- Immune escape of human pathogenic micro-organisms
- Infection-associated function of the complement system
- Genetic susceptibility for infections
|Since 2000||Professor for infection biology, Friedrich-Schiller-University Jena (FSU Jena)|
|Since 2000||Head of the department infection biology, Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena|
|1999||Nontenured professor, University Hamburg|
|1993||Habilitation in immunology and molecular biology, University Hamburg|
|1989-2000||Group head at the Bernhard-Nocht-Institute for tropical medicine Hamburg|
|1989||Visiting associate, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA|
|1985-1988||Postdoc, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA, funded by the German Academic Exchange Service (DAAD)|
|1984||PhD as Dr. rer. nat., University Bremen|
|1980-1985||Research assistant, University Bremen|
|1980||Diploma in biology, University Bremen|
Awards · Appointments · Scientific Activities
|Since 2009||Member at the editorial board of molecular immunology, frontiers in innate immunity|
|2009||Excellence award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie|
|Since 2008||Representative of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)|
|2008||EFIS lecture award of the European Federation of Immunological Societies|
|Since 2007||Principal investigator of the excellence graduate school Jena School for Microbial Communication (JSMC)|
|2007||Heinz Spitzbart award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)|
|Since 2006||Principal investigator of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)|
|2007-2011||President of the European Complement Network|
|2005 – 2012||Board member of the European Complement Network|
|2004||Thuringian research award|
|Since 2002||Deputy Director of the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena|
|Since 2000||Project leader for infection biology, L2|
|1999-2001||Member at the editorial board of experimental and clinical immunology, thrombosis and haemostasis, section editor molecular immunology
Member of the European Working Party on the Genetics of Complement mediated Kidney Diseases, Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Deutsche Gesellschaft für Immunologie, Gesellschaft für Genetik, Gesellschaft für Nephrologie
(2020) CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy JASN 31(2), 241-256.
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10(2573),
(2019) Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. Nat Commun 10(1), 2961.
(2019) Unaltered Fungal Burden and Lethality in Human CEACAM1-Transgenic Mice During Candida albicans Dissemination and Systemic Infection. Front Microbiol 10, 2703.
(2019) Molecular crypsis by pathogenic fungi using human factor H. PLoS One 14(2), e0212187.
(2019) Bevacizumab-associated glomerular microangiopathy. Mod Pathol 32(5), 684-700.
(2019) Thrombotische Mikroangiopathie: Was gibt es Neues? Der Nephrologe 14(1), 26-31.
(2019) Author Correction: Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep 9(1), 7056.
(2019) Complement 5a receptor polymorphisms are associated with PVL-positive Staphylococcus aureus colonization in African Pygmies. Clin Infec Dis 68(5), 854-856.
(2019) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. Preprint published on bioRxiv.
(2019) C3 Glomerulopathy – Understanding a Rare Complement-Driven Renal Disease. Nat Rev Nephrol 15(3), 129-143.
(2019) Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors. Front Plant Sc 10, 260.
(2019) Elucidating the Immune Evasion Mechanisms of Borrelia mayonii, the Causative Agent of Lyme Disease Front Immunol 10, 2722.
(2019) ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25(3), 496-506.
(2019) The Case: A 78-year-old woman with acute kidney injury and hemolytic anemia. Kidney Int 95(2), 473-474.
(2019) C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases. Front Immunol 10, 1030.
(2019) Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol 10, 2166.
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.
(2018) Modeling hemolytic-uremic syndrome: in-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459.
(2018) Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. J R Soc Interface 15(142), pii: 20170963.
(2018) Kallikrein cleaves C3 and activates complement. J Innate Immun 10(2), 94-105.
(2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277.
(2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370.
(2018) The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential. J Am Soc Nephrol 29(4), 1141-1153.
(2018) Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS One 13(8), e0200739.
(2018) FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. J Immunol 201(12), 3497-3502.
(2018) FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. J Immunol 200(7), 2280-2290.
(2018) Membranoproliferative glomerulonephritis and C3 glomerulopathy in children: change in treatment modality? A report on a case series. J Innate Immun 11(4), 479-490.
(2018) Reply to Kang and Brooks: Comment on the interpretation of binding of Pra1, the fungal immune evasion protein from Candida albicans to the human C3 and on the conformational changes of C3 upon activation: Kang and Brooks Optimization of biolayer-interfero Mol Immunol 101, 638-639.
(2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844.
(2017) Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium. Front Immunol 8, 703.
(2017) Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Kidney Int 91(3), 539-551.
(2017) Successful discontinuation of eculizumab under immunosuppressive therapy in DEAP-HUS. Pediatr Nephrol 32(6), 1081-1087.
(2017) Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans. Front Immunol 7, 671.
(2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. mBio 8(2), pii: e02142-16.
(2017) Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders. J Am Soc Nephrol 28(5), 1462-1474.
(2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4.
(2017) Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction. J Innate Immun 9(1), 33-51.
(2017) Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep 7(1), 303.
(2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629.
(2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425.
(2016) Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. PLOS ONE 11(1), e0147709.
(2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Immunol 99, 407-424.
(2016) CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein J Infect Dis 213(9), 1388-1399.
(2016) The complement inhibitor factor H generates an anti-inflammatory and tolerogenic state in monocyte-derived dendritic cells J Immunol 196(10), 4274-4290.
(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807.
(2016) The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cell Microbiol 18(4), 573-590.
(2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Front Immunol 7, 542.
(2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine 12, 227-238.
(2016) The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension Am J Ren Physiol 310(11), F1356-F1365.
(2015) Susceptibility to invasive meningococcal disease: polymorphism of complement system genes and Neisseria meningitidis factor H binding protein. PLOS One 10(3), e0120757.
(2015) Host-pathogen interactions between the human innate immune system and Candida albicans - Understanding and modeling defense and evasion strategies Front Microbiol 6, 625.
(2015) Plant Protochlorophyllide Oxidoreductases A and B - Catalytic Efficiency and Initial Reaction Steps. J Biol Chem 290(47), 28530-28539.
(2015) Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch 467(10), 2179-2191.
(2015) Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack. PLOS One 10(9), e0137630.
(2015) Microarray based identification of human antibodies against Staphylococcus aureus antigens. Proteomics Clin Appl 9(11-12), 1003-1011.
(2015) Translation Elongation Factor Tuf of Acinetobacter baumannii Is a Plasminogen-Binding Protein. PLOS One 10(9), e0138398.
(2015) Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3. Thromb Haemost 113(1), 125-142.
(2015) Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical candida albicans isolates PLOS One 10(2), e0113192.
(2015) Atypical aHUS: State of the art. Mol Immunol 67(1), 31-42.
(2015) Moraxella catarrhalis binds plasminogen to evade host innate immunity. Infect Immun 83(9), 3458-3469.
(2015) Complement the alternative Pathway Encyclopedia of Life Sciences; John Wiley & Sons, Ltd, Chichester [In press]
(2015) The role of complement in C3 glomerulopathy. Mol Immunol 67(1), 21-30.
(2014) Immune defence strategies of generalist and specialist insect herbivores. Proc Biol Sci 281(1788), 20140897.
(2014) Outer Membrane Protein OlpA Contributes to Moraxella catarrhalis Serum Resistance via Interaction With Factor H and the Alternative Pathway. J Infect Dis 210(8), 1306-1310.
(2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155.
(2014) Identification of a Haemophilus influenzae factor H-Binding lipoprotein involved in serum resistance. J Immunol 192(12), 5913-5923.
(2014) Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes. Infect Immun 82(1), 380-392.
(2014) Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. PLOS One 9(3), e90796.
(2014) New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol 62(1), 235-248.
(2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264.
(2014) Successful treatment of DEAP-HUS with eculizumab. Pediatr Nephrol 29(5), 841-851.
(2014) A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. PLOS One 9(5), e96371.
(2014) Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. Mol Immunol 58(1), 77-84.
(2014) Standardisation of the factor H autoantibody assay. Immunobiology 219(1), 9-16.
(2014) Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. Ophthalmic Res 51(2), 59-66.
(2014) Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways. Int J Med Microbiol 304(2), 188-194.
(2013) Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet 22(23), 4857-4869.
(2013) Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi. Acta Crystallogr Sect F Struct Biol Cryst Commun 69(Pt 6), 629-633.
(2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617.
(2013) CspA from Borrelia burgdorferi inhibits the terminal complement pathway. MBio 4(4),
(2013) BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem 288(35), 25229-25243.
(2013) Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24(1), 53-65.
(2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. J Infect Dis 207(4), 594-603.
(2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169.
(2013) Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. PLOS One 8(1), e53659.
(2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13(1), 29-41.
(2013) The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin. J Biol Chem 288(22), 15614-15627.
(2013) Human complement control and complement evasion by pathogenic microbes - tipping the balance. Mol Immunol 56(3), 152-160.
(2013) Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches. Adv Exp Med Biol 735, 173-187.
(2013) 14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013. Mol Immunol 56(3), 151-151.
(2012) Plasminogen is a complement inhibitor. J Biol Chem 287(22), 18831-18842.
(2012) Haemophilus influenzae uses the surface protein E to acquire human plasminogen and to evade innate immunity. J Immunol 188(1), 379-385.
(2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLOS Pathog 8(6), e1002777.
(2012) Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome. Arthritis Res Ther 14(4), R185.
(2012) Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. J Immunol 189(10), 4939-4950.
(2012) Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol 2012, 349657.
(2012) Antibody mediated rejection associated with complement factor h-related protein 3/1 deficiency successfully treated with eculizumab. Am J Transplant 12(9), 2546-2553.
(2012) Yersinia enterocolitica YadA mediates complement evasion by recruitment and inactivation of C3 products. J Immunol 189(10), 4900-4908.
(2011) Different factor H-related protein patterns in siblings with typical hemolytic uremic syndrome. Pediatr Nephrol 26(8), 1345-1347.
(2011) Complement in age-related macular degeneration: a focus on function. Eye (Lond) 25(6), 683-693.
(2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7.
(2011) Production of biologically active recombinant human factor H in Physcomitrella. Plant Biotechnol J 9(3), 373-383.
(2011) Combined C3b and factor B autoantibodies and MPGN type II. N Engl J Med 365(24), 2340-2342.
(2011) Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding. J Immunol 186(5), 3120-3129.
(2011) Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. J Immunol 187(8), 4374-4383.
(2011) Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol 48(15-16), 2135-2143.
(2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029.
(2011) Monomeric C-reactive protein modulates classic complement activation on necrotic cells. FASEB J 25(12), 4198-4210.
(2011) Immunevasion des Gram-positiven Bakteriums Staphylococcus aureus und der multiresistenten Formen MRSA. Medizinisch-orthopädische Technik 131, 22-22.
(2011) Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex. Mol Microbiol 81(1), 80-98.
(2011) Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway. Front Microbiol / Fungi and their interactions 2, 96.
(2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478(7367), 76-81.
(2011) Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol 301(5), 423-430.
(2011) Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura? Pediatr Nephrol 26(11), 1947-1956.
(2010) Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun 78(8), 3585-3594.
(2010) Interaction of phagocytes with filamentous fungi. Curr Opin Microbiol 13(4), 409-415.
(2010) Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels. J Biol Chem 285(49), 38473-38485.
(2010) Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. PLOS One 5(10), e13519.
(2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475.
(2006) The vesicle transport protein Vac1p is required for virulence of Candida albicans. Microbiology 152(Pt 10), 3111-3121.
(2006) Two factor H-related proteins from the mouse: expression analysis and functional characterization. Immunogenetics 58(11), 883-893.
(2005) Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans. Microbiology 151(Pt 1), 81-89.
(2005) The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence. Microbiology 151(Pt 5), 1645-1655.