Christine Skerka

Prof. Dr. Christine Skerka

Infection Biology

Phone: +49 3641 532-1164 Fax: +49 3641 532-2164 Email: christine.skerka@leibniz-hki.de

Topics
Publications

Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdaukas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C (2019) Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. Nat Commun 10(1), 2961. Details PubMed

Lang SN, Germerodt S, Glock C, Skerka C, Zipfel PF, Schuster S (2019) Molecular crypsis by pathogenic fungi using human factor H. PLoS One 14(2), e0212187. Details PubMed

Lin Y, Irmscher S, Skerka C (2019) Monitoring Surface Reactions by Combined Western Blot-ELISA Analysis. Methods Mol Biol 1834, 75-83. Details PubMed

Yin C, Ackermann S, Ma Z, Mohanta SK, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Markus Hildner M, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR (2019) ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med 25(3), 496-506. Details PubMed

Zhao F, Afonso S, Lindner S, Hartmann A, Löschmann I, Nilsson B, Ekdahl KN, Weber LT, Habbig S, Schalk G, Kirschfink M, Zipfel PF, Skerka C (2019) C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases. Front Immunol 10, 1030. Details PubMed

Zipfel PF, Dasari P, Koleci N, Shopova I, Wartenberg D, Beyersdorf N, Dietrich S, Sahagun-Ruiz A, Figge MT, Skerka C, Brakhage AA (2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein. Frontiers in Immunology [Accepted] Details

Zipfel PF, Wiech T, Rudnick R, Afonso S, Person F, Skerka C (2019) Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol 10, 2166. Details PubMed Open Access PDF

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement

Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C (2018) Kallikrein cleaves C3 and activates complement. J Innate Immun 10(2), 94-105. Details PubMed

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277. Details PubMed

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed

Michelfelder S, Fischer F, Wäldin A, Hörle K, Pohl M, Parsons J, Reski R, Decker EL, Zipfel PF, Skerka C, Häffner K (2018) The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential. J Am Soc Nephrol 29(4), 1141-1153. Details PubMed

Pujol-Lereis LM, Liebisch G, Schick T, Lin Y, Grassmann F, Uchida K, Zipfel PF, Fauser S, Skerka C, Weber BHF (2018) Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS One 13(8), e0200739. Details PubMed

Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G (2018) FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. J Immunol 201(12), 3497-3502. Details PubMed

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF (2018) FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. J Immunol 200(7), 2280-2290. Details PubMed

Busch C, Annamalai B, Abdusalamova K, Reichhart N, Huber C, Lin Y, JAH, Zipfel PF, Skerka C, Wildner G, Diedrichs-Möhring M, Rohrer B, Strauß O (2017) Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium. Front Immunol 8, 703. Details PubMed

Halder LD, Abdelfatah MA, Jo EA, Jacobsen ID, Westermann M, Beyersdorf N, Lorkowski S, Zipfel PF, Skerka C (2017) Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans. Front Immunol 7, 671. Details PubMed

Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H (2017) Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina. EMBO Mol Med 9(2), 154-166. Details PubMed

Klassert TE, Bräuer J, Hölzer M, Riege K, Stock M, Zubiría-Barrera C, Skerka C, Müller MM, Rummler S, Marz M, Slevogt H (2017) Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection. Sci Rep 7, 40599. Details PubMed

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4. Details PubMed

Buhlmann D*, Eberhardt HU*, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C *authors contributed equally (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629. Details PubMed

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF (2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425. Details PubMed

Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K (2016) Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. PLOS ONE 11(1), e0147709. Details PubMed

Hammerschmidt H, Klevenhaus Y, Koenigs A, Hallström T, Fingerle V, Skerka C, Pos KM, Zipfel PF, Wallich R, Kraiczy P (2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Immunol 99, 407-424. Details PubMed

Rosa TF, Flammersfeld A, Ngwa CJ, Kiesow M, Fischer R, Zipfel PF, Skerka C, Pradel G (2016) The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement. Cell Microbiol 18(4), 573-590. Details PubMed

Schäfer N, Grosche A, Reinders J, Hauck SM, Pouw RB, Kuijpers TW, Wouters D, Ehrenstein B, Enzmann V, Zipfel PF, Skerka C, Pauly D (2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Front Immunol 7, 542. Details PubMed

Duehring S, Germerodt S, Skerka C, Zipfel PF, Dandekar T, Schuster S (2015) Host-pathogen interactions between the human innate immune system and Candida albicans - Understanding and modeling defense and evasion strategies Front Microbiol 6, 625. Details PubMed

Genewsky A, Jost I, Busch C, Huber C, Stindl J, Skerka C, Zipfel PF, Rohrer B, Strauß O (2015) Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium. Pflugers Arch 467(10), 2179-2191. Details PubMed

Hallström T, Uhde M, Singh B, Skerka C, Riesbeck K, Zipfel PF (2015) Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack. PLOS One 10(9), e0137630. Details PubMed

Luo S, Hipler UC, Münzberg C, Skerka C, Zipfel PF (2015) Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical candida albicans isolates PLOS One 10(2), e0113192. Details PubMed

Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ (2015) Atypical aHUS: State of the art. Mol Immunol 67(1), 31-42. Details PubMed

Zipfel PF, Skerka C (2015) Complement the alternative Pathway Encyclopedia of Life Sciences; John Wiley & Sons, Ltd, Chichester [In press] Details

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, Córdoba SR, Noris M, Pickering M, Smith R (2015) The role of complement in C3 glomerulopathy. Mol Immunol 67(1), 21-30. Details PubMed

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124(1), 145-155. Details PubMed

Hammerschmidt C, Koenigs A, Siegel C, Hallström T, Skerka C, Wallich R, Zipfel PF, Kraiczy P (2014) Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes. Infect Immun 82(1), 380-392. Details PubMed

Kraibooj K*, Park HR*, Dahse HM, Skerka C, Voigt K⁺, Figge MT⁺ (2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally. Details PubMed Open Access

Lopez CM, Wallich R, Riesbeck K, Skerka C, Zipfel PF (2014) Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin. PLOS One 9(3), e90796. Details PubMed

Mehta G, Ferreira VP, Skerka C, Zipfel PF, Banda NK (2014) New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol 62(1), 235-248. Details PubMed

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed

Pauly D, Nagel BM, Reinders J, Killian T, Wulf M, Ackermann S, Ehrenstein B, Zipfel PF, Skerka C, Weber BH (2014) A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. PLOS One 9(5), e96371. Details PubMed

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R (2014) Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. Mol Immunol 58(1), 77-84. Details PubMed

Watson R, Lindner S, Bordereau P, Hunze EM, Tak F, Ngo S, Zipfel PF, Skerka C, Dragon-Durey MA, Marchbank KJ (2014) Standardisation of the factor H autoantibody assay. Immunobiology 219(1), 9-16. Details PubMed

Weinberger AW, Eddahabi C, Carstesen D, Zipfel PF, Walter P, Skerka C (2014) Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells. Ophthalmic Res 51(2), 59-66. Details PubMed

Zipfel PF, Skerka C (2014) Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways. Int J Med Microbiol 304(2), 188-194. Details PubMed

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF (2013) Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration. Hum Mol Genet 22(23), 4857-4869. Details PubMed

Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C (2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617. Details PubMed

Hallström T, Siegel C, Mörgelin M, Kraiczy P, Skerka C, Zipfel PF (2013) CspA from Borrelia burgdorferi inhibits the terminal complement pathway. MBio 4(4), Details PubMed

Koenigs A, Hammerschmidt C, Jutras BL, Pogoryelov D, Barthel D, Skerka C, Kugelstadt D, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2013) BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein. J Biol Chem 288(35), 25229-25243. Details PubMed

Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC (2013) Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis. J Am Soc Nephrol 24(1), 53-65. Details PubMed

Luo S, Hoffmann R, Skerka C, Zipfel PF (2013) Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans. J Infect Dis 207(4), 594-603. Details PubMed

Luo S, Skerka C, Kurzai O, Zipfel PF (2013) Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 56(3), 161-169. Details PubMed

Schwab J, Hammerschmidt C, Richter D, Skerka C, Matuschka FR, Wallich R, Zipfel PF, Kraiczy P (2013) Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. PLOS One 8(1), e53659. Details PubMed

Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G (2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13(1), 29-41. Details PubMed

Skerka C, Chen Q, Fremeaux-Bacchi V, Roumenina LT (2013) Complement factor H related proteins (CFHRs). Mol Immunol 56(3), 170-180. Details PubMed

Zipfel PF, Skerka C, Hallström T, Wolf G (2013) 14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013. Mol Immunol 56(3), 151-151. Details PubMed

Hallström T, Mörgelin M, Barthel D, Raguse M, Kunert A, Hoffmann R, Skerka C, Zipfel PF (2012) Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen. J Immunol 189(10), 4939-4950. Details PubMed

Hammerschmidt C, Hallström T, Skerka C, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2012) Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi. Clin Dev Immunol 2012, 349657. Details PubMed

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Chen Q, Müller D, Rudolph B, Hartmann A, Kuwertz-Bröking E, Wu K, Kirschfink M, Skerka C, Zipfel PF (2011) Combined C3b and factor B autoantibodies and MPGN type II. N Engl J Med 365(24), 2340-2342. Details PubMed

Gropp K, Weber N, Reuter M, Micklisch S, Kopka I, Hallström T, Skerka C (2011) β₂-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator. Blood 118(10), 2774-2783. Details PubMed

Lauer N, Mihlan M, Hartmann A, Schlötzer-Schrehardt U, Keilhauer C, Scholl HP, Charbel Issa P, Holz F, Weber BH, Skerka C, Zipfel PF (2011) Complement regulation at necrotic cell lesions is impaired by the age-related macular degeneration-associated factor-H His402 risk variant. J Immunol 187(8), 4374-4383. Details PubMed

Luo S, Blom AM, Rupp S, Hipler UC, Hube B, Skerka C, Zipfel PF (2011) The pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion. J Biol Chem 286(10), 8021-8029. Details PubMed

Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ (2011) Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature 478(7367), 76-81. Details PubMed

Zipfel PF, Skerka C, Kupka D, Luo S (2011) Immune escape of the human facultative pathogenic yeast Candida albicans: the many faces of the Candida Pra1 protein. Int J Med Microbiol 301(5), 423-430. Details PubMed

Zipfel PF, Wolf G, John U, Kentouche K, Skerka C (2011) Novel developments in thrombotic microangiopathies: is there a common link between hemolytic uremic syndrome and thrombotic thrombocytic purpura? Pediatr Nephrol 26(11), 1947-1956. Details PubMed

Siegel C, Hallström T, Skerka C, Eberhardt H, Uzonyi B, Beckhaus T, Karas M, Wallich R, Stevenson B, Zipfel PF, Kraiczy P (2010) Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. PLOS One 5(10), e13519. Details PubMed

Gropp K, Schild L, Schindler S, Hube B, Zipfel PF, Skerka C (2009) The yeast Candida albicans evades human complement attack by secretion of aspartic proteases. Mol Immunol 47(2-3), 465-475. Details PubMed