Zoltán Cseresnyés

Dr. Zoltán Cseresnyés

Applied Systems Biology · PolyTarget

Phone: +49 3641 532-1532 Fax: +49 3641 532-2532 Email: zoltan.cseresnyes@leibniz-hki.de

Main Research Areas
  • Intravital 2-photon microscopy of the immune system
  • Software development for automated and advanced image analysis and model-based simulations
  • Image-based Systems Biology
Curriculum vitae

Professional Career

since 2016 Research associate, imaging and image analysis specialist at the Hans Knoell Institute, Jena
2016-2016 Microscopy and imaging specialist at the Deutsches Rheuma-Forschungszentrum (DRFZ) and the Beuth Hochschule, Berlin
2012-2016 Microscopy and imaging specialist in the JIMI (Joint Intravital Microscopy and Imaging) project at the Deutsches Rheuma-Forschungszentrum, Max Delbrück Center (Berlin) and at the Hans Knoell Institute, Jena
2010-2012 Research associate and Co-manager of the Confocal and 2-Photon Microscopy Core Facility at Max Delbrück Center for Molecular Medicine in Berlin
2007-2010 Imaging Facility manager in the Department of Zoology at the University of Cambridge (GB)
1994-2007 Research associate and confocal imaging specialist in the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (USA)
1991-1994 Research associate in the Department of Physiology at the School of Medicine at Debrecen University (HU)
1985-1991 Research associate in the Department of Solid State Physics at Debrecen University (HU)
Publications

Böttcher B, Hoffmann B, Garbe E, Weise T, Cseresnyés Z, Brandt P, Dietrich S, Driesch D, Figge MT, Vylkova S (2020) The transcription factor Stp2 is important for Candida albicans biofilm establishment and sustainability. Front Microbiol 11, 794. Details PubMed Open Access PDF

Cseresnyes Z*, Hassan MIA*, Dahse HM, Voigt K, Figge MT; *shared first authors (2020) Quantitative impact of cell membrane fluorescence labeling on phagocytosis measurements in confrontation assays. Front Microbiol 11, 1193. Details PubMed Open Access PDF

Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS (2020) Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model. Biofabrication 12(2), 025012. Details PubMed Open Access PDF

Drost N*, Houtman J*, Cseresnyés Z, Niesner R, Rinnenthal JL, Miller KR, Prokop S**, Heppner FL**; * authors contributed equally; corresponding authors; ** authors contributed equally (2020) The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin. Sci Rep 10(1), 7152. Details PubMed Open Access PDF

Hassan MIA, Kruse J, Krüger T, Dahse HM, Cseresnyés Z, Blango MG, Slevogt H, Hörhold F, Ast V, König R, Figge MT, Kniemeyer O, Brakhage AA, Voigt K (2020) Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages. Environ Microbiol [Epub ahead of print] Details PubMed Open Access

Medyukhina A*, Blickensdorf M*, Cseresnyés Z, Ruef N, Stein JV, Figge MT; *authors contributed equally (2020) Dynamic spherical harmonics approach for shape classification of migrating cells. Sci Rep 10(1), 6072. Details PubMed Open Access PDF

Schicke E, Cseresnyes Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S, Swiczak F, Schmidtke M, Koch M, Glück B, Schacke M, Heller R, Mosig AS, Figge MT, Ehrhardt C, Löffler B, Deinhardt-Emmer S (2020) Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages. Microorganisms 8(4), 577. Details PubMed Open Access PDF Supplement

Schmidt F, Thywißen A, Goldmann M, Cunha C, Cseresnyés Z, Schmidt H, Rafiq M, Galiani S, Gräler MH, Chamilos G, Lacerda JF, Campos Jr A, Eggeling C, Figge MT, Heinekamp T, Filler SG, Carvalho A, Brakhage AA (2020) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Cell Reports 32(7), 108017. Details PubMed PDF

Shopova IA, Belyaev I, Dasari P, Jahreis S, Stroe MC, Cseresnyés Z, Zimmermann AK, Medyukhina A, Svensson CM, Krüger T, Szeifert V, Nietzsche S, Conrad T, Blango MG, Kniemeyer O, von Lilienfeld-Toal M, Zipfel PF, Ligeti E, Figge MT, Brakhage AA (2020) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. mBio 11(2), e00596-20. Details PubMed Open Access PDF Supplement

Hassan MIA*, Cseresnyes Z*, Al-Zaben N, Dahse HM, Vilela de Oliveira RJ, Walther G, Voigt K**, Figge MT**; *shared first authors; ** authors contributed equally (2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol 21(12), 4563-4581. Details PubMed Open Access PDF Supplement

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. Details PubMed

Cseresnyes Z*, Kraibooj K*, Figge MT, *authors contributed equally (2018) Hessian-based quantitative image analysis of host- pathogen confrontation assays. Cytometry A 93(3), 346-356. Details PubMed Open Access PDF

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement

Kriegel FL, Köhler R, Bayat Sarmadi J, Bayerl S, Hauser AE, Niesner R, Luch A*, Cseresnyés Z*, *authors contributed equally (2018) Morphology-based distinction between healthy and pathological cells utilizing fourier transforms and self-organizing maps. J Vis Exp 140, e58543. Details PubMed Open Access

Kriegel FL, Köhler R, Bayat-Sarmadi J, Bayerl S, Hauser AE, Niesner R, Luch A, Cseresnyes Z (2018) Cell shape characterization and classification with discrete fourier transforms and self-organizing maps. Cytometry A 93(3), 323-333. Details PubMed Open Access PDF

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed Open Access

Keller B, Cseresnyés Z, Stumpf I, Wehr C, Fliegauf M, Bulashevska A, Usadel S, Grimbacher B, Rizzi M, Eibel H, Niesner R, Warnatz K (2017) Disturbed canonical nuclear factor of κ light chain signaling in B cells of patients with common variable immunodeficiency. J Allergy Clin Immunol 139(1), 220-231. Details PubMed

Bayerl SH, Niesner R, Cseresnyés Z, Radbruch H, Pohlan J, Brandenburg S, Czabanka MA, Vajkoczy P (2016) Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia. Glia 64(7), 1210-1226. Details PubMed

Radbruch H, Bremer D, Guenther R, Cseresnyés Z, Lindquist R, Hauser AE, Niesner R (2016) Ongoing oxidative stress causes subclinicalneuronal dysfunction in the recovery phase of EAE. Front Immunol 7(92), Details PubMed Open Access PDF

Zehentmeier S, Cseresnyés Z, Escribano Navarro J, Niesner RA, Hauser AE (2015) Automated quantification of hematopoietic cell-stromal cell interactions in histological images of undercalcified bone. JoVE 98, 52544. Details

Cseresnyés Z, Oehme L, Andresen V, Sporbert A, Hauser AE, Niesner R (2014) Highly resolved intravital striped-illumination microscopy of germinal centers. J Vis Exp (86), Details PubMed

Heinig K, Gätjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K, Niesner RA, Cseresnyés Z, Hauser AE, Lenz P, Hehlgans T, Brink R, Westermann J, Dörken B, Lipp M, Lenz G, Rehm A, Höpken UE (2014) Access to follicular dendritic cells Is a pivotal step in murine chronic lymphocyticleukemia B-cell activation and proliferation. Cancer Discov 4(12), 1448-1465. Details PubMed

Zehentmeier S, Roth K, Cseresnyés Z, Sercan Ö, Horn K, Niesner RA, Chang HD, Radbruch A, Hauser AE (2014) Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. Eur J Immunol 44(8), 2306-2317. Details PubMed Open Access

Sporbert A, Cseresnyés Z, Heidbreder M, Domaing P, Hauser S, Kaltschmidt B, Kaltschmidt C, Heilemann M, Widera D (2013) Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots. PLOS One 8(5), e64023. Details PubMed Open Access PDF

Veerkamp J, Rudolph F, Cseresnyés Z, Priller F, Otten C, Renz M, Schaefer L, Abdelilah-Seyfried S (2013) Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Dev Cell 24(6), 660-667. Details PubMed Open Access PDF

Andresen V, Pollok K, Rinnenthal JL, Oehme L, Günther R, Spiecker H, Radbruch H, Gerhard J, Sporbert A, Cseresnyés Z, Hauser AE, Niesner R (2012) High-resolution intravital microscopy. PLOS One 7(12), e50915. Details PubMed

Cseresnyés Z, Sporbert A, Kriegel F (2012) Core Facility Management: A Customized Web-based Toolbox for Managing Microscopy Core Facilities. Imaging & Microscopy , Details Open Access

Kloepper JE, Bíró T, Paus R, Cseresnyés Z (2010) Point scanning confocal microscopy facilitates 3D human hair follicle imaging in tissue sections. Exp Dermatol 19(7), 691-694. Details PubMed

Bischoff M, Cseresnyés Z (2009) Cell rearrangements, cell divisions and cell death in a migrating epithelial sheet in the abdomen of Drosophila. Development 136(14), 2403-2411. Details PubMed

Cseresnyés Z, Schwarz U, Green CM (2009) Analysis of replication factories in human cells by super-resolution light microscopy. BMC Cell Biol 10(88), Details PubMed

Hernández-Ochoa E O, Cseresnyés Z, Schneider M F (2007) Ca2+ signal summation and NFATc1 nuclear translocation in sympathetic ganglion neurons during repetitive action potentials induced by M-channel inhibition. Cell Calcium 41(6), 559-571. Details

Shen T, Cseresnyés Z, Liu Y, Randall WR, Schneider MF (2007) Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres. J Physiol 579(Pt 2), 535-551. Details PubMed

Shen T, Liu Y, Cseresnyés Z, Hawkins A, Randall WR, Schneider MF (2006) Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol Biol Cell 17(4), 1570-1582. Details PubMed

Cseresnyés Z, Schneider MF (2004) Peripheral hot spots for local Ca2+ release after single action potentials in sympathetic ganglion neurons. Biophys J 86(1 Pt 1), 163-181. Details PubMed

Thomas S, Zinter R, Cseresnyés Z, Hutter-Paier B, Hofmeister A (2003) Structured light imaging: An accessible alternative to confocal imaging. Am Biotechnol Lab 21(11), 14-16. Details

Liu Y, Cseresnyés Z, Randall WR, Schneider MF (2001) Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. J Cell Biol 155(1), 27-39. Details PubMed

McDonough SI, Cseresnyés Z, Schneider MF (2000) Origin sites of calcium release and calcium oscillations in frog sympathetic neurons. J Neurosci 20(24), 9059-9070. Details PubMed

Cseresnyés Z, Bustamante AI, Schneider MF (1999) Caffeine-induced [Ca2+] oscillations in neurones of frog sympathetic ganglia. J Physiol 514(Pt 1), 83-99. Details PubMed

Cseresnyés Z, Bustamante AI, Klein MG, Schneider MF (1997) Release-activated Ca2+ transport in neurons of frog sympathetic ganglia. Neuron 19(2), 403-419. Details PubMed

Rusznák Z, Cseresnyés Z, Sipos I, Magyar J, Kovács L, Szücs G (1996) Characteristics of the ventricular transient outward potassium current in genetic rodent models of diabetes. Gen Physiol Biophys 15(3), 225-238. Details PubMed

Cseresnyés Z, Rusznák Z, Bozsányi A, Magyar J, Szücs G, Kovács L (1995) Three different gating models for inactivation of the Ito in ventricular myocytes of rats and mice. Gen Physiol Biophys 14(4), 259-276. Details PubMed

Magyar J, Cseresnyés Z, Rusznák Z, Sipos I, Szücs G, Kovács L (1995) Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. Gen Physiol Biophys 14(3), 191-201. Details PubMed

Kiss S, Cseresnyés Z, Harangozó IZ (1994) The study of internal friction in metal-metal layered materials. J Alloys Compd 211-212, 498-502. Details

Kiss S, Cseresnyés Z, Posgay G, Tompa K, Lovas A (1993) Effect of H and Cu on the damping and modulus of amorphous NiZr alloys. Mater Sci Forum 119-121, 505-510. Details

Kiss S, Harangozó IZ, Cseresnyés Z, Kedves FJ (1990) The influence of some alloying elements on the grain boundary relaxation of alimunium In: Defect and diffusion forum 66-69, pp. 1425-1430.Trans Tech Publications Ltd. Details

Harangozo I, Kedves F, Kiss S, Hordos M, Cseresnyés Z, Posgay G (1987) Internal friction of Cu-Zn-Al sape memory alloys above Martensitic transformation. J. Phys. Colloques 48, C8-541-C8-546. Details PDF

Posgay G, Kiss S, Kedves F, Harangozo I, Cseresnyés Z (1987) Stress dependent internal friction and modulus changes in iron-based metallic glasses. J. Phys. Colloques 48, C8-447-C8-450. Details PDF

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