Protein evolution: when two become three.
(2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687.
Bacterial signaling pathways provide wonderful systems for analyzing protein evolution in vivo. A systematic dissection of the phosphate-sensing machinery in proteobacteria shows that adaptive, not neutral, mutations disable deleterious crosstalk with closely related signaling systems.
doi: 10.1016/j.cub.2012.07.055 PMID: 22974996