Prof. Dr. Oliver Kurzai
Phone: +49 3641 532-1347 Fax: +49 3641 532-2347 Email: firstname.lastname@example.org
- Infection biology of human pathogenic fungi (especially Candida albicans)
- Infection biology of Neisseria meningitidis
|Since 2017||Chair of Medical Microbiology and Mycology, Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg and head of the research group Fungal Septomics at Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena|
|2009-2016||Professor (W2) for Fungal Septomics, Friedrich-Schiller-University Jena|
|2008||Habilitation in medical microbiology, University Würzburg|
|2006||Medical specialist in microbiology, virology and infection epidemiology (Bayerische Landesärztekammer)|
|2003||Head of a working group, Institut für Hygiene und Mikrobiologie, University Würzburg|
|2001-2002||Doctor in practical training (AiP), Institut für Hygiene und Mikrobiologie, University Würzburg|
|2002||Dr. med., “summa cum laude” University Würzburg|
|2001||Staatsexamen (state examination) in human medicine, University Würzburg|
Awards · Appointments · Scientific Activities
|Since 2014||Head of the Nationales Referenzzentrums für invasive Pilzinfektionen (NRZMyk)|
|Since 2013||Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena|
|Since 2012||Scientific Manager of the consortium “InfectControl 2020 – New Antiinfection Strategies – Science • Society • Economy” within the BMBF-Programme “Zwanzig 20 – Partnership for Innovation” (Head: Prof. A. Brakhage)|
|Since 2012||Editor-in-chief, Medical Mycology Case Reports, member (ex officio) of the executive board of the International Society for Human & Animal Mycology (ISHAM)|
|Since 2011||Elected note taker at the Deutschsprachige Mykologische Gesellschaft DMykG|
|2015-2016||Speaker of the ZIK Septomics|
|2011-2013||Editor, Journal of Basic Microbiology|
|2009||Hans-Rieth-poster prize from the Deutschsprachige Mykologische Gesellschaft (DMykG)|
|2008||Award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie|
|2003||Science award from the Unterfränkische Gedenkjahrstiftung|
|2003||Dissertation award from the medical faculty of the University Würzburg|
|2002||Becton-Dickinson PhD award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie|
(2020) Detection and differentiation of bacterial and fungal infection of Neutrophils from peripheral blood using Raman Spectroscopy. Anal Chem 92(15), 10560-10568.
(2020) How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing (EUCAST). Clin Microbiol Infect S1198-743X(20), 30347-5. (Review)
(2020) Effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure. mBio [In press]
(2020) Low rate of azole resistance in cases of avian aspergillosis in Germany. Med Mycol , myaa045.
(2020) Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. mBio 11(2), e03364-19.
(2020) First case of fatal Rhizomucor miehei endocarditis in an immunocompromised patient. Diagn Microbiol Infect Dis 98(2), 115106.
(2020) Survival strategies of pathogenic Candida species in human blood show independent and specific adaptations. mBio 11(5), e02435-20.
(2020) Candida species-dependent release of IL-12 by dendritic cells induces different levels of NK cell stimulation. J Infect Dis 221(12), 2060-2071.
(2020) Candida auris: epidemiological situation, laboratory capacity and preparedness in the European Union and European Economic Area*, January 2018 to May 2019. Euro Surveill 25(12), 2000240.
(2020) Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans. mBio 11(2), e00206-20.
(2020) Case report: Beyond the blood-retina barrier: Intravitreal caspofungin for fungal endophthalmitis. Optom Vis Sci 97(7), 473-476.
(2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9(1), 3317.
(2019) Comparative genomics of serial Candida glabrata isolates and the rapid acquisition of echinocandin resistance during therapy. Antimicrob Agents Chemother 63(2), e01628-18.
(2019) How to: EUCAST recommendations on the screening procedure E.Def 10.1 for the detection of azole resistance in Aspergillus fumigatus isolates using four-well azole-containing agar plates. Clin Microbiol Infect 25(6), 681-687.
(2019) Candida auris in germany and previous exposure to foreign healthcare. Emerg Infect Dis 25(9), 1763-1765.
(2019) ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies. Mycoses 62(10), 920-927.
(2019) Sporothrix humicola (Ascomycota: Ophiostomatales) - A soil-borne fungus with pathogenic potential in the eastern quoll (Dasyurus viverrinus). Med Mycol Case Rep 25, 39-44.
(2019) Antifungal susceptibility profiles of rare ascomycetous yeasts. J Antimicrob Chemother 74(9), 2649-2656.
(2019) Das Deutsche Pilz-Keratitis-Register: Erste Ergebnisse einer multizentrischen Erhebung [The german keratomycosis registry: Initial results of a multicenter survey]. Ophthalmologe 116(10), 957-966.
(2019) Detection of fusarium species in clinical specimens by probe-based real-time PCR. J Fungi (Basel) 5(4), 105.
(2019) Multiple signaling pathways involved in human dendritic cell maturation are affected by the fungal quorum-sensing molecule farnesol. J Immunol 203(11), 2959-2969.
(2019) Invasive fungal infection. Dtsch Arztebl Int 116(16), 271-278.
(2019) Candida auris – Steckbrief eines neuen Pilzes. Deutsches Ärzteblatt Suppl. Perspektiven der Infektiologie & Immunologie 116(1), 29-30. (Review)
(2019) A revised species concept for opportunistic Mucor species reveals species-specific antifungal susceptibility profiles. Antimicrob Agents Chemother 63(8), e00653-19.
(2019) A new species concept for the clinically relevant Mucor circinelloides complex. Persoonia - Molecular Phylogeny and Evolution of Fungi 42, 67-97.
(2019) Updates on the taxonomy of mucorales with an emphasis on clinically important taxa. J Fungi (Basel) 5(4), 106.
(2019) Outbreaks of mucorales and the species involved. Mycopathologia ,
(2019) Treatment with etanercept and low monocyte concentration contribute to the risk of invasive aspergillosis in patients post allogeneic stem cell transplantation. Sci Rep 9(1), 17231.
(2018) (1,3)-β-D-glucan-based diagnosis of invasive Candida infection versus culture-based diagnosis in patients with sepsis and with an increased risk of invasive Candida infection (CandiSep): Study protocol for a randomized controlled trial. Trials 19(1), 472.
(2018) Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus. Nat Commun 9(1), 3098.
(2018) Tintelnotia destructans: Ein neuer Feind vor dem Tore [Tintelnotia destructans: new enemy at the gates]. Ophthalmologe 115(11), 948-950.
(2018) Candida species. In: Oxford University Press (ed.) Oxford Textbook of Medical Mycology Chapter 11, pp. 77-79. Oxford University Press. ISBN: 978019875. (Review)
(2018) Phagocytes as central players in the defence against invasive fungal infection. Semin Cell Dev Biol 89, 3-15. (Review)
(2018) Candida auris: Epidemiological situation, laboratory capacity and preparedness in European Union and European economic area countries, 2013 to 2017. Euro Surveill 23(13),
(2018) Tracheal, laryngeal and pulmonary mucormycosis followed by organizing pneumonia in a patient with adult onset still's disease. Med Mycol Case Rep 20, 28-32.
(2018) Validation of a simplified in vitro Transwell® model of the alveolar surface to assess host immunity induced by different morphotypes of Aspergillus fumigatus. Int J Med Microbiol 308(8), 1009-1017.
(2018) Farnesol signalling in Candida albicans - more than just communication. Crit Rev Microbiol 44(2), 230-243. (Review)
(2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560.
(2018) Diagnosis of invasive fungal diseases in haematology and oncology: 2018 update of the recommendations of the infectious diseases working party of the German society for hematology and medical oncology (AGIHO). Mycoses 61(11), 796-813.
(2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667.
(2018) Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus. mBio 9(5), e01557-18.
(2018) FunResDB-A web resource for genotypic susceptibility testing of Aspergillus fumigatus. Med Mycol 56(1), 117-120.
(2018) First insights in NK-DC cross-talk and the importance of soluble factors during infection with Aspergillus fumigatus. Front Cell Infect Microbiol 8, 288.
(2017) Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays. Medical Image Analysis 36, 172-183.
(2017) Specific and novel microRNAs are regulated as response to fungal infection in human dendritic cells. Front Microbiol 8, 270.
(2017) Isoform localization of Dectin-1 regulates the signaling quality of anti-fungal immunity. Eur J Immunol 47(5), 848-859.
(2017) Persistence within dendritic cells marks an antifungal evasion and dissemination strategy of Aspergillus terreus. Sci Rep 7(1), 10590.
(2017) CO2 sensing in fungi: at the heart of metabolic signaling. Curr Genet 63(6), 965-972.
(2017) Caspofungin infusion solutions (50 mg/100 mL): chemical stability and antifungal activity against Candida spp. Pharmazie 72(4), 197-199.
(2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16.
(2017) Fusarium Keratitis in Germany. J Clin Microbiol 55(10), 2983-2995.
(2017) CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells. Sci Rep 7(1), 6138.
(2016) Human Invariant Natural Killer T cells possess immune-modulating functions during Aspergillus infection. Med Mycol 54(2), 169-176.
(2016) C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function. Mediators Inflamm 2016, 6129437.
(2016) Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1. Cellular Microbiology 18(7), 889-904.
(2016) Krüppel-like Factor 4 modulates interleukin-6 release in human dendritic cells after in vitro stimulation with Aspergillus fumigatus and Candida albicans Sci Rep 6, 27990.
(2016) Hypoxia attenuates anti-Aspergillus fumigatus immune responses initiated by human dendritic cells. Mycoses 59(8), 503-508.
(2016) Candida albicans induces metabolic reprogramming in human NK cells and responds to perforin with a Zinc depletion response. Front Microbiol 7, 750.
(2016) Colonization of CF patients' upper airways with S. aureus contributes more decisively to upper airway inflammation than P. aeruginosa. Med Microbiol Immunol 205(5), 485-500.
(2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597), 64-68.
(2016) Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality. EBioMedicine 12, 239-246.
(2016) Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine 12, 227-238.
(2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Medical Image Analysis 20(1), 34-51.
(2015) Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study. Front Microbiol 6, 171.
(2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276.
(2015) Host response to Candida albicans bloodstream infection and sepsis. Virulence , 1-11. (Review)
(2015) Human neutrophils dump Candida glabrata after intracellular killing. Fungal Genetics and Biology 84, 37-40.
(2015) Hypoxia-inducible factor 1α modulates metabolic activity and cytokine release in anti-Aspergillus fumigatus immune responses initiated by human dendritic cells. Int J Med Microbiol ,
(2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210.
(2015) Candida albicans bloodstream isolates in a German university hospital are genetically heterogenous and susceptible to commonly used antifungals. Int J Med Microbiol 305(7), 742-747.
(2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally.
(2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio 6(2), e00143.
(2015) Defining the transcriptomic landscape of Candida glabrata by RNA-Seq. Nucleic Acids Res 43(3), 1392-1406.
(2014) Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 370(5), 421-432.
(2014) PTX3 deficiency and aspergillosis. N Engl J Med 370(17), 1666-1667.
(2014) Neutrophil Responses to Aspergillosis: New Roles for Old Players. Mycopathologia [Epub ahead of print]
(2014) Aspergillus fumigatus induces microRNA-132 in human monocytes and dendritic cells. Int J Med Microbiol 304(5-6), 592-596.
(2014) Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care 18(5), 543.
(2014) Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers--evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases. J Immunol Methods 404, 41-51.
(2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally.
(2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796.
(2014) Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus. Int J Med Microbiol [Epub ahead of print]
(2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 52(3), 223-239.
(2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 44(8), 2405-2414.
(2014) Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis 209(4), 616-626.
(2014) Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant. PLOS Genet 10(12), e1004824.
(2013) Carbonic anhydrase regulation and CO(2) sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog. Bioorg Med Chem 21(6), 1549-1554.
(2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169.
(2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLOS One 8(3), e58613.
(2012) Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLOS One 7(12), e52850-e52850.
(2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLOS One 6(4), e18394.
(2011) Real-time PCR and quantitative culture for monitoring of experimental Aspergillus fumigatus intracranial infection in neutropenic mice. J Med Microbiol 60(Pt 7), 913-919.
(2011) The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. PLOS One 6(1), e16016-e16016.
(2011) Neisseria meningitidis adhesin NadA targets beta1 integrins: functional similarity to Yersinia invasin. J Biol Chem 286(23), 20536-20546.
(2011) Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis. Int J Med Microbiol 301(4), 325-333.
(2011) Pathogen-specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients. J Clin Microbiol 49(4), 1267-1273.
(2009) The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils. Infect Immun 77(12), 5216-5224.
(2008) Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 10(3), 807-820.
(2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12), 2290-2302.