Dr. Daniel H. Scharf
(2020) N-Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase Chembiochem [Epub ahead of print]
(2018) Reconstitution of enzymatic carbon-sulfur bond formation reveals detoxification-like strategy in fungal toxin biosynthesis. ACS Chem Biol 13(9), 2508-2512.
(2017) Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis. Chem Rev 117(8), 5521-5577. (Review)
(2017) A nonredundant phosphopantetheinyl transferase, PptA, is a novel antifungal target that directs secondary metabolite, siderophore, and lysine biosynthesis in Aspergillus fumigatus and is critical for pathogenicity. MBio 8(4), e01504-e01516.
(2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882.
(2016) Gliotoxin- bane or boon? Environ Microbiol 18(4), 1096-1109. (Review)
(2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), pii: e01439-14.
(2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600.
(2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi-parameter characterization of specific conventional and regulatory CD4+ T cells. Journal of Immunology 197(7), 3332-3343.
(2014) Opposed Effects of Enzymatic Gliotoxin N-and S-Methylations J.Am.Chem.Soc. (136), 11674-11679.
(2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8), 2221-2224.
(2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679.
(2014) Human and plant fungal pathogens: the role of secondary metabolites. PLOS Pathog 10(1), e1003859. (Review)
(2013) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide Soft Matter 3(9), 715-726.
(2013) Star-shaped drug carriers for doxorubicin with POEGMA and POEtOxMA brush-like shells: a structural, physical, and biological comparison. Biomacromolecules 14(8), 2536-2548.
(2013) Engineering fungal secondary metabolism: a roadmap to novel compounds. J Biotechnol 163(2), 179-183. (Review)
(2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095.
(2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10), 1757-1768.
(2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068.
(2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472.
(2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325.
(2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29), 10136-10141.
(2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4), 1098-1113.
(2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70(15-16), 1801-1811.
(2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70(2), 445-461.