Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.

Garvey M, Baumann M, Wulff M, Kumar ST, Markx D, Morgado I, Knüpfer U, Horn U, Mawrin C, Fändrich M, Balbach J (2016) Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation. Amyloid 23(2), 76-85. PubMed

Abstract

The detailed structure of brain-derived Aβ amyloid fibrils is unknown. To approach this issue, we investigate the molecular architecture of Aβ(1-40) fibrils grown in either human cerebrospinal fluid solution, in chemically simple phosphate buffer in vitro or extracted from a cell culture model of Aβ amyloid plaque formation.

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doi: 10.3109/13506129.2016.1146989 PMID: 26972581