Hans-Martin Dahse

Dr. Hans-Martin Dahse

Infection Biology

Phone: +49 3641 532-1176 Fax: +49 3641 532-2176 Email: hans-martin.dahse@leibniz-hki.de

Topics
Publications

Hassan MIA*, Cseresnyes Z*, Al-Zaben N, Dahse H-M, Vilela de Oliveira RJ, Walther G, Voigt K°, Figge MT°; * authors contributed equally; °corresponding authors, authors contributed equally (2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol [Epub ahead of print] Details PubMed Open Access PDF Supplement

Hassan MIA, Cseresnyes Z, Al-Zaben N, Dahse HM, Vilela de Oliveira RJ, Walther G, Voigt K, Figge MT (2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol [Accepted] Details

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K (2019) Arylmethylamino steroids as antiparasitic agents. Nat Commun 10(1), 2997. Details PubMed

Schieferdecker S, Shabuer G, Letztel A-C, Urbansky B, Ishida-Ito M, Ishida K, Cyrulies M, Dahse HM, Pidot S, Hertweck C (2019) Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria ACS Chem. Biology 14(7), 1490-1497. Details PubMed

Sree KS, Dahse HM, Chandran JN, Schneider B, Jahreis G, Appenroth KJ (2019) Duckweed for Human Nutrition: No Cytotoxic and No Anti-Proliferative Effects on Human Cell Lines. Plant Foods Hum Nutr 74(2), 223-224. Details PubMed

Trottmann F, Franke J, Richter I, Ishida K, Cyrulies M, Dahse HM, Regestein L, Hertweck C (2019) Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species Angew Chem Int Ed Engl , Details PubMed

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement

Dudek B, Schnurrer F, Dahse HM, Paetz C, Warskulat A-C, Weigel C, Voigt K, Schneider B (2018) Formation of Nudicaulins In Vivo and In Vitro and the Biomimetic Synthesis and Bioactivity of O-Methylated Nudicaulin Derivatives Molecules 12(13), 3357. Details PubMed

Guo H, Schmidt A, Stephan P, Raguž L, Braga D; Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins ChemBioChem 19(21), 2307-2311. Details PubMed

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed

Becker T, Pasteels J, Weigel C, Dahse HM, Voigt K, Boland W (2017) A tale of four kingdoms - isoxazolin-5-one- and 3-nitropropanoic acid-derived natural products Natural Product Reports 34(4), 343-360. Details PubMed

Guo H, Benndorf R, Leichnitz D, Klassen JL, Vollmers J, Görls H, Steinacker M, Weigel C, Dahse HM, Kaster AK, de Beer ZW, Poulsen M, Beemelmanns C (2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2 Chem. Eur J 23(39), 9338-9345. Details PubMed

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K (2017) Arylmethylamino steroids as antiparasitic agents. Nat Commun 8, 14478. Details PubMed

Macabeo APG, Letada AG, Budde S, Faderl C, Dahse HM, Franzblau SG, Alejandro GJD, Pierens GK, Garson MJ (2017) Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba. J Nat Prod 80(12), 3319-3323. Details PubMed

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator J Neuroinflammation 14(1), 4. Details PubMed

Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C (2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed

Ueberschaar N, Meyer F, Dahse HM, Hertweck C (2016) Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides. Chem Commun (Camb) 52(27), 4894-4897. Details PubMed

Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse H-M, Brakhage AA, Hoffmeister D (2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600. Details PubMed

Korp J, König S, Schieferdecker S, Dahse H-M, König G M, Werz O, Nett M (2015) Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors. ChemBioChem 16, 2445-2450. Details

Schieferdecker S, König S, Koeberle A, Dahse H-M, Werz O, Nett M (2015) Myxochelins target human 5-lipoxygenase. J Nat Prod 78(2), 335-338. Details PubMed

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674. Details PubMed

Sugimoto Y, Ishida K, Traitcheva N, Busch B, Dahse HM, Hertweck C (2015) Freedom and constraint in engineered noncolinear polyketide assembly lines Chem Biol 22(2), 229-240. Details PubMed

Tyagi C, Bathke J, Goyal S, Fischer M, Dahse HM, Chacko S, Becker K, Grover A (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence Int J Biochem Cell Biol 61, 72-80. Details PubMed

Bohnert M, Nützmann HW, Schroeckh V, Horn F, Dahse HM, Brakhage AA, Hoffmeister D (2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108. Details PubMed

Bohnert M, Scherer O, Wiechmann K, König S, Dahse HM, Hoffmeister D, Werz O (2014) Melleolides induce rapid cell death in human primary monocytes and cancer cells. Bioorg Med Chem 22, 3856-3861. Details PubMed

Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. Details PubMed

Kirchhoff KN, Klingelhöfer I, Dahse HM, Morlock G, Wilke T (2014) Maturity-related changes in venom toxicity of the freshwater stingray Potamotrygon leopoldi. Toxicon 92, 97-101. Details PubMed

Kraibooj K*, Park HR*, Dahse HM, Skerka C, Voigt K⁺, Figge MT⁺ (2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally. Details PubMed Open Access

Macabeo AP, Martinez FP, Kurtan T, Toth L, Mandi A, Schmidt S, Heilmann J, Alejandro GJ, Knorn M, Dahse HM, Franzblau SG (2014) Tetrahydroxanthene-1,3(2H)-dione Derivatives from Uvaria valderramensis. J Nat Prod 77(12), 2711-2715. Details PubMed

Schieferdecker S, König S, Weigel C, Dahse HM, Werz O, Nett M (2014) Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax. Chem Eur J 20, 15933-15940. Details PubMed

Schwenk D, Nett M, Dahse H-M, Horn U, Blanchette RA, Hoffmeister D (2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663. Details PubMed

Meyer F, Ueberschaar N, Dahse HM, Hertweck C (2013) Synthesis and biological evaluation of hydrazidomycin analogues. Bioorg Med Chem Lett 23(22), 6043-6045. Details PubMed

Schrader FC, Glinca S, Sattler JM, Dahse HM, Afanador GA, Prigge ST, Lanzer M, Mueller AK, Klebe G, Schlitzer M (2013) Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents. ChemMedChem 8(3), 442-461. Details PubMed

Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D (2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79, 6670-6676. Details PubMed

Ueberschaar N, Dahse HM, Bretschneider T, Hertweck C (2013) Rational design of an apoptosis-inducing photoreactive DNA intercalator. Angew Chem Int Ed Engl 52(24), 6185-6189. Details PubMed

Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C (2013) Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. J Am Chem Soc 135(46), 17408-17416. Details PubMed

Bauer K, Dürrwald R, Schlegel M, Pfarr K, Topf D, Wiesener N, Dahse HM, Wutzler P, Schmidtke M (2012) Neuraminidase inhibitor susceptibility of swine influenza A viruses isolated in Germany between 1981 and 2008. Med Microbiol Immunol 201(1), 61-72. Details PubMed

Ding L, Dahse HM, Hertweck C (2012) Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum. J Nat Prod 75(4), 617-621. Details PubMed

Scherlach K, Brendel N, Ishida K, Dahse HM, Hertweck C (2012) Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Org Biomol Chem 10(30), 5756-5759. Details PubMed

Heinrich S, Altenkämper M, Bechem B, Perruchon J, Ortmann R, Dahse HM, Wang Y, Lanzer M, Schlitzer M (2011) 2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites. Eur J Med Chem 46(4), 1331-1342. Details PubMed

Kusebauch B, Brendel N, Kirchner H, Dahse HM, Hertweck C (2011) Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line. Chembiochem 12(15), 2284-2288. Details PubMed

Kusebauch B, Scherlach K, Kirchner H, Dahse HM, Hertweck C (2011) Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives. ChemMedChem 6(11), 1998-2001. Details PubMed

Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42), 9843-9847. Details PubMed

Scherlach K, Sarkar A, Schroeckh V, Dahse HM, Roth M, Brakhage AA, Horn U, Hertweck C (2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839. Details PubMed

Thywißen A, Heinekamp T, Dahse HM, Schmaler-Ripcke J, Nietzsche S, Zipfel PF, Brakhage AA (2011) Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway. Front Microbiol / Fungi and their interactions 2, 96. Details PubMed

Wartenberg D, Lapp K, Jacobsen ID, Dahse HM, Kniemeyer O, Heinekamp T, Brakhage AA (2011) Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol 301(7), 602-611. Details PubMed

Abdou R, Scherlach K, Dahse HM, Sattler I, Hertweck C (2010) Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa. Phytochemistry 71(1), 110-116. Details PubMed

Gomes PB, Nett M, Dahse HM, Hertweck C (2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464. Details PubMed

Scherlach K, Schuemann J, Dahse HM, Hertweck C (2010) Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans. J Antibiot (Tokyo) 63(7), 375-377. Details PubMed

Werneburg M, Busch B, He J, Richter ME, Xiang L, Moore BS, Roth M, Dahse HM, Hertweck C (2010) Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc 132(30), 10407-10413. Details PubMed Open Access

Laube T, Bernet A, Dahse HM, Jacobsen ID, Seifert K (2009) Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones. Bioorg Med Chem 17(4), 1422-1427. Details PubMed

Ndejouong Ble S, Sattler I, Dahse HM, Kothe E, Hertweck C (2009) Isoflavones with unusually modified B-rings and their evaluation as antiproliferative agents. Bioorg Med Chem Lett 19(22), 6473-6476. Details PubMed

Peschel G, Dahse HM, Konrad A, Wieland GD, Mueller PJ, Martin DP, Roth M (2008) Growth of keratinocytes on porous films of poly(3-hydroxybutyrate) and poly(4-hydroxybutyrate) blended with hyaluronic acid and chitosan. J Biomed Mater Res A 85(4), 1072-1081. Details PubMed

Ivanova V, Kolarova M, Aleksieva K, Dornberger KJ, Haertl A, Moellmann U, Dahse HM, Chipev N (2007) Sanionins: anti-inflammatory and antibacterial agents with weak cytotoxicity from the Antarctic moss Sanionia georgico-uncinata. Prep Biochem Biotechnol 37(4), 343-352. Details PubMed

Jütten P, Schumann W, Härtl A, Dahse HM, Gräfe U (2007) Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem 50(15), 3661-3666. Details PubMed

Wangun HV, Dahse HM, Hertweck C (2007) Epicoccamides B-D, glycosylated tetramic acid derivatives from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa. J Nat Prod 70(11), 1800-1803. Details PubMed

Franke K, Nguyen M, Härtl A, Dahse HM, Vogl G, Würzner R, Zipfel PF, Künkel W, Eck R (2006) The vesicle transport protein Vac1p is required for virulence of Candida albicans. Microbiology 152(Pt 10), 3111-3121. Details PubMed

Scherlach K, Partida-Martinez LP, Dahse HM, Hertweck C (2006) Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. J Am Chem Soc 128(35), 11529-11536. Details PubMed

Johne S, Watzke R, Meusel W, Möllmann U, Härtl A, Dahse HM, Matthes B, Seifert K (2005) Biotechnological production and bioactivities of mollisin and two new, structurally related fungal naphthoquinone metabolites. Chem Biodivers 2(8), 1109-1115. Details PubMed