Gerald Lackner

Dr. Gerald Lackner

Synthetic Microbiology · Head

Phone: +49 3641 532-1104 Fax: +49 3641 532-2104 Email: gerald.lackner@leibniz-hki.de

Publications

Brandenburger E, Braga D, Kombrink A, Lackner G, Gressler J, Künzler M, Hoffmeister D (2018) Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases. Fungal Genet Biol 112, 55-63. Details PubMed

Guo H, Schmidt A, Stephan P, Raguž L, Braga D; Kaiser M, Dahse HM, Weigel C, Lackner G, Beemelmanns C (2018) Precursor-directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins ChemBioChem [Accepted] Details PubMed

Klapper M, Braga D, Lackner G, Herbst R, Stallforth P (2018) Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase Cell Chem Biol [In press] Details

Braga D, Lackner G (2017) One ring to fight them all: The sulfazecin story Cell Chem Biol 24(1), 1-2. (Review) Details PubMed Open Access

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D (2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol , Details PubMed

Brandenburger E, Gressler M, Leonhardt R, Lackner G, Habel A, Hertweck C, Brock M, Hoffmeister D (2017) (2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol [Accepted] Details

Lackner G, Peters EE, Helfrich EJN, Piel J (2017) Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. Proc Natl Acad Sci U S A 114(3), E347-E356. Details PubMed

Fuchs S W, Lackner G, Morinaka B I, Morishita Y, Asai T, Riniker S, Piel J (2016) A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution Angew Chem Int Ed Engl 55(40), 12330-12333. Details PubMed

Shah F, Nicolas C, Bentzer J, Ellström M, Smits M, Rineau F, Canbäck B, Floudas D, Carleer R, Lackner G, Braesel J, Hoffmeister D, Henrissat B, Ahrén D, Johansson T, Hibbett DS, Martin F, Persson P, Tunlid A (2016) Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors. New Phytol 209, 1705-1719. Details PubMed

Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D (2016) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204. Details PubMed Open Access

Graupner K, Lackner G, Hertweck C (2015) Genome Sequence of Mushroom Soft-Rot Pathogen Janthinobacterium agaricidamnosum. Genome Announc. 3(2), pii: e00277-15. Details PubMed Open Access

Kalb D, Heinekamp T, Lackner G, Scharf DH, Dahse H-M, Brakhage AA, Hoffmeister D (2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600. Details PubMed

Kalb D, Lackner G, Rappe M, Hoffmeister D (2015) Activity of α-aminoadipate reductase depends on the N-terminally extending domain. Chembiochem 16, 1426-1430. Details PubMed

Karlsson M, Durling MB, Choi J, Kosawang C, Lackner G, Tzelepis GD, Nygren K, Dubey MK, Kamou N, Levasseur A, Zapparata A, Wang J, Amby DB, Jensen B, Sarrocco S, Panteris E, Lagopodi AL, Pöggeler S, Vannacci G, Collinge DB, Hoffmeister D, Henrissat B, Lee YH, Jensen DF (2015) Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys rosea. Genome Biol Evol 7, 465-480. Details PubMed

Uzum Z, Silipo A, Lackner G, De Felice A, Molinaro A, Hertweck C (2015) Structure, Genetics and Function of an Exopolysaccharide Produced by a Bacterium Living within Fungal Hyphae. Chembiochem 16(3), 387-392. Details PubMed

Chankhamjon P, Boettger-Schmidt D, Scherlach K, Urbansky B, Lackner G, Kalb D, Dahse HM, Hoffmeister D, Hertweck C (2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413. Details PubMed

Hori C, Ishida T, Igarashi K, Samejima M, Suzuki H, Master E, Ferreira P, Ruiz-Dueñas FJ, Held B, Canessa P, Larrondo LF, Schmoll M, Druzhinina IS, Kubicek CP, Gaskell JA, Kersten P, St John F, Glasner J, Sabat G, Splinter BonDurant S, Syed K, Yadav J, Mgbeahuruike AC, Kovalchuk A, Asiegbu FO, Lackner G, Hoffmeister D, Rencoret J, Gutiérrez A, Sun H, Lindquist E, Barry K, Riley R, Grigoriev IV, Henrissat B, Kües U, Berka RM, Martínez AT, Covert SF, Blanchette RA, Cullen D (2014) Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood. PLOS Genet 10, e1004759. Details PubMed

Kalb D, Lackner G, Hoffmeister D (2014) Functional and phylogenetic divergence of fungal adenylate-forming reductases. Appl Environ Microbiol 80, 6175-6183. Details PubMed

Moebius N, Uzüm Z, Dijksterhuis J, Lackner G, Hertweck C (2014) Active invasion of bacteria into living fungal cells. Elife , e03007. Details PubMed

Kalb D, Lackner G, Hoffmeister D (2013) Fungal peptide synthetases – an update on functions and specificity signatures Fungal Biology Reviews 27, 43-50. Details

Lackner G, Bohnert M, Wick J, Hoffmeister D (2013) Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. Chem Biol 20, 1101-1106. Details PubMed

Scherlach K, Lackner G, Graupner K, Pidot S, Bretschneider T, Hertweck C (2013) Biosynthesis and mass spectrometric imaging of tolaasin, the virulence factor of brown blotch mushroom disease. Chembiochem 14(18), 2439-2443. Details PubMed

Steinchen W, Lackner G, Yasmin S, Schrettl M, Dahse HM, Haas H, Hoffmeister D (2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79, 6670-6676. Details PubMed

Graupner K, Scherlach K, Bretschneider T, Lackner G, Roth M, Gross H, Hertweck C (2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51(52), 13173-13177. Details PubMed

Lackner G, Misiek M, Braesel J, Hoffmeister D (2012) Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet Biol 49, 996-991003. Details PubMed

Scherlach K, Busch B, Lackner G, Paszkowski U, Hertweck C (2012) Symbiotic cooperation in the biosynthesis of a phytotoxin. Angew Chem Int Ed Engl 51(38), 9615-9618. Details PubMed

Silipo A, Leone MR, Lanzetta R, Parrilli M, Lackner G, Busch B, Hertweck C, Molinaro A (2012) Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4). Carbohydr Res 347(1), 95-98. Details PubMed

Wackler B, Lackner G, Chooi YH, Hoffmeister D (2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids. Chembiochem 13, 1798-1804. Details PubMed

Gee JE, Glass MB, Lackner G, Helsel LO, Daneshvar M, Hollis DG, Jordan J, Morey R, Steigerwalt A, Hertweck C (2011) Characterization of Burkholderia rhizoxinica and B. endofungorum isolated from clinical specimens. PLOS One 6(1), e15731. Details PubMed

Lackner G, Hertweck C (2011) Impact of endofungal bacteria on infection biology, food safety, and drug development. PLOS Pathog 7(6), e1002096. Details PubMed

Lackner G, Moebius N, Hertweck C (2011) Endofungal bacterium controls its host by an hrp type III secretion system. ISME J 5(2), 252-261. Details PubMed

Lackner G, Moebius N, Partida-Martinez L, Hertweck C (2011) Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus. J Bacteriol 193(3), 783-784. Details PubMed

Lackner G, Moebius N, Partida-Martinez LP, Boland S, Hertweck C (2011) Evolution of an endofungal lifestyle: Deductions from the Burkholderia rhizoxinica genome. BMC Genomics 12, 210. Details PubMed

Leone MR, Lackner G, Silipo A, Lanzetta R, Molinaro A, Hertweck C (2010) An unusual galactofuranose lipopolysaccharide that ensures the intracellular survival of toxin-producing bacteria in their fungal host. Angew Chem Int Ed Engl 49(41), 7476-7480. Details PubMed

Lackner G, Möbius N, Scherlach K, Partida-Martinez LP, Winkler R, Schmitt I, Hertweck C (2009) Global distribution and evolution of a toxinogenic Burkholderia-Rhizopus symbiosis. Appl Environ Microbiol 75(9), 2982-2986. Details PubMed

Lackner G, Partida-Martinez LP, Hertweck C (2009) Endofungal bacteria as producers of mycotoxins. Trends Microbiol 17(12), 570-576. Details PubMed

Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C (2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30), 9306-9312. Details PubMed

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