Teresa Lehnert

Dr. Teresa Lehnert

Applied Systems Biology

Main Research Areas
  • computer simulation of virtual infection models with Candida albicans 
  • population-based, state-based and agent-based modelling of immune responses to C. albicans 
  • estimation of a priori unknown model parameter using global optimization algorithms
Topics
Curriculum vitae

Professional Career

since 2016 Postdoctoral researcher in the group Applied Systems Biology at Hans Knöll Institute
2017 PhD in Bioinformatics at the Friedrich Schiller University Jena
2011 Diploma in Bioinformatics at the Friedrich Schiller University Jena
Publications

Lehnert T*, Leonhardt I*, Timme S, Thomas-Rüddel D, Bloos F, Sponholz C, Kurzai O, Figge MT** ,Hünniger K**; * shared first authors; ** authors contributed equally (2020) Ex vivo Immune profiling in patient blood enables quantification of innate immune effector functions. bioRxiv , Details Open Access PDF

Sreekantapuram S*, Lehnert T*, Prauße MT, Berndt A, Berens C, Figge MT**, Jacobsen ID**; * authors contributed equally; ** corresponding authors (2020) Dynamic interplay of host and pathogens in an avian whole blood model. Front Immunol 11, 500. Details PubMed Open Access PDF

Tille A, Lehnert T, Zipfel PF, Figge MT (2020) Quantification of factor H mediated self versus non-self discrimination by mathematical modeling. Front Immunol 11, 1911. Details

Prauße MTE, Lehnert T, Timme S, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560. Details PubMed Open Access PDF Supplement

Timme S, Lehnert T, Prauße MTE, Hünniger K, Leonhardt I, Kurzai O, Figge MT (2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667. Details PubMed Open Access PDF Supplement

Lehnert T, Figge MT (2017) Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling. Front Immunol 8, 1692. Details PubMed Open Access PDF Supplement

Duggan S, Essig F, Hünniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Häder A, Jacobsen ID, Martin R, Figge MT, Kurzai O (2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276. Details PubMed

Hünniger K, Bieber K, Martin R, Lehnert T, Figge MT, Löffler J, Guo R, Riedemann N, Kurzai O (2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210. Details PubMed

Lehnert T*, Timme S*, Pollmächer J, Hünniger K, Kurzai O, Figge MT (2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally. Details PubMed Open Access

Hünniger K*, Lehnert T*, Bieber K, Martin R, Figge MT⁺, Kurzai O⁺ (2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally. Details PubMed Open Access

Mech F, Wilson D, Lehnert T, Hube B, Figge MT (2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed

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