Janis Fricke
Main Research Areas
  • Biosynthetic pathways
  • Natural products
  • fungal genomics
Topics
Curriculum vitae

Professional Career

2017 - 2020 Phd student "natural product chemistry" - Doctoral thesis: Biochemical and genetic basis of indole alkaloid biosynthesis in basidiomycetes and biotechnological synthesis of psilocybin  - Friedrich-Schiller University Jena
2013 - 2017 Master studies "chemical biology" - Master thesis: Heterologous production and biochemical characterization of prenyltransferases and polyketidsynthases from basidiomycetes - Friedrich-Schiller University Jena
2010 -2013 Bachelor studies "biology" - Bachelor thesis: Quantification of neuropeptides during the postmetamorphic development of the antennal lobe in Drosophila melanogaster - Philipps-University Marburg


 

  

Awards · Appointments · Scientific Activities

2018  medac-research price
2018  PHOENIX Pharmazie Wissenschaftspreis


          
Publications

Blei F, Dörner S, Fricke S, Baldeweg F, Trottmann F, Komor AJ, Meyer F, Hertweck C, Hoffmeister D (2020) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J 26(3), 729-734. Details PubMed Open Access PDF

Demmler R, Fricke J, Dörner S, Gressler M, Hoffmeister D (2020) S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms. ChemBioChem 21(9), 1364-1371. Details PubMed Open Access PDF

Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285. Details PubMed Open Access PDF

Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. (Review) Details PubMed

Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20(22), 2824-2829. Details PubMed

Blei F, Baldeweg F, Fricke J, Hoffmeister D (2018) Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions. Chem Eur J 24(40), 10028-10031. Details PubMed

Blei F, Fricke J, Wick J, Slot JC, Hoffmeister D (2018) Iterative L-tryptophan methylation in Psilocybe evolved by sub-domain duplication. ChemBioChem [Accepted] Details PubMed

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V (2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51. Details PubMed Open Access

Braesel J, Fricke J, Schwenk D, Hoffmeister D (2017) Biochemical and genetic basis of orsellinic acid biosynthesis and prenylation in a stereaceous basidiomycete. Fungal Genet Biol 98, 12-19. Details

Fricke J, Blei F, Hoffmeister D (2017) Enzymatic synthesis of psilocybin Angew Chem Int Ed 56, 12352-12355. Details