Targeted isolation of saalfelduracin B-D from Amycolatopsis saalfeldensis using LC-MS/MS-based molecular networking.

Um S, Seibel E, Schalk F, Balluf S, Beemelmanns C (2021) Targeted isolation of saalfelduracin B-D from Amycolatopsis saalfeldensis using LC-MS/MS-based molecular networking. J Nat Prod [Accepted] Open Access

Abstract

High-resolution tandem mass spectrometry (HR-MS2)-based metabolomic studies of Amycolatopsis saalfeldensis, isolated from the “Saalfelder Feengrotten” caves in Germany, led to the isolation of three ribosomally synthesized and post-translationally modified type II thiopeptides, saalfelduracin B–D (1–3) and the known saalfelduracin A (4). The structures of all four compounds were determined by comparative two-dimensional NMR analysis and high-resolution tandem mass spectrometry.

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doi: 10.1021/acs.jnatprod.0c01027