
Prof. Dr. Christine Skerka
Infection Biology
Phone: +49 3641 532-1164 Fax: +49 3641 532-2164 Email: christine.skerka@leibniz-hki.de
(2020) A genome-wide association study identifies key modulators of complement factor h binding to malondialdehyde-epitopes. Proc Nat Acad Sci USA 117(18), 9942-9951. Details PubMed Open Access PDF
(2020) Long-term data on two sisters with C3GN due to an identical, homozygous CFH mutation and autoantibodies. Clini Nephrol 94(4), 197-206. Details PubMed
(2020) Immune modulation by complement receptor 3-dependent human monocyte TGF-ß1-transporting vesicles. Nat Commun 11(1), 2331. Details PubMed Open Access PDF
(2020) In situ visualization o C3/C5 convertases to differentiate complement activation. Kidney Int Rep 5(6), 927-930. Details PubMed Open Access PDF
(2020) Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparum. Eur J Immunol [In press] Details PubMed
(2020) Factor H-related protein 1: A complement protein and guardian of necrotic type surfaces. Br J Pharmacol [In press] Details PubMed
(2020) CFHR gene variations provide insights in the pathogenesis of the kidney diseases atypical hemolytic uremic syndrome and C3 glomerulopathy. J Am Soc Nephrol 31(2), 241-256. Details PubMed
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Front Immunol 10, 2573. Details PubMed Open Access PDF
(2019) Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. Nat Commun 10(1), 2961. Details PubMed Open Access PDF
(2019) Molecular crypsis by pathogenic fungi using human factor H. PLOS One 14(2), e0212187. Details PubMed Open Access PDF
(2019) Monitoring surface reactions by combined western blot-ELISA analysis. Methods Mol Biol 1834, 75-83. Details PubMed
(2019) ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25(3), 496-506. Details PubMed Open Access PDF
(2019) C3-glomerulopathy autoantibodies mediate distinct effects on complement C3- and C5-convertases. Front Immunol 10, 1030. Details PubMed Open Access PDF
(2019) Complement inhibitors in clinical trials for glomerular diseases. Front Immunol 10, 2166. Details PubMed Open Access PDF
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement
(2018) Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. J R Soc Interface 15(142), 20170963. Details PubMed Open Access
(2018) Kallikrein cleaves C3 and activates complement. J Innate Immun 10(2), 94-105. Details PubMed Open Access
(2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277. Details PubMed
(2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed Open Access
(2018) The MFHR1 fusion protein is a novel synthetic multitarget complement inhibitor with therapeutic potential. J Am Soc Nephrol 29(4), 1141-1153. Details PubMed Open Access
(2018) Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS One 13(8), e0200739. Details PubMed Open Access PDF
(2018) FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. J Immunol 201(12), 3497-3502. Details PubMed Open Access PDF
(2018) FHR5 binds to laminins, uses separate C3b and surface-binding sites, and activates complement on malondialdehyde-acetaldehyde surfaces. J Immunol 200(7), 2280-2290. Details PubMed Open Access PDF
(2018) Reply to kang and brooks: Comment on the interpretation of binding of Pra1, the fungal immune evasion protein from Candida albicans to the human C3 and on the conformational changes of C3 upon activation: Kang and brooks optimization of biolayer-interfero. Mol Immunol 101, 638-639. Details PubMed
(2017) Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium. Front Immunol 8, 703. Details PubMed
(2017) Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans. Front Immunol 7, 671. Details PubMed
(2017) Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina. EMBO Mol Med 9(2), 154-166. Details PubMed
(2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7, 40599. Details PubMed
(2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4. Details PubMed
(2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629. Details PubMed
(2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425. Details PubMed
(2016) Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. PLOS ONE 11(1), e0147709. Details PubMed
(2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Immunol 99, 407-424. Details PubMed
(2016) The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cell Microbiol 18(4), 573-590. Details PubMed
(2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Front Immunol 7, 542. Details PubMed
(2015) Host-pathogen interactions between the human innate immune system and Candida albicans - Understanding and modeling defense and evasion strategies Front Microbiol 6, 625. Details PubMed
(2015) Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch 467(10), 2179-2191. Details PubMed
(2015) Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack. PLOS One 10(9), e0137630. Details PubMed
(2015) Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical candida albicans isolates PLOS One 10(2), e0113192. Details PubMed
(2015) Atypical aHUS: State of the art. Mol Immunol 67(1), 31-42. Details PubMed
(2015) Complement the alternative Pathway Encyclopedia of Life Sciences; John Wiley & Sons, Ltd, Chichester [In press] Details
(2015) The role of complement in C3 glomerulopathy. Mol Immunol 67(1), 21-30. Details PubMed
(2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155. Details PubMed
(2014) Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes. Infect Immun 82(1), 380-392. Details PubMed
(2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally. Details PubMed Open Access
(2014) Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. PLOS One 9(3), e90796. Details PubMed
(2014) New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol 62(1), 235-248. Details PubMed
(2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed
(2014) A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. PLOS One 9(5), e96371. Details PubMed
(2014) Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. Mol Immunol 58(1), 77-84. Details PubMed
(2014) Standardisation of the factor H autoantibody assay. Immunobiology 219(1), 9-16. Details PubMed
(2014) Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. Ophthalmic Res 51(2), 59-66. Details PubMed
(2014) Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways. Int J Med Microbiol 304(2), 188-194. Details PubMed
(2013) Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet 22(23), 4857-4869. Details PubMed
(2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617. Details PubMed
(2013) CspA from Borrelia burgdorferi inhibits the terminal complement pathway. MBio 4(4), Details PubMed
(2013) BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem 288(35), 25229-25243. Details PubMed
(2013) Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24(1), 53-65. Details PubMed
(2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. J Infect Dis 207(4), 594-603. Details PubMed
(2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169. Details PubMed
(2013) Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. PLOS One 8(1), e53659. Details PubMed
(2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13(1), 29-41. Details PubMed
(2013) Complement factor H related proteins (CFHRs). Mol Immunol 56(3), 170-180. Details PubMed
(2013) 14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013. Mol Immunol 56(3), 151-151. Details PubMed
(2012) Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. J Immunol 189(10), 4939-4950. Details PubMed
(2012) Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol 2012, 349657. Details PubMed
(2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed
(2011) Combined C3b and factor B autoantibodies and MPGN type II. N Engl J Med 365(24), 2340-2342. Details PubMed
(2011) β₂-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator. Blood 118(10), 2774-2783. Details PubMed
(2011) Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. J Immunol 187(8), 4374-4383. Details PubMed
(2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed
(2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478(7367), 76-81. Details PubMed
(2011) Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol 301(5), 423-430. Details PubMed
(2011) Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura? Pediatr Nephrol 26(11), 1947-1956. Details PubMed
(2010) Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. PLOS One 5(10), e13519. Details PubMed
(2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475. Details PubMed