Prof. Dr. Axel A. Brakhage
Phone: +49 3641 532-1001 Fax: +49 3641 532-0802 Email: email@example.com
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
|since 2005||Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena|
|since 2005||Head of Department Molecular and Applied Microbiology, HKI Jena|
|since 2004||Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, FSU Jena|
|2000-2004||Professor (C4) and chair in microbiology, Leibniz University Hanover|
|1998-2001||Professor (C3) in microbiology, Technical University Darmstadt|
|1996||Habilitation in microbiology, Ludwig-Maximilians-University Munich|
|1992-1998||Research assistant (C1), Institute for Genetics and Microbiology, Ludwig-Maximilians-University Munich|
|1990-1992||Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG|
|1989-1990||Group head, Biotechnology, BASF AG, Ludwigshafen|
|1989||Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris|
|1985||Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster|
Awards · Appointments · Scientific Activities
|since 2019||Spokesperson of the Excellence Cluster "Balance of the Microverse"|
|since 2019||Member of the foundation board of the Foundation Regensburg Center for Interventional Immunology (RCI), Regensburg|
|since 2018||Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster|
|since 2017||Member of the Steering Committee DZIF/TTU|
|since 2017||Elected member of the American Academy of Microbiology|
|since 2017||Member of the scientific panel of the Robert-Koch-Stiftung (RKS), Berlin|
|since 2017||Member of the scientific panel of the MRC Medical Mycology Centre, Aberdeen, UK|
|since 2016||Member of the Clusterboard RIS3 Thüringen|
|since 2016||Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin|
|since 2016||Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“|
|since 2015||Elected member of the European Academy of Microbiology|
|since 2015||Honorary member of the DMykG|
|2014||Main Research Award of the German Society for Hygiene and Microbiology (DGHM)|
|since 2013||Spokesperson of the SFB/Transregio 124 FungiNet (DFG)|
|since 2013||Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology|
|since 2013||Board member of the research campus “InfectoGnostics” (BMBF)|
|since 2012||Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation”|
|2012-2016||Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology|
|2010-2012||Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena|
|2010-2016||Spokesperson (and authorised commissioner) of the Leibniz Research Cluster “Biotechnologie 2020+“|
|since 2010||Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig|
|2010-2018||Member of the scientific panel of the –Institute for Pharmaceutical Research (HIPS), Saarbrücken|
|since 2010||Member of the scientific panel of the Research Centre Borstel, Borstel|
|2010-2017||Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle|
|2009-2017||Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig|
|2009-2016||Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg|
|2009-2011||President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie|
|since 2008||Member of the university council (reappointment 2011+2015) at the Friedrich-Schiller-University Jena|
|2008-2016||Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology|
|2008||Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina|
|2007-2016||Liaison Officer for scientific misconduct at the FSU Jena|
|since 2007||Spokesperson of the excellence graduated school „Jena School for Microbial Communication”|
|2006-2008||Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“|
|2006||Heinz-Seeliger award for infection biology|
|since 2005||Scientific panel "Goettinger Center for Molecular Bio/Sciences (GZMB)", Georg-August-University Göttingen|
|since 2005||Member of the Faculty Council of the Biological Pharmaceutical Faculty, FSU Jena|
|2004-2010||Representative of the DFG priority programme 1160 "colonisation and infection through human pathogenic fungi"|
|2003-2010||Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark|
|2003-2009||Member in the programme committee of the DFG priority programme 1152 "Evolution of Metabolic Diversity"|
|2003-2004||Dean, faculty biology, Leibniz-University Hanover|
|Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg|
|since 1998||Editor of several magazines|
|since 1995||Principal investigator in EU projects|
(2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans. Cell 176(6), 1340-1355.e15.
(2019) Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism. Fungal Genet Biol 130, 98-106.
(2019) Conidial surface proteins at the interface of fungal infections. PLOS Pathogens 15(9), e1007939. (Review)
(2019) Gleichgewicht des Mikroversums. BIOspektrum 25(2), 229. (Review)
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Frontiers in Immunology 10(2537),
(2019) Fast and Quantitative Evaluation of Human Leukocyte Interaction with Aspergillus fumigatus Conidia by Flow Cytometry. Cytometry A 95(3), 332-338.
(2019) Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase. Cell Chem Biol 26(4), 524-534.
(2019) Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus. MBio 10(2), pii: e00215-19.
(2019) The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. PLoS Genetics 15(9), e1008379.
(2019) Yeast two-hybrid screening reveals a dual function for the histone acetyltransferase GcnE by controlling glutamine synthesis and development in Aspergillus fumigatus. Curr Genet 65(2), 523-538.
(2019) One step closer to precision medicine for infectious diseases. Lancet Infect Dis 19(6), 564-565. (Review)
(2019) Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus. MBio 10(3), pii: e00779-19.
(2019) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Preprint published on bioRxiv.
(2019) Redox Proteomic Analysis Reveals Oxidative Modifications of Proteins by Increased Levels of Intracellular Reactive Oxygen Species During Hypoxia Adaptation of Aspergillus fumigatus. Proteomics 19(5), e1800339.
(2019) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. Preprint published on bioRxiv.
(2019) Microbial co-cultures as source of novel drugs for infections. In: Elsevier Science (ed.) Comprehensive Natural Products III: Chemistry and Biology 3, pp. Chapter 30015. Elsevier.
(2019) Artificial Microbial Arenas: Materials for Observing and Manipulating Microbial Consortia. Adv Mater 31(24), e1900284.
(2019) High throughput gene replacement in Aspergillus fumigatus. Current Protocols in Microbiology 54(1), e88.
(2019) Towards Raman spectroscopy of urine as a screening tool. J Biophotonics [Accepted]
(2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763.
(2018) Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin. BMC System Biol 12(1), 88.
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.
(2018) Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell 5(7), 300-326. (Review)
(2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. eLife 7, e40969.
(2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51.
(2018) Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nat Microbiol 3(7), 791-803.
(2018) The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLoS Genet 14(10), e1007762.
(2018) Microbial interactions trigger the production of antibiotics. Curr Opin Microbiol 45, 117-123. (Review)
(2018) Generation of an arginine-tRNA-adapted Saccharomyces cerevisiae strain for effective heterologous protein expression. Curr Genet 64(3), 589-598.
(2018) Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. PLOS ONE 13(3), e0185706.
(2018) Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis. ACS Chem Biol 13(9), 2508-2512.
(2018) Proteomics of Aspergillus fumigatus conidia-containing phagolysosomes identifies processes governing immune evasion. Mol Cell Proteomics 17(6), 1084-1096.
(2018) Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. Nature 555(7696), 382-386.
(2018) β-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells. Virulence 29, 1-13.
(2018) Arabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis-specific proteins. PLoS One 13(12), e0209658.
(2018) Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus. MBio 9(5), e01557-18.
(2018) UV-Raman spectroscopic identification of fungal spores important for respiratory diseases. Anal Chem 90(15), 8912-8918.
(2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844.
(2017) Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biol 18(1), 28.
(2017) The CCAAT-binding complex (CBC) in Aspergillus species. Biochim Biophys Acta 1860(5), 560-570. (Review)
(2017) A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity. MBio 8(4), e01504-e01516.
(2017) Arylmethylamino steroids as antiparasitic agents. Nat Commun 8, 14478.
(2017) Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence. Cell Microbiol 19(12),
(2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882.
(2017) Rewiring of the Austinoid Biosynthetic Pathway in Filamentous Fungi. ACS Chem Biol 12(12), 2927-2933.
(2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16.
(2017) Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection. Mol Cell Proteomics 16(12), 2184-2198.
(2017) Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus. Antimicrob Agents Chemother 61(11), e00978-17.
(2017) Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprG/ΔPrtT Protease-Deficient Mutants. Front Microbiol 8, 2490.
(2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234.
(2017) Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing. ACS Synth Biol 6(1), 62-68.
(2016) Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microbe 19(1), 79-90.
(2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12, 419-424.
(2016) Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167(4), 1067-1078.e16.
(2016) Mitogen activated protein kinases SakA (HOG1) and MpkC collaborate for Aspergillus fumigatus virulence. Mol Microbiol 100(5), 841-859.
(2016) Melanin targets LC3-associated phagocytosis (LAP): A novel pathogenetic mechanism in fungal disease. Autophagy 12(5), 888-889. (Review)
(2016) Awakening of Fungal Secondary Metabolite Gene Clusters In: Schmoll M., Dattenböck C. (eds.) Gene Expression Systems in Fungi: Advancements and Applications (Part II), pp. 253-273. Springer, Cham. ISBN: 978-3-319-27949. (Review)
(2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLOS Pathog 12(7), e1005775.
(2016) The crystal structure of peroxiredoxin Asp f3 provides mechanistic insight into oxidative stress resistance and virulence of Aspergillus fumigatus. Sci Rep 6, 33396.
(2016) Draft genome sequences of fungus Aspergillus calidoustus. Genome Announc 4(2), e00102-16.
(2016) SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus PLOS Pathog 12(9), e1005899.
(2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817.
(2016) Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies. Proteomics Clin Appl 10(9-10), 910-921. (Review)
(2016) The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae. Curr Genet 63(1), 103-116.
(2016) HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence. PLOS ONE 11(3), e0150701.
(2016) The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus Mol Microbiol 101(1), 92-108.
(2016) Immunoproteomic analysis of antibody responses to extracellular proteins of Candida albicans revealed the importance of glycosylation for antigen recognition. J Proteome Res 15(8), 2394-2406.
(2016) Regulation and Role of Fungal Secondary Metabolites. Annu Rev Genet 50, 371-392. (Review)
(2016) Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper Fungal Biol Biotechnol 3, 6. (Review)
(2016) Hyperspectral imaging using intracellular spies: quantitative real-time measurement of intracellular parameters in vivo during interaction of the pathogenic fungus Aspergillus fumigatus with human monocytes PLOS ONE 11(10), e0163505.
(2016) An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35. Appl Environ Microbiol 82(12), 3481-3492.
(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807.
(2016) Gliotoxin- bane or boon? Environ Microbiol 18(4), 1096-1109. (Review)
(2016) Bacteria induce pigment formation in the basidiomycete Serpula lacrymans. Environ Microbiol 18, 5218-5227.
(2016) Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 15(5), 1580-1591.
(2016) Identification and characterization of a novel Aspergillus fumigatus rhomboid family putative protease RbdA involved in hypoxia sensing and virulence. Infect Immun 84(6), 1866-1878.
(2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol 102(2), 321-335.
(2015) Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus. PLOS One 10(9), e0136932.
(2015) Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer. Cytotherapy 17(10), 1396-1405.
(2015) Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold infection. Am J Respir Crit Care Med 191(3), 348-352.
(2015) Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation. Proteomics 15(13), 2230-2243.
(2015) Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLOS Genet 11(7), e1005297.
(2015) Interference of Aspergillus fumigatus with the immune response. Semin Immunopathol 37(2), 141-152. (Review)
(2015) Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation. Environ Microbiol 17(8), 2858-2869.
(2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), pii: e01439-14.
(2015) Draft Genome Sequence of the Fungus Penicillium brasilianum MG11. Genome Announc 3(5), e00724-15.
(2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10), 6058-6070.
(2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600.
(2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally.
(2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162.
(2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161.
(2015) Synthetic Biology of Fungal Natural Products Front. Microbiol. 6, 775. (Review)
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631.
(2015) Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters. Front Microbiol 6, 299. (Review)
(2015) The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. Front Microbiol 6, 325. (Review)
(2015) Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). Antimicrob Agents Chemother 59(9), 5145-5153.
(2014) Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi. Mucosal Immunol 7(4), 916-928.
(2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi-parameter characterization of specific conventional and regulatory CD4+ T cells. Journal of Immunology 197(7), 3332-3343.
(2014) Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response. Infect Immun 82(8), 3141-3153.
(2014) Bacillus subtilis attachment to Aspergillus niger hyphae results in mutually altered metabolism. Environ Microbiol 17(6), 2099-2113.
(2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108.
(2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19), 2261-2276.
(2014) Opposed Effects of Enzymatic Gliotoxin N-and S-Methylations J.Am.Chem.Soc. (136), 11674-11679.
(2014) Functional genomics to characterize opportunistic pathogens. In: Nowrousian M (ed.) The Mycota 13, pp. 321-347. Springer. ISBN: 9783642452178.
(2014) The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus. Mol Microbiol 93(3), 539-553.
(2014) Draft genome sequence of Streptomyces iranensis. Genome Announc 2(4), e00616-14.
(2014) Data-driven systems biology of fungal infections. In: Sullivan D, Moran GP (eds.) Human pathogenic Fungi: Molecular biology and pathogenic mechanisms Caister Academic Press, Norfolk, U.K.. ISBN: 978-1-908230-44.
(2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as important contributor to hypoxic survival. Eukaryot Cell 13(9), 1241-1253.
(2014) Characterisation of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and impact on virulence. Frontiers in Microbiology 5, 469.
(2014) Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet Biol 70C, 42-67.
(2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8), 2221-2224.
(2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679.
(2014) Human and plant fungal pathogens: the role of secondary metabolites. PLOS Pathog 10(1), e1003859. (Review)
(2014) Fungal-actinomycete interactions – wakening of silent fungal secondary metabolism gene clusters via interorganismic interactions. In: Osbourn A, Goss RJ, Carter GT (eds.) Natural Products: Discourse, Diversity, and Design pp. 147-158. Wiley-Blackwell. ISBN: 978-1-118-29806.
(2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial Mucorales (Mucoromycotina). PLOS Genetics 10(8), e1004496.
(2014) Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem Biol 21(4), 502-508.
(2013) Deletion of the α-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of Aspergillus fumigatus. PLOS Pathog 9(11), e1003716-e1003716.
(2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11(1), 21-32. (Review)
(2013) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide Soft Matter 3(9), 715-726.
(2013) Star-shaped drug carriers for doxorubicin with POEGMA and POEtOxMA brush-like shells: a structural, physical, and biological comparison. Biomacromolecules 14(8), 2536-2548.
(2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942.
(2013) Investigation of Aspergillus fumigatus biofilm formation by various Front Microbiol 4, 13-13.
(2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109.
(2013) Engineering fungal secondary metabolism: a roadmap to novel compounds. J Biotechnol 163(2), 179-183. (Review)
(2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095.
(2013) Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol 4, 141.
(2013) Developmental history: bendamustine yesterday, today, tomorrow. Onkologie 36 Suppl 1, 2-10.
(2012) Regio- and stereoselective oxidative phenol coupling in Aspergillus niger. Angew Chem Int Ed Engl 51(39), 9788-9791.
(2012) The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells. Eukaryot Cell 11(5), 673-682.
(2012) Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol 3, 440.
(2012) Systems biology of fungal infection. Front Microbiol 3, 108.
(2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10), 1757-1768.
(2012) Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6, 6.
(2012) Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio 3(5), e00259.
(2012) Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC Genomics 13, 519.
(2012) Regulatory cross talk and microbial induction of fungal secondary metabolite gene clusters. Methods Enzymol 517, 325-341.
(2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71.
(2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068.
(2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472.
(2012) Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158(Pt 6), 1634-1644.
(2012) Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans - The role of a putative dehydrin. J Proteomics 75(13), 4038-4049.
(2011) On the way toward systems biology of Aspergillus fumigatus infection. Int J Med Microbiol 301(5), 453-459.
(2011) Pathobiology of human-pathogenic fungi. Int J Med Microbiol 301(5), 367-367.
(2011) Fungal secondary metabolites - strategies to activate silent gene clusters. Fungal Genet Biol 48(1), 15-22.
(2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7.
(2011) Phagocyte responses towards Aspergillus fumigatus. Int J Med Microbiol 301(5), 436-444.
(2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53.
(2011) Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence. PLOS One 6(10), e26604.
(2011) Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics. Int J Med Microbiol 301(5), 368-377.
(2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLOS ONE 6(5), e19591, *authors contributed equally.
(2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287.
(2011) FungiFun: A web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol 48(4), 353-358.
(2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325.
(2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42), 9843-9847.
(2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839.
(2011) Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway. Front Microbiol / Fungi and their interactions 2, 96.
(2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5), 2508-2524.
(2011) Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8), 1130-1148.
(2011) Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol 301(7), 602-611.
(2010) Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics 11, 32.
(2010) Missing values in gel-based proteomics. Proteomics 10(6), 1202-1211.
(2010) Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5. Infect Immun 78(8), 3585-3594.
(2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24), 8143-8149.
(2010) Interaction of phagocytes with filamentous fungi. Curr Opin Microbiol 13(4), 409-415.
(2010) Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLOS Pathog 6(4), e1000873.
(2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107.
(2010) Heptahelical receptors GprC and GprD of Aspergillus fumigatus are essential regulators of colony growth, hyphal morphogenesis, and virulence. Appl Environ Microbiol 76(12), 3989-3998.
(2010) Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability. Mol Microbiol 76(5), 1205-1221.
(2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29), 10136-10141.
(2010) HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLOS Pathog 6(9), e1001124-e1001124.
(2010) Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res 9(7), 3427-3442.
(2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4), 1098-1113.
(2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460(7259), 1117-1121.
(2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70(15-16), 1801-1811.
(2009) Proteome analysis for pathogenicity and new diagnostic markers for Aspergillus fumigatus. Med Mycol 47 Suppl 1, S248-S254.
(2009) Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genet Biol 46(4), 287-298.
(2009) Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol 75(2), 493-503.
(2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34), 14558-14563.
(2009) Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans. Eukaryot Cell 8(3), 421-423.
(2009) The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet Biol 46(12), 909-918.
(2009) Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics 9(5), 1407-1415.
(2008) Activation of fungal silent gene clusters: a new avenue to drug discovery. Prog Drug Res 66, 1, 3-1,12.
(2008) Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry. Exp Dermatol 17(4), 356-361.
(2008) Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus. Appl Environ Microbiol 74(15), 4923-4933.
(2008) Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol 10(1), 134-148.
(2008) Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA. Mol Genet Genomics 280(6), 483-495.
(2008) SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol 70(1), 27-43.
(2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70(2), 445-461.
(2008) The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal Genet Biol 45(5), 618-627.
(2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLOS Pathog 3(2), e13.
(2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4), 213-217.
(2007) Functional characterization of the Aspergillus fumigatus calcineurin. Fungal Genet Biol 44(3), 219-230.
(2007) Discovery of gene regulatory networks in Aspergillus fumigatus Lect Notes Bioinf 4366,
(2007) Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13), 3157-3168.
(2007) The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell 6(12), 2290-2302.
(2007) Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 9(2), 368-381.
(2007) Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. Infect Immun 75(3), 1237-1244.
(2007) The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis. Arch Microbiol 188(1), 69-79.
(2007) The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response. J Biol Chem 282(37), 27259-27269.
(2007) Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2), 250-254.
(2006) The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5(1), 207-211.
(2006) Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Curr Genet 50(1), 32-44.
(2006) Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development. Fungal Genet Biol 43(7), 476-489.
(2006) Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. Appl Environ Microbiol 72(4), 2957-2970.
(2006) Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet 49(3), 178-189.
(2006) Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol 62(1), 292-302.
(2006) Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus. Arch Microbiol 186(5), 345-355.