Olaf Kniemeyer

Dr. Olaf Kniemeyer

Molecular and Applied Microbiology · Deputy head of Department +49 3641 532-1071 olaf.kniemeyer@leibniz-hki.de

Topics

A. fumigatus pathobiology and novel therapeutic strategies

Publications

Lessing F, Kniemeyer O, Wozniok I, Loeffler J, Kurzai O, Haertl A, Brakhage AA (2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12), 2290-2302.

PubMed

Kniemeyer O, Lessing F, Scheibner O, Hertweck C, Brakhage AA (2006) Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet 49(3), 178-189.

PubMed

Publication list as PDF

News

How fungi strengthen their defenses - and how we could break through them An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic. This has been discovered by a Germa… 01/13/2025 Read more

Group photo of the winners of the medac Research Award 2024, each of them holding a small bouquet of orange flowers in their hands.

medac Research Award 2024 presented for pioneering research work at the Leibniz-HKI At the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) the medac Research Award 2024 has … 12/11/2024 Read more

Scanning electron micrograph of a spore carrier of the fungus A. fumigatus. To be seen are numerous spherical spores, known as conidia.

Fungal infection: A protein weakens the immune system The mold Aspergillus fumigatus produces an enzyme on the surface of its spores with which it can attenuate the human immune response. This makes it ea… 09/04/2024 Read more

The folded structure of the precursor protein Ece1. The peptide sequence P3, shown in green in the model, shows the toxin Candidalysin of the yeast Candida albicans.

The laborious path of a fungal toxin The toxin Candidalysin of the yeast Candida albicans is incorporated into an unusual protein structure during an infection, the composition of which h… 03/12/2024 Read more

medac Managing Director Heiner Will congratulates prizewinner Anan Ibrahim

medac research award 2023 for cutting-edge research The Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) has awarded the medac research award to the institute's bes… 03/07/2024 Read more

Fluorescence microscopy of Aspergillus nidulans

Bacterial signallers in the soil Bacteria of the genus Streptomyces produce chemical substances called arginoketides, to which many other microorganisms react: Bacteria form biofilms,… 06/27/2023 Read more

Large irregular structures and small spherical structures in bright colours on a black background

Fungal spores hijack lung cells The pathogenic fungus Aspergillus fumigatus escapes elimination from surface cells of the human lung by binding to a human protein. In doing so, it is… 03/09/2023 Read more

A woman in a lab coat stands in a laboratory holding up two bottles of yellowish liquid.

How does multicellularity develop? The unicellular marine organism Salpingoeca rosetta belongs to the group of choanoflagellates. When hunting for bacteria, these protozoa can detect th… 09/02/2022 Read more

Focus on life-threatening fungal infections Collaborative Research Center "FungiNet" granted DFG funding for a further four years. 05/25/2021 Read more