Sandra Höfgen

Dr. Sandra Höfgen

Biobricks of Microbial Natural Product Syntheses

Phone: +49 3641 532-1726 Fax: +49 3641 532-2726 Email: sandra.hoefgen@leibniz-hki.de

Topics
Publications

Furukawa T, Scheven MT, Misslinger M, Zhao C, Hoefgen S, Gsaller F, Lau J, Jöchl C, Donaldson I, Valiante V, Brakhage AA, Bromley MJ, Haas H, Hortschansky P (2020) The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition. Nucleic Acids Res 48(7), 3567-3590. Details PubMed Open Access PDF

Janevska S, Ferling I, Jojić K, Rautschek J, Hoefgen S, Proctor RH, Hillmann F, Valiante V (2020) Self-protection against the sphingolipid biosynthesis inhibitor fumonisin B1 is conferred by a FUM cluster-encoded ceramide synthase. mBio 11(3), e00455-20. Details PubMed Open Access PDF

Krishnan BP, Prieto-Lopez LO, Hoefgen S, Xue L, Wang S, Valiante V, Cui J (2020) A thermo-magneto-responsive smart biocatalyst for malonyl Coenzyme A synthesis. ACS Appl Mater Interfaces 12(18), 20982-20990. Details PubMed

Kufs JE, Hoefgen S, Rautschek J, Bissell AU, Graf C, Fiedler J, Braga D, Regestein L, Rosenbaum MA, Thiele J, Valiante V (2020) Rational design of flavonoid production routes using combinatorial and precursor-directed biosynthesis. ACS Synth Biol [Epub ahead of print] Details PubMed

Manfiolli AO, Siqueira FS, Dos Reis TF, Van Dijck P, Schrevens S, Hoefgen S, Föge M, Straßburger M, de Assis LJ, Heinekamp T, Rocha MC, Janevska S, Brakhage AA, Malavazi I, Goldman GH, Valiante V (2019) Mitogen-activated protein kinase cross-talk interaction modulates the production of melanins in Aspergillus fumigatus. mBio 10(2), e00215-19. Details PubMed Open Access PDF

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V (2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51. Details PubMed Open Access

Hoefgen S, Dahms SO, Oertwig K, Than ME (2015) The amyloid precursor protein shows a pH-dependent conformational switch in its E1 domain. J Mol Biol 427(2), 433-442. Details PubMed

Coburger I, Hoefgen S, Than ME (2014) The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture. Biol Chem 395(5), 485-498. Details PubMed

Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms SO, Than ME (2014) Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain. J Struct Biol 187(1), 30-37. Details PubMed

Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR (2013) The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain. PLOS One 8(8), e72177. Details PubMed

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME (2010) Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A 107(12), 5381-5386. Details PubMed