Prof. Dr. Christina Zielinski

Infection Immunology · Head +49 3641 532-1251 christina.zielinski@leibniz-hki.de

Curriculum vitae

Main Research Areas

Regulation of human T cells in physiological and pathological contexts
Communication of human T cells with the tissue microenvironment
Identification of pharmacological targets for T cell-based immunotherapies in chronic infections

Professional Career

since 2021	W3-Professorship (Chair of Department of Infection Immunology) at the Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), University of Jena
2015 - 2020	Professorship of the German Center for Infection Research (DZIF) at the Technical University of Munich
2011 – 2015	Clinical training in dermatology and allergology at the Charité–Universitätsmedizin Berlin (Department of Dermatology) and Clinical Scientist Track Program of the Berlin-Brandenburg School for Regenerative Therapies, Board certification 2015
2008 – 2011	Postdoctoral training (DFG fellowship) at the Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland (Supervisor: Federica Sallusto, PhD)
2006 – 2008	Clinical training in dermatology at the University of Tübingen (Head of department: Prof. Dr. med. M. Röcken)
2007	Doctor of Medicine (summa cum laude): “Intrinsic T cell defects in a mouse model of systemic lupus erythematosus“
2006	Approbation (license to practice medicine)
1999 – 2006	Medical School at the University of Heidelberg (1 Semester Harvard Medical School, 1 Semester Duke Medical School), Scholar of the German National Academic Foundation (Studienstiftung des deutschen Volkes)

Awards · Appointments · Scientific Activities

2020	Paul Langerhans Preis der Arbeitsgemeinschaft Dermatologische Forschung
2019	Ingrid zu-Solms Preis für Medizin
2019	Deutscher Neurodermitis Preis der Deutschen Dermatologischen Gesellschaft
2015	Vortragspreis auf dem International Congress on Autoinflammation, Dresden
2014	Forschungspreis der Deutschen Gesellschaft für Rheumatologie
2014	Silver Award der LEO Pharma Research Foundation für außerordentliche Beiträge zur Dermatologischen Forschung (European Society for Dermatological Research, ESDR)
2014	Wolfgang-Schulze Preis (Deutsche Rheuma-Liga)
2013	Oscar-Gans-Förderpreis (wichtigster Preis für dermatologische Forschung in Deutschland)
2013	Paul Janssen-Preis für Dermatologie und Immunologie der Deutschen Dermatologischen Gesellschaft
2013	Forschungspreis der Berliner Gesellschaft für Dermatologie
2012	Robert-Koch-Postdoktorandenpreis für Immunologie
2012	Nils-Ilja-Richter-Preis der Deutschen Gesellschaft für Autoimmun-Erkrankungen
2012	Celgene Award for Innovation in Inflammation and Immunology Research into Dermatological Diseases (bester europäischer Beitrag zur Dermatologie durch Nachwuchsforscher, European Society for Dermatological Research)
2011	Vortragspreis, European Academy and Clinical Immunology Conference, Istanbul
2011	gewähltes Mitglied der ‘ESDR Academy for Future Leaders in Dermatology’
2011	Posterpreis, Schweizerische Gesellschaft für Allergologie und Immunologie, Lugano
2010	Posterpreis, Jahrestagung der Deutschen Gesellschaft für Immunologie, Leipzig
2010	Vortragspreis, World Immune Regulation Meeting, Davos

Publications

Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE (2023) Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation. Nat Immunol 24(2), 295-308.

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Zielinski CE (2023) T helper cell subsets: diversification of the field. Eur J Immunol , e2250218. (Review)

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de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE (2022) Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential. Sci Immunol 7(67), eabe2634.

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Haunhorst S, Bloch W, Javelle F, Krüger K, Baumgart S, Drube S, Lemhöfer C, Reuken P, Stallmach A, Müller M, Zielinski CE, Pletz MW, Gabriel HHW, Puta C (2022) A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients – indications for their potential involvement in the development of Long COVID? Front Immunol 13, 1070994. (Review)

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Stary G, Fabri M, Gebhardt C, Eming R, Matthias J, Vorobyev A, Effern M, Strobl J, Günther C, Zielinski C, Dudziak D, Géraud C, Raker V, Butze M, Zhao F, Wang Y, Gerloff D, Bertschi NL, Gaffal E, Buhl T (2022) Meeting Report: 47th Annual Meeting of the "Arbeitsgemeinschaft Dermatologische Forschung". Exp Dermatol 31(10), 1641-1651. (Review)

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Yin H, Karayel O, Chao YY, Seeholzer T, Hamp I, Plettenburg O, Gehring T, Zielinski C, Mann M, Krappmann D (2022) A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. Cell Mol Life Sci 79(2), 112.

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Arunkumar M, Zielinski CE (2021) T-Cell receptor repertoire analysis with computational tools-an immunologist's perspective. Cells 10(12), 3582. (Review)

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Chu CF, Sabath F, Fibi-Smetana S, Sun S, Öllinger R, Noeßner E, Chao YY, Rinke L, Winheim E, Rad R, Krug AB, Taher L, Zielinski CE (2021) Convalescent COVID-19 patients without comorbidities display similar immunophenotypes over time despite divergent disease severities. Front Immunol 12, 601080.

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Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K (2021) Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors. Mol Ther Methods Clin Dev 23, 476-489.

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