Christian Hertweck

Prof. Dr. Christian Hertweck

Biomolecular Chemistry · Head Directorate · Deputy Director

Phone: +49 3641 532-1101 Fax: +49 3641 532-0804 Email: christian.hertweck@leibniz-hki.de

Main Research Areas
  • Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
  • Use of enzymes and recombinant microorganisms for synthetic implementation
  • Isolation and structural identification of natural products
  • Molecular basis of fungus-bacteria-interactions
Curriculum vitae

Professional Career

2011 Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland
Since 2008 Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany
2008 Rejection of professorship, Technical University Munich, Germany
Since 2006 Head of Department of Biomolecular Chemistry, HKI Jena
Since 2006 Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany
2006 Habilitation (Venia legendi) in organic chemistry, FSU Jena
2005 Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany
2005 Acceptance of professorship (W3), FSU Jena
2001 - 2005 Head of junior research group, HKI Jena
1999 - 2000 Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation)
1996 - 1999 PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship
1996 Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany

Awards · Appointments · Scientific Activities

2015 Member of the National Academy of Sciences Leopoldina
2015 Gottfried Wilhelm Leibniz Award
2015 David Gottlieb Memorial Lecture Award, University of Illinois
2014 Wilhelm Manchot-Research Professor
Since 2013 Member of the editorial board Bioorganic Chemistry
Since 2012 Editor, Chemistry & Biology
Since 2012 Member of the faculty of 1000
Since 2011 Member of the editorial board, Organic and Biomolecular Chemistry
Since 2011 Member of the editorial board, Journal of Antibiotics
2011 NPR lecture award
Since 2010 Member of the editorial board, ChemBioChem
2009 - 2012 Member of the editorial board, Chemistry & Biology
2006 Research prize of the Dr. Otto Röhm-Memorial-Foundation
Since 2005 Member of the Association for General and Applied Microbiology (VAAM)
2005 DECHEMA award for natural product research
2005 Science award for life sciences and physics from the Beutenberg Campus Jena e.V.
2005 Thuringian research award (category: basic research)
Since 2003 Member of the programme committee, Natural Product Meeting, Irsee
Since 2002 Member of the DECHEMA Society for Chemical Engineering and Biotechnology
Since 2001 Member of the Gesellschaft Deutscher Chemiker (GDCh)
Publications

Dose B, Niehs SP, Scherlach K, Flórez LV, Kaltenpoth M, Hertweck C (2018) Unexpected Bacterial Origin of the Antibiotic Icosalide: Two-Tailed Depsipeptide Assembly in Multifarious Burkholderia Symbionts. ACS Chem Biol 13(9), 2414-2420. Details PubMed

Dunbar KL, Büttner H, Molloy EM, Dell M, Kumpfmüller J, Hertweck C (2018) Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria. Angew Chem Int Ed 57(43), 14080-14084. Details PubMed

Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthewse A, Scherlach K, Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon, Krespach MK, Shelest E, Schroeckh V, Valiante V, Heinzel T, Hertweck C, Strauss J, Brakhage AA (2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites eLife [Epub ahead of print] Details PubMed

Flórez LV, Scherlach K, Miller IJ, Rodrigues A, Kwan JC, Hertweck C, Kaltenpoth M (2018) An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles. Nat Commun 9(1), 2478. Details PubMed

Heimerl N, Hommel E, Westermann M, Meichsner D, Lohr M, Hertweck C, Grossman AR, Mittag M, Sasso S (2018) A giant type I polyketide synthase participates in zygospore maturation in Chlamydomonas reinhardtii. Plant J 95(2), 268-281. Details PubMed

Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B (2018) Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nat Commun 9(1), 2208. Details PubMed

Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C (2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14(9), 841-843. Details PubMed

Kloss F, Neuwirth T, Haensch VG, Hertweck C (2018) Metal-Free Synthesis of Pharmaceutically Important Biaryls by Photosplicing. Angew Chem Int Ed 57(44), 14476-14481. Details PubMed

König S, Pace S, Pein H, Heinekamp T, Kramer J, Romp E, Straßburger M, Troisi F, Proschak A, Dworschak J, Scherlach K, Rossi A, Sautebin L, Haeggström JZ, Hertweck C, Brakhage AA, Gerstmeier J, Proschak E, Werz O (2018) Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolase Cell Chem Biol. [Accepted] Details

Litomska A, Ishida K, Dunbar KL, Boettger M, Coyne S, Hertweck C (2018) Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway. Angew Chem Int Ed 57(36), 11574-11578. Details PubMed

Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M (2018) Detection of antibiotics synthetized in microfluidic picoliter-droplets by varios actinobacteria Sci Rep 8(1), 13087. Details PubMed Open Access

Mahler L, Wink K, Beulig RJ, Scherlach K, Tovar M, Zang E, Martin K, Hertweck C, Belder D, Roth M (2018) Publisher Correction: Detection of antibiotics synthetized in microfluidic picolitre-droplets by various actinobacteria. Sci Rep 8(1), 15859. Details PubMed Open Access

Niehs S, Dose B, Scherlach K, Roth M, Hertweck C (2018) Genomics-Driven Discovery of a Symbiont-Specific Cyclopeptide from Bacteria Residing in the Rice Seedling Blight Fungus. ChemBioChem 19(20), 2167-2172. Details PubMed

Niehs SP, Scherlach K, Hertweck C (2018) Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria. Org Biomol Chem 16(37), 8345-8352. Details PubMed

Scharf DH, Dworschak JD, Chankhamjon P, Scherlach K, Heinekamp T, Brakhage AA, Hertweck C (2018) Reconstitution of Enzymatic Carbon-Sulfur Bond Formation Reveals Detoxification-Like Strategy in Fungal Toxin Biosynthesis. ACS Chem Biol 13(9), 2508-2512. Details PubMed

Scherlach K, Hertweck C (2018) Mediators of mutualistic microbe-microbe interactions. Nat Prod Rep 35(4), 303-308. (Review) Details PubMed

Sundaram S, Kim HJ, Bauer R, Thongkongkaew T, Heine D, Hertweck C (2018) On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain. Angew Chem Int Ed 57(35), 11223-11227. Details PubMed

Thongkongkaew T, Ding W, Bratovanov E, Oueis E, Garcia-Altares M, Zaburannyi N, Harmrolfs K, Zhang Y, Scherlach K, Müller R, Hertweck C (2018) Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species. ACS Chem Biol 13(5), 1370-1379. Details PubMed

Trottmann F, Franke J, Ishida K, Garcia-Altares M, Hertweck C (2018) A pair of bacterial siderophores releases and traps an intercellular signal molecule: An unusual case of natural nitrone bioconjugation. Angew Chem Int Ed Engl , Details PubMed

Tsunematsu Y, Maeda N, Yokoyama M, Chankhamjon P, Watanabe K, Scherlach K, Hertweck C (2018) Enzymatic Amide Tailoring Expedites Unusual Retro-Aldol-Type Amino Acid Conversion to Form Antifungal Cyclopeptide. Angew Chem Int Ed 57(43), 14051-14054. Details PubMed

Aiyar P, Schaeme D, García-Altares M, Carrasco Flores D, Dathe H, Hertweck C, Sasso S, Mittag M (2017) Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nat Commun 8(1), 1756. Details PubMed

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D (2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol , Details PubMed

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D (2017) (2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol [Accepted] Details

Brandt P, García-Altares M, Nett M, Hertweck C, Hoffmeister D (2017) Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase. Angew Chem Int Ed 56(21), 5937-5941. Details PubMed

Dunbar KL, Scharf DH, Litomska A, Hertweck C (2017) Enzymatic Carbon-Sulfur Bond Formation in Natural Product Biosynthesis. Chem Rev 117(8), 5521-5577. (Review) Details PubMed

Flórez LV, Scherlach K, Gaube P, Ross C, Sitte E, Hermes C, Rodrigues A, Hertweck C, Kaltenpoth M (2017) Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism. Nat Commun 8, 15172. Details PubMed

Guljamow A, Kreische M, Ishida K, Liaimer A, Altermark B, Bähr L, Hertweck C, Ehwald R, Dittmann E (2017) High-density cultivation of terrestrial Nostoc strains leads to reprogramming of secondary metabolome. Appl Environ Microbiol , Details PubMed

Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM (2017) Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ. ACS Chem Biol 12(7), 1874-1882. Details PubMed

Molloy EM, Hertweck C (2017) Antimicrobial discovery inspired by ecological interactions. Curr Opin Microbiol 39, 121-127. Details PubMed

Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID (2017) A functional link between hyphal maintenance and quorum sensing in Candida albicans. Mol Microbiol 103(4), 595-617. Details PubMed

Shao Y, Chen B, Sun C, Ishida K, Hertweck C, Boland W (2017) Symbiont-Derived Antimicrobials Contribute to the Control of the Lepidopteran Gut Microbiota. Cell Chem Biol 24(1), 66-75. Details PubMed

Valiante V, Mattern DJ, Schüffler A, Horn F, Walther G, Scherlach K, Petzke L, Dickhaut J, Guthke R, Hertweck C, Nett M, Thines E, Brakhage AA (2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement

Barnes EC, Jumpathong J, Lumyong S, Voigt K, Hertweck C (2016) Daldionin, an unprecedented binaphthyl derivative, and diverse polyketide congeners from a fungal orchid endophyte. Chemistry 22(13), 4551-4555. Details PubMed

Chankhamjon P, Tsunematsu Y, Ishida-Ito M, Sasa Y, Meyer F, Boettger-Schmidt D, Urbansky B, Menzel KD, Scherlach K, Watanabe K, Hertweck C (2016) Regioselective Dichlorination of a Non-Activated Aliphatic Carbon Atom and Phenolic Bismethylation by a Multifunctional Fungal Flavoenzyme. Angew Chem Int Ed 55(39), 11955-11959. Details PubMed

De Felice A, Di Lorenzo F, Scherlach K, Ross C, Silipo A, Hertweck C, Molinaro A (2016) Structural investigation of the lipopolysaccharide O-chain isolated from Burkholderia fungorum strain DSM 17061. Carbohydr Res 433, 31-35. Details PubMed

De Felice A, Silipo A, Scherlach K, Ross C, Hertweck C, Molinaro A (2016) Structural and conformational study of the O‐antigenic portion of the Lipopolysaccharide isolated from Burkholderia gladioli pv. cocovenenans. Eur J Org Chem 4, 748-755. Details

Dolatabadi S, Scherlach K, Figge M, Hertweck C, Dijksterhuis J, Menken SB, de Hoog GS (2016) Food preparation with mucoralean fungi: A potential biosafety issue? Fungal Biol 120(3), 393-401. Details PubMed

Franke J, Hertweck C (2016) Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges. Cell Chem Biol 23(10), 1179-1192. (Review) Details PubMed

Geib E, Gressler M, Viediernikova I, Hillmann F, Jacobsen ID, Nietzsche S, Hertweck C, Brock M (2016) A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress. Cell Chem Biol 23(5), 587-597. Details PubMed

Guo H, Kreuzenbeck NB, Otani S, Garcia-Altares M, Dahse HM, Weigel C, Aanen DK, Hertweck C, Poulsen M, Beemelmanns C (2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed

Heine D, Sundaram S, Beudert M, Martin K, Hertweck C (2016) A widespread bacterial phenazine forms conjugates with biogenic thiols and crosslinks proteins. Chem Sci 7, 4848-4855. Details PDF

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H (2016) Cell Chemical Biology: Home of Exciting Chemical Biology. Cell Chem Biol 23(1), 1-2. (Review) Details

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H (2016) Voices of Chemical Biology: Charting the Next Decade. Cell Chem Biol 23(2), 199. (Review) Details Open Access

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H (2016) Our Advisors, Our Ambassadors, Our Editorial Board Members. Cell Chem Biol 23(3), 311-312. (Review) Details PubMed

Kostic M, Crews CM, Hertweck C, Shokat K, Suga H. (2016) From Powerful Review Articles to Research Breakthroughs Cell Chem Biol 2016 Aug 18(23(8)), 883-884. (Review) Details

Sun Y, Meng Z, Chen P, Zhang D, Baunach M, Hertweck C, Li A (2016) A concise total synthesis of sespenine, a structurally unusual indole terpenoid from Streptomyces. Org Chem Front 3, 368-374. Details PDF Supplement

Sundaram S, Hertweck C (2016) On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems. Curr Opin Chem Biol 31, 82-94. (Review) Details PubMed

Ueberschaar N, Heine D, Hertweck C (2016) Zinc(II)-Assisted Aryl-Finkelstein-Reaction for the Synthesis of Aryl Iodides. Synlett 27, 1794-1797. Details Open Access

Ueberschaar N, Meyer F, Dahse HM, Hertweck C (2016) Bipiperidine conjugates as soluble sugar surrogates in DNA-intercalating antiproliferative polyketides. Chem Commun (Camb) 52(27), 4894-4897. Details PubMed

Walther E, Boldt S, Kage H, Lauterbach T, Martin K, Roth M, Hertweck C, Sauerbrei A, Schmidtke M, Nett M (2016) Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties GMS Infect Dis 4, Doc08. Details Open Access

Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D (2016) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204. Details PubMed Open Access

Barnes EC, Bezerra-Gomes P, Nett M, Hertweck C (2015) Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus. J Antibiot (Tokyo) 68, 463-468. Details PubMed

Baunach M, Ding L, Willing K, Hertweck C (2015) Bacterial synthesis of unusual sulfonamide and sulfone antibiotics by flavoenzyme-mediated sulfur dioxide capture. Angew Chem Int Ed Engl. 54(45), 13279-13283. Details PubMed

Baunach M, Franke J, Hertweck C (2015) Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis. Angew. Chem. Int. Ed. 54(9), 2604-2626. Details PubMed

Baunach M, Hertweck C (2015) Natural 1,3-Dipolar Cycloadditions. Angew Chem Int Ed Engl. 54(43), 12550-12552. (Review) Details PubMed

Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D (2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutus. Chem Biol 22, 1325-1334. Details PubMed

Chiriac AI, Kloss F, Krämer J, Vuong C, Hertweck C, Sahl HG (2015) Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors. J Antimicrob Chemother 70(9), 2576-2588. Details PubMed

Ding L, Franke J, Hertweck C (2015) Divergolide congeners illuminate alternative reaction channels for ansamycin diversification. Org. Biomol. Chem. 13(6), 1618-1623. Details PubMed

Ding L, Goerls H, Dornblut K, Lin W, Maier A, Fiebig HH, Hertweck C (2015) Bacaryolanes A-C, rare bacterial caryolanes from a mangrove endophyte. J Nat Prod. 78(12), 2963-2967. Details PubMed Open Access PDF

Franke J, Ishida K, Hertweck C (2015) Plasticity of the Malleobactin Pathway and its Impact on Siderophore Action in Human Pathogenic Bacteria. Chemistry 21(22), 8010-8014. Details PubMed

Graupner K, Lackner G, Hertweck C (2015) Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announc. 3(2), pii: e00277-15. Details PubMed Open Access

Gressler M, Meyer F, Heine D, Hortschansky P, Hertweck C, Brock M (2015) Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife 4, e07861. Details PubMed Open Access PDF

Heine D, Sundaram S, Bretschneider T, Hertweck C (2015) Twofold polyketide branching by a stereoselective enzymatic Michael addition Chem Commun (Camb). 51(48), 9872-9875. Details PubMed

Hertweck C (2015) Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology. Trends Biochem Sci. 40(4), 189-199. (Review) Details PubMed

Hertweck C (2015) Natural Products as Source of Therapeutics against Parasitic Diseases. Angew Chem Int Ed Engl. 54(49), 14622-14624. (Review) Details PubMed

Horn F, Habel A, Scharf DH, Dworschak J, Brakhage AA, Guthke R, Hertweck C, Linde J (2015) Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus Verticillium hemipterigenum. Genome Announc 3(1), pii: e01439-14. Details PubMed Open Access

Horn F, Üzüm Z, Möbius N, Guthke R, Linde J, Hertweck C (2015) Draft Genome Sequences of Symbiotic and Nonsymbiotic Rhizopus microsporus Strains CBS 344.29 and ATCC 62417. Genome Announc 3(1), pii: e01370-14. Details PubMed Open Access

Leonhardt I, Spielberg S, Weber M, Albrecht-Eckardt D, Bläss M, Claus R, Barz D, Scherlach K, Hertweck C, Löffler J, Hünniger K, Kurzai O (2015) The fungal quorum-sensing molecule farnesol activates innate immune cells but suppresses cellular adaptive immunity. MBio 6(2), e00143. Details PubMed

Liaimer A, Helfrich EJ, Hinrichs K, Guljamow A, Ishida K, Hertweck C, Dittmann E (2015) Nostopeptolide plays a governing role during cellular differentiation of the symbiotic cyanobacterium Nostoc punctiforme. Proc Natl Acad Sci U S A 112(6), 1862-1867. Details PubMed

Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of cAMP-dependent protein kinase A regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus Mol Microbiol 96(1), 148-162. Details PubMed

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details

Shabuer G, Ishida K, Pidot SJ, Roth M, Dahse HM, Hertweck C (2015) Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory. Science 350(6261), 670-674. Details PubMed

Sugimoto Y, Ishida K, Traitcheva N, Busch B, Dahse HM, Hertweck C (2015) Freedom and constraint in engineered noncolinear polyketide assembly lines Chem Biol 22(2), 229-240. Details PubMed

Sundaram S, Heine D, Hertweck C (2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching Nat Chem Biol. 11(12), 949-951. Details PubMed

Uzum Z, Silipo A, Lackner G, De Felice A, Molinaro A, Hertweck C (2015) Structure, Genetics and Function of an Exopolysaccharide Produced by a Bacterium Living within Fungal Hyphae. Chembiochem 16(3), 387-392. Details PubMed

Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle TF, Stehle T (2015) Structural basis of head to head polyketide fusion by CorB. Chem Sci 6(11), 6525-6536. Details

Cai X, Ng K, Panesar H, Moon SJ, Paredes M, Ishida K, Hertweck C, Minehan TG (2014) Total synthesis of the antitumor natural product polycarcin V and evaluation of its DNA binding profile. Org Lett 16(11), 2962-2965. Details PubMed

Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. Details PubMed

Coyne S, Litomska A, Chizzali C, Khalil MN, Richter K, Beerhues L, Hertweck C (2014) Control of plant defense mechanisms and fire blight pathogenesis through the regulation of 6-thioguanine biosynthesis in Erwinia amylovora. Chembiochem 15(3), 373-376. Details PubMed

Crews C, Hertweck C, Shokat K, Suga H, Kostic M (2014) Reflecting on the past and looking forward to the future of bridging chemistry and biology. Chem Biol 21(9), 1035-1036. Details PubMed

Franke J, Ishida K, Hertweck C (2014) Evolution of siderophore pathways in human pathogenic bacteria. J Am Chem Soc 136(15), 5599-5602. Details PubMed

Gatte-Picchi D, Weiz A, Ishida K, Hertweck C, Dittmann E (2014) Functional analysis of environmental DNA-derived microviridins provides new insights into the diversity of the tricyclic peptide family. Appl Environ Microbiol 80(4), 1380-1387. Details PubMed

Habel A, Scharf DH, Heinekamp T, Brakhage AA, Hertweck C (2014) Opposed Effects of Enzymatic Gliotoxin N-and S-Methylations J.Am.Chem.Soc. (136), 11674-11679. Details

Heine D, Bretschneider T, Sundaram S, Hertweck C (2014) Enzymatic Polyketide Chain Branching to Give Substituted Lactone, Lactam, and Glutarimide Heterocycles. Angew Chem Int Ed Engl 53(43), 11645-11649. Details PubMed

Heine D, Martin K, Hertweck C (2014) Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714. J Nat Prod 77(4), 1083-1087. Details PubMed

Jaschinski T, Helfrich EJ, Bock C, Wolfram S, Svatoš A, Hertweck C, Pohnert G (2014) Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana. J Mass Spectrom 49(2), 136-144. Details PubMed

Kloss F, Chiriac AI, Hertweck C (2014) Mapping of the modular closthioamide architecture reveals crucial motifs of polythioamide antibiotics. Chemistry 20(47), 15451-15458. Details PubMed

Letzel AC, Pidot SJ, Hertweck C (2014) Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria. BMC Genomics 15, 983. Details PubMed

Moebius N, Uzüm Z, Dijksterhuis J, Lackner G, Hertweck C (2014) Active invasion of bacteria into living fungal cells. Elife , e03007. Details PubMed

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF (2014) Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein. Mol Immunol 62(1), 249-264. Details PubMed

Pidot S, Ishida K, Cyrulies M, Hertweck C (2014) Discovery of clostrubin, an exceptional polyphenolic polyketide antibiotic from a strictly anaerobic bacterium. Angew Chem Int Ed Engl 53(30), 7856-7859. Details PubMed

Pidot SJ, Coyne S, Kloß F, Hertweck C (2014) Antibiotics from neglected bacterial sources. Int J Med Microbiol 304(1), 14-22. Details PubMed

Ross C, Opel V, Scherlach K, Hertweck C (2014) Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus. Mycoses 57, 48-55. Details PubMed

Ross C, Scherlach K, Kloss F, Hertweck C (2014) The molecular basis of conjugated polyyne biosynthesis in phytopathogenic bacteria. Angew Chem Int Ed Engl 53(30), 7794-7798. Details PubMed

Scharf DH, Groll M, Habel A, Heinekamp T, Hertweck C, Brakhage AA, Huber EM (2014) Flavoenzyme-catalyzed formation of disulfide bonds in natural products. Angew Chem Int Ed Engl 53(8), 2221-2224. Details PubMed

Scharf DH, Habel A, Heinekamp T, Brakhage AA, Hertweck C (2014) Opposed effects of enzymatic gliotoxin N- and S-methylations. J Am Chem Soc 136(33), 11674-11679. Details PubMed

Sugimoto Y, Ding L, Ishida K, Hertweck C (2014) Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angew Chem Int Ed Engl 53(6), 1560-1564. Details PubMed

Sun Y, Chen P, Zhang D, Baunach M, Hertweck C, Li A (2014) Bioinspired total synthesis of sespenine. Angew Chem Int Ed Engl 53(34), 9012-9016. Details PubMed

Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr JC, Müller KM, Groll M, Hertweck C, Dittmann E (2014) Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions. Angew Chem Int Ed Engl 53(14), 3735-3738. Details PubMed

Xu Z, Baunach M, Ding L, Peng H, Franke J, Hertweck C (2014) Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte. Chembiochem 15(9), 1274-1279. Details PubMed

Zaehle C, Gressler M, Shelest E, Geib E, Hertweck C, Brock M (2014) Terrein Biosynthesis in Aspergillus terreus and Its Impact on Phytotoxicity. Chem Biol 21(6), 719-731. Details PubMed

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA (2013) Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep 30(1), 108-160. Details PubMed

Baunach M, Ding L, Bruhn T, Bringmann G, Hertweck C (2013) Regiodivergent N-C and N-N aryl coupling reactions of indoloterpenes and cycloether formation mediated by a single bacterial flavoenzyme. Angew Chem Int Ed Engl 52(34), 9040-9043. Details PubMed

Boettger D, Hertweck C (2013) Molecular diversity sculpted by fungal PKS-NRPS hybrids. Chembiochem 14(1), 28-42. Details PubMed

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C (2013) Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Nature 502(7469), 124-128. Details PubMed

Coyne S, Chizzali C, Khalil MN, Litomska A, Richter K, Beerhues L, Hertweck C. (2013) Biosynthesis of the antimetabolite 6-thioguanine in Erwinia amylovora plays a key role in fire blight pathogenesis. Angew Chem Int Ed Engl. 52(40), 10564-10568. Details

Franke J, Ishida K, Ishida-Ito M, Hertweck C (2013) Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis. Angew Chem Int Ed Engl 52(32), 8271-8275. Details PubMed

Grumbt M, Monod M, Yamada T, Hertweck C, Kunert J, Staib P (2013) Keratin degradation by dermatophytes relies on cysteine dioxygenase and a sulfite efflux pump. J Invest Dermatol 133(6), 1550-1555. Details PubMed

Hennicke F, Grumbt M, Lermann U, Ueberschaar N, Palige K, Böttcher B, Jacobsen ID, Staib C, Morschhäuser J, Monod M, Hube B, Hertweck C, Staib P (2013) Factors supporting cysteine tolerance and sulfite production in Candida albicans. Eukaryot Cell 12(4), 604-613. Details PubMed

König CC, Scherlach K, Schroeckh V, Horn F, Nietzsche S, Brakhage AA, Hertweck C (2013) Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem 14(8), 938-942. Details PubMed

Letzel AC, Pidot SJ, Hertweck C (2013) A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat Prod Rep 30(3), 392-428. Details PubMed

Mayeku PW, Hassanali A, Kiremire BT, Odalo JO, Hertweck C (2013) Anti-bacterial activities and phytochemical screening of extracts of different parts of Thalictrum rhynchocarpum. Afr J Tradit Complement Altern Med 10(5), 341-344. Details PubMed

Meyer F, Ueberschaar N, Dahse HM, Hertweck C (2013) Synthesis and biological evaluation of hydrazidomycin analogues. Bioorg Med Chem Lett 23(22), 6043-6045. Details PubMed

Meyer F, Ueberschaar N, Hertweck C (2013) Concise Total Synthesis of Hydrazidomycin A, a Rare Hydrazide Metabolite of Streptomyces atratus Eur. J. Org. Chem , 4242-4244. Details

Nützmann HW, Fischer J, Scherlach K, Hertweck C, Brakhage AA (2013) Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans. Appl Environ Microbiol 79(19), 6102-6109. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Willing K, Brakhage AA, Hertweck C (2013) Epidithiodiketopiperazine biosynthesis: a four-enzyme cascade converts glutathione conjugates into transannular disulfide bridges. Angew Chem Int Ed Engl 52(42), 11092-11095. Details PubMed

Scherlach K, Graupner K, Hertweck C (2013) Molecular bacteria-fungi interactions: effects on environment, food, and medicine. Annu Rev Microbiol 67, 375-397. Details PubMed

Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C (2013) Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem 14(18), 2439-2443. Details PubMed

Ueberschaar N, Dahse HM, Bretschneider T, Hertweck C (2013) Rational design of an apoptosis-inducing photoreactive DNA intercalator. Angew Chem Int Ed Engl 52(24), 6185-6189. Details PubMed

Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C (2013) Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. J Am Chem Soc 135(46), 17408-17416. Details PubMed

Behnken S, Hertweck C (2012) Anaerobic bacteria as producers of antibiotics. Appl Microbiol Biotechnol 96(1), 61-67. Details PubMed

Behnken S, Hertweck C (2012) Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP. PLOS One 7(1), e29609. Details PubMed

Behnken S, Lincke T, Kloss F, Ishida K, Hertweck C (2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51(10), 2425-2428. Details PubMed

Bretschneider T, Zocher G, Unger M, Scherlach K, Stehle T, Hertweck C (2012) A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat Chem Biol 8(2), 154-161. Details PubMed

Ding L, Dahse HM, Hertweck C (2012) Cytotoxic alkaloids from Fusarium incarnatum associated with the mangrove tree Aegiceras corniculatum. J Nat Prod 75(4), 617-621. Details PubMed

Henrot M, Richter ME, Maddaluno J, Hertweck C, De Paolis M (2012) Convergent asymmetric synthesis of (+)-aureothin employing an oxygenase-mediated resolution step. Angew Chem Int Ed Engl 51(38), 9587-9591. Details PubMed

Ishida K, Lincke T, Hertweck C (2012) Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis. Angew Chem Int Ed Engl 51(22), 5470-5474. Details PubMed

Jensen K, Niederkrüger H, Zimmermann K, Vagstad AL, Moldenhauer J, Brendel N, Frank S, Pöplau P, Kohlhaas C, Townsend CA, Oldiges M, Hertweck C, Piel J (2012) Polyketide proofreading by an acyltransferase-like enzyme. Chem Biol 19(3), 329-339. Details PubMed

Kusari S, Hertweck C, Spiteller M (2012) Chemical ecology of endophytic fungi: origins of secondary metabolites. Chem Biol 19(7), 792-798. Details PubMed

Moebius N, Ross C, Scherlach K, Rohm B, Roth M, Hertweck C (2012) Biosynthesis of the respiratory toxin bongkrekic acid in the pathogenic bacterium Burkholderia gladioli. Chem Biol 19(9), 1164-1174. Details PubMed Open Access PDF

Richter M, Busch B, Ishida K, Moore BS, Hertweck C (2012) Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. Chembiochem 13(15), 2196-2199. Details PubMed

Sarkar A, Funk AN, Scherlach K, Horn F, Schroeckh V, Chankhamjon P, Westermann M, Roth M, Brakhage AA, Hertweck C, Horn U (2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71. Details PubMed

Sasso S, Pohnert G, Lohr M, Mittag M, Hertweck C (2012) Microalgae in the postgenomic era: a blooming reservoir for new natural products. FEMS Microbiol Rev 36(4), 761-785. Details PubMed

Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51(40), 10064-10068. Details PubMed

Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C (2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472. Details PubMed

Scherlach K, Brendel N, Ishida K, Dahse HM, Hertweck C (2012) Photochemical oxazole-nitrile conversion downstream of rhizoxin biosynthesis and its impact on antimitotic activity. Org Biomol Chem 10(30), 5756-5759. Details PubMed

Scherlach K, Busch B, Lackner G, Paszkowski U, Hertweck C (2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618. Details PubMed

Silipo A, Leone MR, Lanzetta R, Parrilli M, Lackner G, Busch B, Hertweck C, Molinaro A (2012) Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydr Res 347(1), 95-98. Details PubMed

Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, Li W, Kniemeyer O, Schroeckh V, Hertweck C, Hube B, White TC, Platzer M, Guthke R, Heitman J, Wöstemeyer J, Zipfel PF, Monod M, Brakhage AA (2011) Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol 12(1), R7. Details PubMed

Ding L, Maier A, Fiebig HH, Görls H, Lin WH, Peschel G, Hertweck C (2011) Divergolides A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis. Angew Chem Int Ed Engl 50(7), 1630-1634. Details PubMed

Ding L, Maier A, Fiebig HH, Lin WH, Hertweck C (2011) A family of multicyclic indolosesquiterpenes from a bacterial endophyte. Org Biomol Chem 9(11), 4029-4031. Details PubMed

Fries A, Bretschneider T, Winkler R, Hertweck C (2011) A ribonucleotide reductase-like electron transfer system in the nitroaryl-forming N-oxygenase AurF. Chembiochem 12(12), 1832-1835. Details PubMed

Gee JE, Glass MB, Lackner G, Helsel LO, Daneshvar M, Hollis DG, Jordan J, Morey R, Steigerwalt A, Hertweck C (2011) Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLOS One 6(1), e15731. Details PubMed

Gressler M, Zaehle C, Scherlach K, Hertweck C, Brock M (2011) Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus terreus. Chem Biol 18(2), 198-209. Details PubMed

Hertweck C (2011) Biosynthesis and charging of pyrrolysine, the 22nd genetically encoded amino acid. Angew Chem Int Ed Engl 50(41), 9540-9541. Details PubMed

Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, Gershenzon J, Haas H, Brakhage AA (2011) The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol 82(1), 39-53. Details PubMed

Kusebauch B, Brendel N, Kirchner H, Dahse HM, Hertweck C (2011) Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line. Chembiochem 12(15), 2284-2288. Details PubMed

Kusebauch B, Scherlach K, Kirchner H, Dahse HM, Hertweck C (2011) Antiproliferative effects of ester- and amide-functionalized rhizoxin derivatives. ChemMedChem 6(11), 1998-2001. Details PubMed

Lackner G, Hertweck C (2011) Impact of endofungal bacteria on infection biology, food safety, and drug development. PLOS Pathog 7(6), e1002096. Details PubMed

Lackner G, Moebius N, Hertweck C (2011) Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5(2), 252-261. Details PubMed

Lackner G, Moebius N, Partida-Martinez L, Hertweck C (2011) Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus. J Bacteriol 193(3), 783-784. Details PubMed

Lackner G, Moebius N, Partida-Martinez LP, Boland S, Hertweck C (2011) Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics 12, 210. Details PubMed

Liaimer A, Jenke-Kodama H, Ishida K, Hinrichs K, Stangeland J, Hertweck C, Dittmann E (2011) A polyketide interferes with cellular differentiation in the symbiotic cyanobacterium Nostoc punctiforme. Environ Microbiol Rep 3(5), 550-558. Details PubMed

Nett M, Hertweck C (2011) Farinamycin, a quinazoline from Streptomyces griseus. J Nat Prod 74(10), 2265-2268. Details PubMed

Nützmann HW, Reyes-Dominguez Y, Scherlach K, Schroeckh V, Horn F, Gacek A, Schümann J, Hertweck C, Strauss J, Brakhage AA (2011) Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A 108(34), 14282-14287. Details PubMed

Regueira TB, Kildegaard KR, Hansen BG, Mortensen UH, Hertweck C, Nielsen J (2011) Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol 77(9), 3035-3043. Details PubMed

Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325. Details PubMed

Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50(42), 9843-9847. Details PubMed

Scherlach K, Sarkar A, Schroeckh V, Dahse HM, Roth M, Brakhage AA, Horn U, Hertweck C (2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839. Details PubMed

Ueberschaar N, Ndejouong Ble S, Ding L, Maier A, Fiebig HH, Hertweck C (2011) Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus. Bioorg Med Chem Lett 21(19), 5839-5841. Details PubMed

Vödisch M, Scherlach K, Winkler R, Hertweck C, Braun HP, Roth M, Haas H, Werner ER, Brakhage AA, Kniemeyer O (2011) Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res 10(5), 2508-2524. Details PubMed

Weiz AR, Ishida K, Makower K, Ziemert N, Hertweck C, Dittmann E (2011) Leader peptide and a membrane protein scaffold guide the biosynthesis of the tricyclic peptide microviridin. Chem Biol 18(11), 1413-1421. Details PubMed

Winter JM, Behnken S, Hertweck C (2011) Genomics-inspired discovery of natural products. Curr Opin Chem Biol 15(1), 22-31. Details PubMed

Xu Z, Ding L, Hertweck C (2011) A branched extender unit shared between two orthogonal polyketide pathways in an endophyte. Angew Chem Int Ed Engl 50(20), 4667-4670. Details PubMed

Zocher G, Richter ME, Müller U, Hertweck C (2011) Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase. J Am Chem Soc 133(7), 2292-2302. Details PubMed

Abdou R, Scherlach K, Dahse HM, Sattler I, Hertweck C (2010) Botryorhodines A-D, antifungal and cytotoxic depsidones from Botryosphaeria rhodina, an endophyte of the medicinal plant Bidens pilosa. Phytochemistry 71(1), 110-116. Details PubMed

Bergmann S, Funk AN, Scherlach K, Schroeckh V, Shelest E, Horn U, Hertweck C, Brakhage AA (2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24), 8143-8149. Details PubMed Open Access PDF Supplement

Bruns S, Seidler M, Albrecht D, Salvenmoser S, Remme N, Hertweck C, Brakhage AA, Kniemeyer O, Müller FM (2010) Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics 10(17), 3097-3107. Details PubMed

Ding L, Münch J, Goerls H, Maier A, Fiebig HH, Lin WH, Hertweck C (2010) Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorg Med Chem Lett 20(22), 6685-6687. Details PubMed

Gomes PB, Nett M, Dahse HM, Hertweck C (2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464. Details PubMed

Ishida K, Lincke T, Behnken S, Hertweck C (2010) Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J Am Chem Soc 132(40), 13966-13968. Details PubMed

Kroiss J, Kaltenpoth M, Schneider B, Schwinger MG, Hertweck C, Maddula RK, Strohm E, Svatos A (2010) Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring. Nat Chem Biol 6(4), 261-263. Details PubMed

Krügel H, Licht A, Biedermann G, Petzold A, Lassak J, Hupfer Y, Schlott B, Hertweck C, Platzer M, Brantl S, Saluz HP (2010) Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. FEMS Microbiol Lett 313(2), 155-163. Details PubMed

Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C (2010) Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line. Angew Chem Int Ed Engl 49(8), 1460-1464. Details PubMed

Leone MR, Lackner G, Silipo A, Lanzetta R, Molinaro A, Hertweck C (2010) An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49(41), 7476-7480. Details PubMed

Lincke T, Behnken S, Ishida K, Roth M, Hertweck C (2010) Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew Chem Int Ed Engl 49(11), 2011-2013. Details PubMed

Rohm B, Scherlach K, Hertweck C (2010) Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli. Org Biomol Chem 8(7), 1520-1522. Details PubMed

Rohm B, Scherlach K, Möbius N, Partida-Martinez LP, Hertweck C (2010) Toxin production by bacterial endosymbionts of a Rhizopus microsporus strain used for tempe/sufu processing. Int J Food Microbiol 136(3), 368-371. Details PubMed

Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29), 10136-10141. Details PubMed

Scherlach K, Boettger D, Remme N, Hertweck C (2010) The chemistry and biology of cytochalasans. Nat Prod Rep 27(6), 869-886. Details PubMed

Scherlach K, Schuemann J, Dahse HM, Hertweck C (2010) Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans. J Antibiot (Tokyo) 63(7), 375-377. Details PubMed

Tchize Ndejouong Ble S, Sattler I, Maier A, Kelter G, Menzel KD, Fiebig HH, Hertweck C (2010) Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis. J Antibiot (Tokyo) 63(7), 359-363. Details PubMed

Werneburg M, Busch B, He J, Richter ME, Xiang L, Moore BS, Roth M, Dahse HM, Hertweck C (2010) Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc 132(30), 10407-10413. Details PubMed Open Access

Ziemert N, Ishida K, Weiz A, Hertweck C, Dittmann E (2010) Exploiting the natural diversity of microviridin gene clusters for discovery of novel tricyclic depsipeptides. Appl Environ Microbiol 76(11), 3568-3574. Details PubMed

Hertweck C (2009) Hidden biosynthetic treasures brought to light. Nat Chem Biol 5(7), 450-452. Details PubMed

Ishida K, Welker M, Christiansen G, Cadel-Six S, Bouchier C, Dittmann E, Hertweck C, Tandeau de Marsac N (2009) Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol 75(7), 2017-2026. Details PubMed

Kusebauch B, Busch B, Scherlach K, Roth M, Hertweck C (2009) Polyketide-chain branching by an enzymatic Michael addition. Angew Chem Int Ed Engl 48(27), 5001-5004. Details PubMed

Lackner G, Möbius N, Scherlach K, Partida-Martinez LP, Winkler R, Schmitt I, Hertweck C (2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986. Details PubMed

Lackner G, Partida-Martinez LP, Hertweck C (2009) Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17(12), 570-576. Details PubMed

Möbius N, Hertweck C (2009) Fungal phytotoxins as mediators of virulence. Curr Opin Plant Biol 12(4), 390-398. Details PubMed

Ndejouong Ble S, Sattler I, Dahse HM, Kothe E, Hertweck C (2009) Isoflavones with unusually modified B-rings and their evaluation as antiproliferative agents. Bioorg Med Chem Lett 19(22), 6473-6476. Details PubMed

Osada H, Hertweck C (2009) Exploring the chemical space of microbial natural products. Curr Opin Chem Biol 13(2), 133-134. Details PubMed

Salnikov ES, Friedrich H, Li X, Bertani P, Reissmann S, Hertweck C, O'Neil JD, Raap J, Bechinger B (2009) Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy. Biophys J 96(1), 86-8100. Details PubMed

Scherlach K, Hertweck C (2009) Triggering cryptic natural product biosynthesis in microorganisms. Org Biomol Chem 7(9), 1753-1760. Details PubMed

Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, Schuemann J, Martin K, Hertweck C, Brakhage AA (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34), 14558-14563. Details PubMed

Xu Z, Metsä-Ketelä M, Hertweck C (2009) Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives. J Biotechnol 140(1-2), 107-113. Details PubMed

Brakhage AA, Schuemann J, Bergmann S, Scherlach K, Schroeckh V, Hertweck C (2008) Activation of fungal silent gene clusters: a new avenue to drug discovery. Prog Drug Res 66, 1, 3-1,12. Details PubMed

Fritzsche K, Ishida K, Hertweck C (2008) Orchestration of discoid polyketide cyclization in the resistomycin pathway. J Am Chem Soc 130(26), 8307-8316. Details PubMed

Nguyen T, Ishida K, Jenke-Kodama H, Dittmann E, Gurgui C, Hochmuth T, Taudien S, Platzer M, Hertweck C, Piel J (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat Biotechnol 26(2), 225-233. Details PubMed

Partida-Martinez LP, Bandemer S, Rüchel R, Dannaoui E, Hertweck C (2008) Lack of evidence of endosymbiotic toxin-producing bacteria in clinical Rhizopus isolates. Mycoses 51(3), 266-269. Details PubMed

Schmitt I, Partida-Martinez LP, Winkler R, Voigt K, Einax E, Dölz F, Telle S, Wöstemeyer J, Hertweck C (2008) Evolution of host resistance in a toxin-producing bacterial-fungal alliance. ISME J 2(6), 632-641. Details PubMed

Werneburg M, Hertweck C (2008) Chemoenzymatic total synthesis of the antiproliferative polyketide (+)-(R)-aureothin. Chembiochem 9(13), 2064-2066. Details PubMed

Ziemert N, Ishida K, Liaimer A, Hertweck C, Dittmann E (2008) Ribosomal synthesis of tricyclic depsipeptides in bloom-forming cyanobacteria. Angew Chem Int Ed Engl 47(40), 7756-7759. Details PubMed

Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E (2008) Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa. Appl Environ Microbiol 74(6), 1791-1797. Details PubMed

Bergmann S, Schümann J, Scherlach K, Lange C, Brakhage AA, Hertweck C (2007) Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3(4), 213-217. Details PubMed

Brendel N, Partida-Martinez LP, Scherlach K, Hertweck C (2007) A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex. Org Biomol Chem 5(14), 2211-2213. Details PubMed

Gebhardt P, Dornberger K, Gollmick FA, Gräfe U, Härtl A, Görls H, Schlegel B, Hertweck C (2007) Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill). Bioorg Med Chem Lett 17(9), 2558-2560. Details PubMed

Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A (2007) Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep 24(1), 162-190. Details PubMed

Ishida K, Christiansen G, Yoshida WY, Kurmayer R, Welker M, Valls N, Bonjoch J, Hertweck C, Börner T, Hemscheidt T, Dittmann E (2007) Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety. Chem Biol 14(5), 565-576. Details PubMed

Ishida K, Fritzsche K, Hertweck C (2007) Geminal tandem C-methylation in the discoid resistomycin pathway. J Am Chem Soc 129(42), 12648-12649. Details PubMed

Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C (2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30), 9306-9312. Details PubMed

Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M (2007) Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem 8(13), 1577-1584. Details PubMed

Partida-Martinez LP, de Looss CF, Ishida K, Ishida M, Roth M, Buder K, Hertweck C (2007) Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts. Appl Environ Microbiol 73(3), 793-797. Details PubMed Open Access PDF

Partida-Martinez LP, Groth I, Schmitt I, Richter W, Roth M, Hertweck C (2007) Burkholderia rhizoxinica sp. nov. and Burkholderia endofungorum sp. nov., bacterial endosymbionts of the plant-pathogenic fungus Rhizopus microsporus. Int J Syst Evol Microbiol 57(Pt 11), 2583-2590. Details PubMed Open Access PDF Supplement

Partida-Martinez LP, Hertweck C (2007) A gene cluster encoding rhizoxin biosynthesis in Chembiochem 8(1), 41-45. Details PubMed

Partida-Martinez LP, Monajembashi S, Greulich KO, Hertweck C (2007) Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism. Curr Biol 17(9), 773-777. Details PubMed

Schenk A, Xu Z, Pfeiffer C, Steinbeck C, Hertweck C (2007) Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway. Angew Chem Int Ed Engl 46(37), 7035-7038. Details PubMed

Schümann J, Hertweck C (2007) Molecular basis of cytochalasan biosynthesis in fungi: gene cluster analysis and evidence for the involvement of a PKS-NRPS hybrid synthase by RNA silencing. J Am Chem Soc 129(31), 9564-9565. Details PubMed

Traitcheva N, Jenke-Kodama H, He J, Dittmann E, Hertweck C (2007) Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem 8(15), 1841-1849. Details PubMed

Wangun HV, Dahse HM, Hertweck C (2007) Epicoccamides B-D, glycosylated tetramic acid derivatives from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa. J Nat Prod 70(11), 1800-1803. Details PubMed

Winkler R, Hertweck C (2007) Biosynthesis of nitro compounds. Chembiochem 8(9), 973-977. Details PubMed

Winkler R, Zocher G, Richter I, Friedrich T, Schulz GE, Hertweck C (2007) A binuclear manganese cluster that catalyzes radical-mediated N-oxygenation. Angew Chem Int Ed Engl 46(45), 8605-8608. Details PubMed

Xu Z, Schenk A, Hertweck C (2007) Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids. J Am Chem Soc 129(18), 6022-6030. Details PubMed

Zocher G, Winkler R, Hertweck C, Schulz GE (2007) Structure and action of the N-oxygenase AurF from Streptomyces thioluteus. J Mol Biol 373(1), 65-74. Details PubMed

Ishida K, Maksimenka K, Fritzsche K, Scherlach K, Bringmann G, Hertweck C (2006) The boat-shaped polyketide resistoflavin results from re-facial central hydroxylation of the discoid metabolite resistomycin. J Am Chem Soc 128(45), 14619-14624. Details PubMed

Kniemeyer O, Lessing F, Scheibner O, Hertweck C, Brakhage AA (2006) Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet 49(3), 178-189. Details PubMed

Müller M, He J, Hertweck C (2006) Dissection of the late steps in aureothin biosynthesis. Chembiochem 7(1), 37-39. Details PubMed

Müller M, Kusebauch B, Liang G, Beaudry CM, Trauner D, Hertweck C (2006) Photochemical origin of the immunosuppressive SNF4435C/D and formation of orinocin through Angew Chem Int Ed Engl 45(46), 7835-7838. Details PubMed

Scherlach K, Hertweck C (2006) Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org Biomol Chem 4(18), 3517-3520. Details PubMed

Scherlach K, Partida-Martinez LP, Dahse HM, Hertweck C (2006) Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. J Am Chem Soc 128(35), 11529-11536. Details PubMed

Schümann J, Hertweck C (2006) Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes. J Biotechnol 124(4), 690-703. Details PubMed

Wangun HV, Härtl A, Tam Kiet T, Hertweck C (2006) Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. Org Biomol Chem 4(13), 2545-2548. Details PubMed

Winkler R, Richter ME, Knüpfer U, Merten D, Hertweck C (2006) Regio- and chemoselective enzymatic N-oxygenation in vivo, in vitro, and in flow. Angew Chem Int Ed Engl 45(47), 8016-8018. Details PubMed

Gebhardt P, Gräfe U, Möllmann U, Hertweck C (2005) Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination. Mol Divers 9(1-3), 27-32. Details PubMed

He J, Hertweck C (2005) Functional analysis of the aureothin iterative type I polyketide synthase. Chembiochem 6(5), 908-912. Details PubMed

Herold K, Gollmick FA, Groth I, Roth M, Menzel KD, Möllmann U, Gräfe U, Hertweck C (2005) Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. Chemistry 11(19), 5523-5530. Details PubMed

Partida-Martinez LP, Hertweck C (2005) Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 437(7060), 884-888. Details PubMed

Winkler R, Hertweck C (2005) Sequential enzymatic oxidation of aminoarenes to nitroarenes via hydroxylamines. Angew Chem Int Ed Engl 44(26), 4083-4087. Details PubMed

Xu Z, Jakobi K, Welzel K, Hertweck C (2005) Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide. Chem Biol 12(5), 579-588. Details PubMed

Ziehl M, He J, Dahse HM, Hertweck C (2005) Mutasynthesis of aureonitrile: an aureothin derivative with significantly improved cytostatic effect. Angew Chem Int Ed Engl 44(8), 1202-1205. Details PubMed

Zöllner T, Gebhardt P, Beckert R, Hertweck C (2005) Efficient synthesis of 9- and 13-oxo leucomycin derivatives using hypervalent iodine reagents in solution and on solid support. J Nat Prod 68(1), 112-114. Details PubMed

He J, Müller M, Hertweck C (2004) Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase. J Am Chem Soc 126(51), 16742-16743. Details PubMed

Herold K, Xu Z, Gollmick FA, Grafe U, Hertweck C (2004) Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety. Org Biomol Chem 2(17), 2411-2414. Details PubMed

Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore BS (2004) Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. Chem Biol 11(4), 461-468. Details PubMed

Wangun HV, Berg A, Hertel W, Nkengfack AE, Hertweck C (2004) Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus. J Antibiot (Tokyo) 57(11), 755-758. Details PubMed

Busch B, Hertweck C (0) Evolution of metabolic diversity in polyketide-derived pyrones: using the non-colinear aureothin assembly line as a model system. Phytochemistry 70(15-16), 1833-1840. Details PubMed