Strychnine as Target - Samarium Diiodide as Tool - A Personal Story
(2015) Strychnine as Target - Samarium Diiodide as Tool - A Personal Story The Chemical Record 15(5), 872-885.
Recently, we have accomplished one of the shortest formal total syntheses of strychnine (in ten steps and 14% overall yield or even shorter in eight steps and 10% overall yield). The evolution of a productive synthetic strategy, as well as the synthetic challenges tackled, are described here in detail, including examples of related transformations.
doi: 10.1002/tcr.201500024 PMID: 26223366