- Flow of molecular information concerning host/pathogen interactions; virulence and host preference
- Host models: human material, chicken embryones, mouse
- Methods: comparative genomics, dual RNA-Seq, EVIAT,in vivo ChIP-Seq, molecular imaging, single infection
- Genomics of microbial communities (metagenomics)
- Technological developments: UV-Laser ChIP-Seq, hyperspectral imaging
|Since 1995||Professor in cell and molecular biology at the Friedrich-Schiller-University Jena|
|1994||Habilitation in molecular biology (Dr. rer. nat. habil.) at the Friedrich-Schiller-University Jena|
|Since 1993||Supervisor (cell- and molecular biology) at the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute – (HKI) Jena|
|1990-1993||Senior group and project leader at the IRBM (American-Italian Research Institute ) in Rome, Italy. Technological developments and studies in virus latency concerning Herpes simplex|
|1987-1990||Research associate at the Friedrich Miescher-Institute in Basel, Switzerland, studies in gene regulations; development of technologies for studying gene expressions in vivo|
|1984-1987||Postdoc at the Friedrich Miescher-Institut in Basel, Switzerland; studies in chicken vitellogenin-II-gene regulation; development of methods for studying gene expressions in vivo|
|1984||PhD in philosophy (Dr. phil.) at the University Zurich, Switzerland
Dealing with "small nuclear RNAs" (strukture, function) at the University Zurich, Switzerland
|1980||Diploma (Dipl. phil.): characterisation and function of sexpeptides and free amino acids in Drosophila macrospina at the University Zurich, Switzerland|
|1978-1980||Diploma programme at the University Zurich, Switzerland (biochemistry, insect biochemistry, genetics, physical chemistry)|
|1979-1984||Training and research assistant (insect biochemistry) at the University Zurich, Switzerland|
|1975-1978||Bachelor programme at the University Zurich, Switzerland (chemistry, biology, physics, mathematics)|
Awards · Appointments · Scientific Activities
|Since 2007||Principal Investigator at the excellence graduate school Jena School for Microbial Communication (JSMC)|
|Since 2006||Principal Investigator at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)|
|Since 2005||Member of the scientific board of the Vietnam Red Cross Society|
|Since 2004||Principal Investigator at the International Max Planck Research School on The Exploration of Ecological Interactions with Molecular and Chemical Techniques (IMPRS)|
|Since 1997||Planning and contribution of startups|
|1997||Appointment to the management board of „BioRegio“ Jena (research political organisation, forschungspolitische Organisation, cross-strategic issues, company establishments, key areas of research, projects, technology transfer, etc.)|
|Since 1992||Consulting and evaluation activities for several national and international, scientific, industrial and state organisations and banks
Editorial work for several publishers
Member of several editorial boards
(2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14(9), 841-843.
(2017) Mapping metabolites from rough terrain: laser ablation electrospray ionization on non-flat samples. RSC Adv 7, 9045-9050.
(2017) Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging. Sci Rep 7, 2217.
(2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16.
(2017) High-intensity UV laser CHIP-seq for the study of protein-DNA interactions in living cells. Nat Commun 8(1), 1303.
(2017) Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Sci Rep 7, 44434.
(2016) Purification of infectious and non-infectious chlamydial particles using iodixanol for density gradient preparation. J Microbiol Methods 128, 20-23.
(2016) Chlamydiacae: Polymorphic membrane proteins make the difference. Virulence 7(1), 3-4. (Review)
(2016) Microbial diversity and parasitic load in tropical fish of different environmental conditions PLOS ONE 11(3), e0151594.
(2016) Metagenomic analysis between free-living and cultured Epinephelus fuscoguttatus under different environmental conditions in Indonesian waters Mar Pollut Bull 110(2), 726-734.
(2016) Hyperspectral imaging using intracellular spies: quantitative real-time measurement of intracellular parameters in vivo during interaction of the pathogenic fungus Aspergillus fumigatus with human monocytes PLOS ONE 11(10), e0163505.
(2016) Microbiome analysis and detection of pathogenic bacteria of Penaeus monodon from Jakarta Bay and Bali Mar Pollut Bull 110(2), 718-725.
(2016) Dual acting neuraminidase inhibitors open new opportunities to disrupt the lethal synergism between Streptococcus pneumoniae and influenza virus Front Microbiol 7, 375.
(2015) Identification of in vivo-induced bacterial protein antigens during calf infection with Chlamydia psittaci Int J Med Microbiol 305(3), 310-321.
(2015) Expression of the toxin-antitoxin genes yefM, yoeB in human Lactobacillus rhamnosus isolates J Basic Microbiol 55(8), 982-991.
(2015) Population structure of the Indonesian giant tiger shrimp Penaeus monodon: a window into evolutionary similarities between paralogous mitochondrial DNA sequences and their genomes. Ecology and Evolution 5(17), 3570-3584.
(2015) Antipneumococcal activity of neuramidase inhibiting artocarpin Int J Med Microbiol 305, 289-297.
(2014) Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin. Int J Med Microbiol 304(5-6), 542-553.
(2014) Comparing 2-[(18)F]fluoro-2-deoxy-D-glucose and [(68)Ga]gallium-citrate translocation in Arabidopsis thaliana. Nucl Med Biol 41(9), 737-743.
(2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155.
(2014) Chlamydia psittaci: New insights into genomic diversity, clinical pathology, host-pathogen interaction and anti-bacterial immunity. Int J Med Microbiol 304(7), 877-893.
(2013) The plasmidome of a Salmonella enterica serovar Derby isolated from pork meat. Plasmid 69(3), 202-210.
(2013) Dynamic behaviour of selected PET tracers in embryonated chicken eggs. Rev Esp Med Nucl Imagen Mol. 32(6), 371-377.
(2013) Automated segmentation and object classification of CT images: Application to in vivo molecular imaging of avian embryos. Int J Biomed Imaging 2013, 508474-508474.
(2013) Identification and characterization of toxin-antitoxin systems in strains of Lactobacillus rhamnosus isolated from humans. Anaerobe 22, 82-89.
(2013) Identification of gene expression profiles in HeLa cells and HepG2 cells infected with Coxsackievirus B3. J Virol Methods 187(1), 190-194.
(2012) Distinct intensity of host-pathogen interactions in Chlamydia psittaci- and Chlamydia abortus-infected chicken embryos. Infect Immun 80(9), 2976-2988.
(2012) Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins. J Cell Biochem 113(5), 1744-1753.
(2012) The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif. Nucleic Acids Res 40(17), 8309-8324.
(2012) The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens. PLOS One 7(4), e35097-e35097.
(2012) Insights into bone metabolism of avian embryos in ovo via 3D and 4D 18F-fluoride positron emission tomography. Mol Imaging Biol 14(6), 688-698.
(2011) Functional interaction between type III-secreted protein IncA of Chlamydophila psittaci and human G3BP1. PLOS One 6(1), e16692-e16692.
(2011) Motion-artifact-free in vivo imaging utilizing narcotized avian embryos in ovo. Mol Imaging Biol 13(2), 208-214.
(2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum. Appl Environ Microbiol 77, 6117-6124.
(2011) Complete genome sequences of four mammalian isolates of Chlamydophila psittaci. J Bacteriol 193(16), 4258-4258.
(2011) Full-length de novo sequence of the Chlamydophila psittaci type strain, 6BC. J Bacteriol 193(10), 2662-2663.
(2011) Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8), 1130-1148.
(2011) Paralogous mitochondrial control region in the giant tiger shrimp, Penaeus monodon (F.) affects population genetics inference: A cautionary tale. Mol Phylogenet Evol 58(2), 404-408.
(2011) Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT. Appl Radiat Isot 69(6), 852-857.
(2010) Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. FEMS Microbiol Lett 313(2), 155-163.
(2010) Fast short-fragment PCR for rapid and sensitive detection of shrimp viruses J Virol Methods 168(1-2), 262-266.
(2008) Two-laser, large-field hyperspectral microarray scanner for the analysis of multicolor microarrays Anal Chem 80(20), 7706-7713.
(2007) Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2), 250-254.