Protein evolution: when two become three.

Stallforth P, Clardy J (2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687. PubMed

Abstract

Bacterial signaling pathways provide wonderful systems for analyzing protein evolution in vivo. A systematic dissection of the phosphate-sensing machinery in proteobacteria shows that adaptive, not neutral, mutations disable deleterious crosstalk with closely related signaling systems.

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doi: 10.1016/j.cub.2012.07.055 PMID: 22974996