Prof. Dr. Christina Zielinski

Infection Immunology · Head +49 3641 532-1251 christina.zielinski@leibniz-hki.de

Curriculum vitae

Main Research Areas

Regulation of human T cells in physiological and pathological contexts
Communication of human T cells with the tissue microenvironment
Identification of pharmacological targets for T cell-based immunotherapies in chronic infections

Professional Career

since 2021	W3-Professorship (Chair of Department of Infection Immunology) at the Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute), University of Jena
2015 - 2020	Professorship of the German Center for Infection Research (DZIF) at the Technical University of Munich
2011 – 2015	Clinical training in dermatology and allergology at the Charité–Universitätsmedizin Berlin (Department of Dermatology) and Clinical Scientist Track Program of the Berlin-Brandenburg School for Regenerative Therapies, Board certification 2015
2008 – 2011	Postdoctoral training (DFG fellowship) at the Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland (Supervisor: Federica Sallusto, PhD)
2006 – 2008	Clinical training in dermatology at the University of Tübingen (Head of department: Prof. Dr. med. M. Röcken)
2007	Doctor of Medicine (summa cum laude): “Intrinsic T cell defects in a mouse model of systemic lupus erythematosus“
2006	Approbation (license to practice medicine)
1999 – 2006	Medical School at the University of Heidelberg (1 Semester Harvard Medical School, 1 Semester Duke Medical School), Scholar of the German National Academic Foundation (Studienstiftung des deutschen Volkes)

Awards · Appointments · Scientific Activities

2020	Paul Langerhans Preis der Arbeitsgemeinschaft Dermatologische Forschung
2019	Ingrid zu-Solms Preis für Medizin
2019	Deutscher Neurodermitis Preis der Deutschen Dermatologischen Gesellschaft
2015	Vortragspreis auf dem International Congress on Autoinflammation, Dresden
2014	Forschungspreis der Deutschen Gesellschaft für Rheumatologie
2014	Silver Award der LEO Pharma Research Foundation für außerordentliche Beiträge zur Dermatologischen Forschung (European Society for Dermatological Research, ESDR)
2014	Wolfgang-Schulze Preis (Deutsche Rheuma-Liga)
2013	Oscar-Gans-Förderpreis (wichtigster Preis für dermatologische Forschung in Deutschland)
2013	Paul Janssen-Preis für Dermatologie und Immunologie der Deutschen Dermatologischen Gesellschaft
2013	Forschungspreis der Berliner Gesellschaft für Dermatologie
2012	Robert-Koch-Postdoktorandenpreis für Immunologie
2012	Nils-Ilja-Richter-Preis der Deutschen Gesellschaft für Autoimmun-Erkrankungen
2012	Celgene Award for Innovation in Inflammation and Immunology Research into Dermatological Diseases (bester europäischer Beitrag zur Dermatologie durch Nachwuchsforscher, European Society for Dermatological Research)
2011	Vortragspreis, European Academy and Clinical Immunology Conference, Istanbul
2011	gewähltes Mitglied der ‘ESDR Academy for Future Leaders in Dermatology’
2011	Posterpreis, Schweizerische Gesellschaft für Allergologie und Immunologie, Lugano
2010	Posterpreis, Jahrestagung der Deutschen Gesellschaft für Immunologie, Leipzig
2010	Vortragspreis, World Immune Regulation Meeting, Davos

Publications

Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE (2020) Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. J Clin Invest 130(9), 4587-4600.

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Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis e Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A (2019) Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10), 1457-1973.

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Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE (2019) Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Sci Transl Med 11(480),

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Matthias J, Zielinski CE (2019) Shaping the diversity of Th2 cell responses in epithelial tissues and its potential for allergy treatment. Eur J Immunol 49(9), 1321-1333.

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Palit S, Heuser C, de Almeida GP, Theis FJ, Zielinski CE (2019) Meeting the Challenges of High-Dimensional Single-Cell Data Analysis in Immunology. Front Immunol 10, 1515.

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Barmeyer C, Schumann M, Meyer T, Zielinski C, Zuberbier T, Siegmund B, Schulzke JD, Daum S, Ullrich R (2017) Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome. Int J Colorectal Dis 32(1), 29-39.

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Pascual-Reguant A, Bayat Sarmadi J, Baumann C, Noster R, Cirera-Salinas D, Curato C, Pelczar P, Huber S, Zielinski CE, Löhning M, Hauser AE, Esplugues E (2017) TH17 cells express ST2 and are controlled by the alarmin IL-33 in the small intestine. Mucosal Immunol 10(6), 1431-1442.

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Poltorak MP, Zielinski CE (2017) Hierarchical governance of cytokine production by 6-sulfo LacNAc (slan) dendritic cells for the control of psoriasis pathogenesis. Exp Dermatol 26(4), 317-318.

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Zielinski CE (2017) Human T cell immune surveillance: Phenotypic, functional and migratory heterogeneity for tailored immune responses. Immunol Lett 190, 125-129.

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Noster R, de Koning HD, Maier E, Prelog M, Lainka E, Zielinski CE (2016) Dysregulation of proinflammatory versus anti-inflammatory human TH17 cell functionalities in the autoinflammatory Schnitzler syndrome. J Allergy Clin Immunol 138(4), 1161-11169.e6.

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