Christina Zielinski

Prof. Dr. Christina Zielinski

Infection Immunology · Head +49 3641 532-1251 christina.zielinski@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Regulation of human T cells in physiological and pathological contexts
  • Communication of human T cells with the tissue microenvironment
  • Identification of pharmacological targets for T cell-based immunotherapies in chronic infections
Professional Career
since 2021 W3-Professorship (Chair of Department of Infection Immunology) at the Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), University of Jena
2015 - 2020 Professorship of the German Center for Infection Research (DZIF) at the Technical University of Munich
2011 – 2015 Clinical training in dermatology and allergology at the Charité–Universitätsmedizin Berlin (Department of Dermatology) and Clinical Scientist Track Program of the Berlin-Brandenburg School for Regenerative Therapies, Board certification 2015
2008 – 2011 Postdoctoral training (DFG fellowship) at the Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland (Supervisor: Federica Sallusto, PhD)
2006 – 2008 Clinical training in dermatology at the University of Tübingen (Head of department: Prof. Dr. med. M. Röcken)
2007 Doctor of Medicine (summa cum laude): “Intrinsic T cell defects in a mouse model of systemic lupus erythematosus“
2006 Approbation (license to practice medicine)
1999 – 2006 Medical School at the University of Heidelberg (1 Semester Harvard Medical School, 1 Semester Duke Medical School), Scholar of the German National Academic Foundation (Studienstiftung des deutschen Volkes)
Awards · Appointments · Scientific Activities
2023 Elected Board member of the Germany Society for Immunology (DGFI)
2023 Member of the Editorial Board of the European Journal of Immunology
2023 Organizer of the German-Japanese Immunology Alliance
2020 Paul Langerhans Preis der Arbeitsgemeinschaft Dermatologische Forschung
2019 Ingrid zu-Solms Preis für Medizin
2019 Deutscher Neurodermitis Preis der Deutschen Dermatologischen Gesellschaft
2015 Vortragspreis auf dem International Congress on Autoinflammation, Dresden
2014 Forschungspreis der Deutschen Gesellschaft für Rheumatologie
2014 Silver Award der LEO Pharma Research Foundation für außerordentliche Beiträge zur Dermatologischen Forschung (European Society for Dermatological Research, ESDR)
2014 Wolfgang-Schulze Preis (Deutsche Rheuma-Liga)
2013 Oscar-Gans-Förderpreis (wichtigster Preis für dermatologische Forschung in Deutschland)
2013 Paul Janssen-Preis für Dermatologie und Immunologie der Deutschen Dermatologischen Gesellschaft
2013 Forschungspreis der Berliner Gesellschaft für Dermatologie
2012 Robert-Koch-Postdoktorandenpreis für Immunologie
2012 Nils-Ilja-Richter-Preis der Deutschen Gesellschaft für Autoimmun-Erkrankungen
2012 Celgene Award for Innovation in Inflammation and Immunology Research into Dermatological Diseases (bester europäischer Beitrag zur Dermatologie durch Nachwuchsforscher, European Society for Dermatological Research)
2011 Vortragspreis, European Academy and Clinical Immunology Conference, Istanbul
2011 gewähltes Mitglied der ‘ESDR Academy for Future Leaders in Dermatology’
2011 Posterpreis, Schweizerische Gesellschaft für Allergologie und Immunologie, Lugano
2010 Posterpreis, Jahrestagung der Deutschen Gesellschaft für Immunologie, Leipzig
2010 Vortragspreis, World Immune Regulation Meeting, Davos



Publications

Chu CF, Sabath F, Fibi-Smetana S, Sun S, Öllinger R, Noeßner E, Chao YY, Rinke L, Winheim E, Rad R, Krug AB, Taher L, Zielinski CE (2021) Convalescent COVID-19 patients without comorbidities display similar immunophenotypes over time despite divergent disease severities. Front Immunol 12, 601080.
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Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K (2021) Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors. Mol Ther Methods Clin Dev 23, 476-489.
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Zielinski CE (2021) Regulation of T cell responses by ionic salt signals. Cells 10(9), 2365. (Review)
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Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE (2020) Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. J Clin Invest 130(9), 4587-4600.
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Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis e Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A (2019) Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10), 1457-1973.
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Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE (2019) Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Sci Transl Med 11(480),
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Matthias J, Zielinski CE (2019) Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment. Eur J Immunol 49(9), 1321-1333.
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Palit S, Heuser C, de Almeida GP, Theis FJ, Zielinski CE (2019) Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology. Front Immunol 10, 1515.
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Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, Ullrich R (2017) Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis 32(1), 29-39.
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Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E (2017) TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunol 10(6), 1431-1442.
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