfel PF, Kraiczy P (2014) Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes. Infect Immun 82(1), 380-392. Details PubMed

Lopez CM, Wallich R, Riesbeck K, Skerka C, Zipfel PF (2014) Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. PLOS One 9(3), e90796. Details PubMed

Mehta G, Ferreira VP, Skerka C, Zipfel PF, Banda NK (2014) New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol 62(1), 235-248. Details PubMed

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed

Noone D, Waters A, Pluthero FG, Geary DF, Kirschfink M, Zipfel PF, Licht C (2014) Successful treatment of DEAP-HUS with eculizumab. Pediatr Nephrol 29(5), 841-851. Details PubMed

Pauly D, Nagel BM, Reinders J, Killian T, Wulf M, Ackermann S, Ehrenstein B, Zipfel PF, Skerka C, Weber BH (2014) A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. PLOS One 9(5), e96371. Details PubMed

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R (2014) Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. Mol Immunol 58(1), 77-84. Details PubMed

Watson R, Lindner S, Bordereau P, Hunze EM, Tak F, Ngo S, Zipfel PF, Skerka C, Dragon-Durey MA, Marchbank KJ (2014) Standardisation of the factor H autoantibody assay. Immunobiology 219(1), 9-16. Details PubMed

Weinberger AW, Eddahabi C, Carstesen D, Zipfel PF, Walter P, Skerka C (2014) Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. Ophthalmic Res 51(2), 59-66. Details PubMed

Zipfel PF, Skerka C (2014) Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways. Int J Med Microbiol 304(2), 188-194. Details PubMed

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF (2013) Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet 22(23), 4857-4869. Details PubMed

Caesar JJ, Wallich R, Kraiczy P, Zipfel PF, Lea SM (2013) Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi. Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 6), 629-633. Details PubMed

Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C (2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617. Details PubMed

Hallström T, Siegel C, Mörgelin M, Kraiczy P, Skerka C, Zipfel PF (2013) CspA from Borrelia burgdorferi inhibits the terminal complement pathway. MBio 4(4), Details PubMed

Koenigs A, Hammerschmidt C, Jutras BL, Pogoryelov D, Barthel D, Skerka C, Kugelstadt D, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2013) BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem 288(35), 25229-25243. Details PubMed

Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC (2013) Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24(1), 53-65. Details PubMed

Luo S, Hoffmann R, Skerka C, Zipfel PF (2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. J Infect Dis 207(4), 594-603. Details PubMed

Luo S, Skerka C, Kurzai O, Zipfel PF (2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169. Details PubMed

Schwab J, Hammerschmidt C, Richter D, Skerka C, Matuschka FR, Wallich R, Zipfel PF, Kraiczy P (2013) Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. PLOS One 8(1), e53659. Details PubMed

Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G (2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13(1), 29-41. Details PubMed

Voss S, Hallström T, Saleh M, Burchhardt G, Pribyl T, Singh B, Riesbeck K, Zipfel PF, Hammerschmidt S (2013) The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin. J Biol Chem 288(22), 15614-15627. Details PubMed

Zipfel PF, Hallström T, Riesbeck K (2013) Human complement control and complement evasion by pathogenic microbes - tipping the balance. Mol Immunol 56(3), 152-160. Details PubMed

Zipfel PF, Lauer N (2013) Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches. Adv Exp Med Biol 735, 173-187. Details PubMed

Zipfel PF, Skerka C, Hallström T, Wolf G (2013) 14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013. Mol Immunol 56(3), 151-151. Details PubMed

Barthel D, Schindler S, Zipfel PF (2012) Plasminogen is a complement inhibitor. J Biol Chem 287(22), 18831-18842. Details PubMed

Barthel D, Singh B, Riesbeck K, Zipfel PF (2012) Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity. J Immunol 188(1), 379-385. Details PubMed

Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel PF, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777. Details PubMed Open Access

Foltyn Zadura A, Zipfel PF, Bokarewa MI, Sturfelt G, Jönsen A, Nilsson SC, Hillarp A, Saxne T, Trouw LA, Blom AM (2012) Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome. Arthritis Res Ther 14(4), R185. Details PubMed

Hallström T, Mörgelin M, Barthel D, Raguse M, Kunert A, Hoffmann R, Skerka C, Zipfel PF (2012) Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. J Immunol 189(10), 4939-4950. Details PubMed

Hammerschmidt C, Hallström T, Skerka C, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2012) Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol 2012, 349657. Details PubMed

Noone D, Al-Matrafi J, Tinckam K, Zipfel PF, Herzenberg AM, Thorner PS, Pluthero FG, Kahr WH, Filler G, Hebert D, Harvey E, Licht C (2012) Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab. Am J Transplant 12(9), 2546-2553. Details PubMed

Schindler MK, Schütz MS, Mühlenkamp MC, Rooijakkers SH, Hallström T, Zipfel PF, Autenrieth IB (2012) Yersinia enterocolitica YadA mediates complement evasion by recruitment and inactivation of C3 products. J Immunol 189(10), 4900-4908. Details PubMed

Benz MR, Schmid H, Heinen S, Lange-Sperandio B, Hoefele J, Sitter T, Zipfel PF, Weber LT (2011) Different factor H-related protein patterns in siblings with typical hemolytic uremic syndrome. Pediatr Nephrol 26(8), 1345-1347. Details PubMed

Bradley DT, Zipfel PF, Hughes AE (2011) Complement in age-related macular degeneration: a focus on function. Eye (Lond) 25(6), 683-693. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Büttner-Mainik A, Parsons J, Jérôme H, Hartmann A, Lamer S, Schaaf A, Schlosser A, Zipfel PF, Reski R, Decker EL (2011) Production of biologically active recombinant human factor H in Physcomitrella. Plant Biotechnol J 9(3), 373-383. Details PubMed

Chen Q, Müller D, Rudolph B, Hartmann A, Kuwertz-Bröking E, Wu K, Kirschfink M, Skerka C, Zipfel PF (2011) Combined C3b and factor B autoantibodies and MPGN type II. N Engl J Med 365(24), 2340-2342. Details PubMed

Hallström T, Nordström T, Tan TT, Manolov T, Lambris JD, Isenman DE, Zipfel PF, Blom AM, Riesbeck K (2011) Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding. J Immunol 186(5), 3120-3129. Details PubMed

Lauer N, Mihlan M, Hartmann A, Schlötzer-Schrehardt U, Keilhauer C, Scholl HP, Charbel Issa P, Holz F, Weber BH, Skerka C, Zipfel PF (2011) Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. J Immunol 187(8), 4374-4383. Details PubMed

Losse J, Svobodová E, Heyken A, Hube B, Zipfel PF, Józsi M (2011) Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol 48(15-16), 2135-2143. Details PubMed

Luo S, Blom AM, Rupp S, Hipler UC, Hube B, Skerka C, Zipfel PF (2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed

Mihlan M, Blom AM, Kupreishvili K, Lauer N, Stelzner K, Bergström F, Niessen HW, Zipfel PF (2011) Monomeric C-reactive protein modulates classic complement activation on necrotic cells. FASEB J 25(12), 4198-4210. Details PubMed

Reuter M, Zipfel PF (2011) Immunevasion des Gram-positiven Bakteriums Staphylococcus aureus und der multiresistenten Formen MRSA. Medizinisch-orthopädische Technik 131, 22-22. Details

Singh B, Jalalvand F, Mörgelin M, Zipfel PF, Blom AM, Riesbeck K (2011) Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex. Mol Microbiol 81(1), 80-98. Details PubMed

Thywißen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA (2011) Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway. Front Microbiol / Fungi and their interactions 2, 96. Details PubMed

Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ (2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478(7367), 76-81. Details PubMed

Zipfel PF, Skerka C, Kupka D, Luo S (2011) Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol 301(5), 423-430. Details PubMed

Zipfel PF, Wolf G, John U, Kentouche K, Skerka C (2011) Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura? Pediatr Nephrol 26(11), 1947-1956. Details PubMed

Behnsen J, Lessing F, Schindler S, Wartenberg D, Jacobsen ID, Thoen M, Zipfel PF, Brakhage AA (2010) Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun 78(8), 3585-3594. Details PubMed

Brakhage AA, Bruns S, Thywissen A, Zipfel PF, Behnsen J (2010) Interaction of phagocytes with filamentous fungi. Curr Opin Microbiol 13(4), 409-415. Details PubMed

Reuter M, Caswell CC, Lukomski S, Zipfel PF (2010) Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels. J Biol Chem 285(49), 38473-38485. Details PubMed

Siegel C, Hallström T, Skerka C, Eberhardt H, Uzonyi B, Beckhaus T, Karas M, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2010) Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. PLOS One 5(10), e13519. Details PubMed

Gropp K, Schild L, Schindler S, Hube B, Zipfel PF, Skerka C (2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475. Details PubMed

Franke K, Nguyen M, Härtl A, Dahse HM, Vogl G, Würzner R, Zipfel PF, Künkel W, Eck R (2006) The vesicle transport protein Vac1p is required for virulence of Candida albicans. Microbiology 152(Pt 10), 3111-3121. Details PubMed

Hellwage J, Eberle F, Babuke T, Seeberger H, Richter H, Kunert A, Härtl A, Zipfel PF, Jokiranta TS, Józsi M (2006) Two factor H-related proteins from the mouse: expression analysis and functional characterization. Immunogenetics 58(11), 883-893. Details PubMed

Günther J, Nguyen M, Härtl A, Künkel W, Zipfel PF, Eck R (2005) Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans. Microbiology 151(Pt 1), 81-89. Details PubMed

Poltermann S, Nguyen M, Günther J, Wendland J, Härtl A, Künkel W, Zipfel PF, Eck R (2005) The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence. Microbiology 151(Pt 5), 1645-1655. Details PubMed