
Prof. Dr. Marc Thilo Figge
Applied Systems Biology
Phone: +49 3641 532-1416 Fax: +49 3641 532-2416 Email: thilo.figge@leibniz-hki.de
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
Since 2011 | Professor (W2) for Applied Systems Biology, Friedrich-Schiller-University Jena |
2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Since 2011 | Adjunct Fellow at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
Since 2011 | Membership in the faculties of the „Jena School for Microbial Communication“ (JSMC) and „International Leibniz Research School“ (ILRS) |
(2019) Automated tracking of label-free cells with enhanced recognition of whole tracks. Sci Rep 9, 3317. Details PubMed Open Access PDF Supplement
(2019) Comparative assessment of aspergillosis by virtual infection modeling. Front Immunol 10, 142. Details PubMed Open Access PDF Supplement
(2019) Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen. Frontiers in Immunology 10(2537), Details Open Access PDF
(2019) The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains. Environ Microbiol 21(12), 4563-4581. Details PubMed Open Access PDF Supplement
(2019) Regulation of the germinal center reaction and somatic hypermutation dynamics by homologous recombination. J Immunol [Epub ahead of print] Details PubMed
(2019) Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation. Oncogene 38(24), 4773-4787. Details PubMed
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials [Epub ahead of print] Details PubMed Open Access PDF
(2019) Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections. Preprint published on bioRxiv. Details Open Access PDF
(2019) Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus. Preprint published on bioRxiv. Details Open Access PDF
(2019) Künstliche Intelligenz für die biomedizinische Bildgebung. GIT Labor-Fachzeitschrift [Epub ahead of print] Details Open Access PDF
(2019) Coding of experimental conditions in microfluidic droplet assays using colored beads and machine learning supported image analysis. Small 15(4), e1802384. Details PubMed
(2019) Clinical S. aureus isolates vary in their virulence to promote adaptation to the host. Toxins 11(3), pii: E135. Details PubMed Open Access PDF Supplement
(2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9(3), e00915-18. Details PubMed Open Access
(2018) Hessian-based quantitative image analysis of host- pathogen confrontation assays. Cytometry A 93(3), 346-356. Details PubMed Open Access PDF
(2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement
(2018) Modeling hemolytic-uremic syndrome: in-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459. Details PubMed Open Access PDF Supplement
(2018) Waffenübergabe im Immunsystem. Laborjournal 4, 40-43. (Review) Details Open Access PDF
(2018) Quantitative bioimage analysis of cell characteristics. Cytometry A 93(3), 278-280. (Review) Details PubMed Open Access PDF
(2018) Drops of blood in focus. LICHTGEDANKEN - The Magazine of the Friedrich Schiller University 3, 26-29. (Review) Details Open Access PDF
(2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370. Details PubMed
(2018) Predictive virtual infection modeling of fungal immune evasion in human whole blood. Front Immunol 9, 560. Details PubMed Open Access PDF Supplement
(2018) Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice. Theranostics 8(14), 3766-3780. Details PubMed Open Access
(2018) Untangling cell tracks: quantifying cell migration by time lapse image data analysis. Cytometry A 93(3), 357-370. Details PubMed Open Access PDF
(2018) Quantitative simulations predict treatment strategies against fungal infections in virtual neutropenic patients. Front Immunol 9, 667. Details PubMed Open Access PDF Supplement
(2017) Migration and interaction tracking for quantitative analysis of phagocyte-pathogen confrontation assays. Medical Image Analysis 36, 172-183. Details PubMed Open Access PDF
(2017) Mast cells acquire MHCII from dendritic cells during skin inflammation. J Exp Med 214(12), 3791-3811. Details PubMed
(2017) Systems Biology of Infection. In: NOVA ACTA LEOPOLDINA (ed.) Crossing Boundaries in Science. Documentation of the Workshop of the German National Academy of Sciences Leopoldina, Weimar, 06/30/2016-07/02/2016, 419, pp. 45-51.Wissenschaftliche Verlagsgesellschaft Stuttgart, Halle (Saale). ISBN: 978-3-8047-3758. (Review) Details Open Access PDF
(2017) Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging. Sci Rep 7, 2217. Details PubMed Open Access PDF
(2017) Fully automated evaluation of total glomerular number and capillary tuft size in murine nephritic kidneys using lightsheet microscopy. J Am Soc Nephrol 28(2), 452-459. Details PubMed
(2017) Dimensionality of motion and binding valency govern receptor-ligand kinetics as revealed by agent-based modeling. Front Immunol 8, 1692. Details PubMed Open Access PDF Supplement
(2017) Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Sci Rep 7, 44434. Details PubMed Open Access PDF Supplement
(2017) Segmentation of clusters by template rotation expectation maximization. Comput Vis Image Underst 152, 64-72. Details Open Access
(2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629. Details PubMed
(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807. Details PubMed Open Access PDF Supplement
(2015) Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils. Medical Image Analysis 20(1), 34-51. Details PubMed
(2015) Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes. Cell Microbiol 17(9), 1259-1276. Details PubMed
(2015) Human neutrophils dump Candida glabrata after intracellular killing. Fungal Genetics and Biology 84, 37-40. Details PubMed
(2015) Image-based Systems Biology: what you get is more than you can see. G.I.T. Laboratory Journal Europe 19, 13-15. Details Open Access
(2015) Image-based Systems Biology. Cytometry A 87(6), 459-461. Details PubMed
(2015) A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. The Journal of Immunology 194(3), 1199-1210. Details PubMed
(2015) Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm. Frontiers in Microbiology 6(549), *authors contributed equally. Details PubMed Open Access
(2015) Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions. Frontiers in Microbiology 6(608), *authors contributed equally. Details PubMed Open Access
(2015) Enhanced and homogeneous oxygen availability during incubation of microfluidic droplets. RSC Advances 5, 101871-101878. Details Open Access PDF Supplement
(2015) Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. Applied Microbiology and Biotechnology 99(23), 10151-10161. Details PubMed
(2015) Image-based Systems Biology of Infection. Cytometry A 87(6), 462-470. Details PubMed
(2015) Quantitative image analysis of cell colocalization in murine bone marrow. Cytometry A 87(6), 503-512, *authors contributed equally. Details PubMed
(2015) Deciphering chemokine properties by a hybrid agent-based model of Aspergillus fumigatus infection in human alveoli. Frontiers in Microbiology 6(503), Details PubMed Open Access
(2015) Automated classification of circulating tumor cells and the impact of inter-observer variability on classifier training and performance. Journal of Immunology Research 2015(Article ID 573165), 9. Details PubMed Open Access
(2014) A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood. PLOS Comput Biol 10(2), e1003479, */⁺authors contributed equally. Details PubMed Open Access
(2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155. Details PubMed Open Access
(2014) Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis. Mycoses 57(Suppl. 3), 56-66, */⁺authors contributed equally. Details PubMed Open Access
(2014) Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach. Cytometry A 85(2), 126-139. Details PubMed
(2014) Agent-based model of human alveoli predicts chemotactic signaling by epithelial cells during early Aspergillus fumigatus infection. PLOS ONE 9(10), e111630. Details PubMed Open Access
(2014) Automated detection of circulating tumor cells with naive Bayesian classifiers. Cytometry A 85(6), 501-511. Details PubMed
(2013) Naive B-cell trafficking is shaped by local chemokine availability and LFA-1-independent stromal interactions. Blood 121(20), 4101-4109. Details PubMed
(2013) Quality control of mitochondria during aging: is there a good and a bad side of mitochondrial dynamics? Bioessays 35(4), 314-322. Details PubMed
(2013) Automated characterization and parameter-free classification of cell tracks based on local migration behavior. PLOS ONE 8(12), e80808. Details PubMed Open Access
(2013) Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets. Lab Chip 13(18), 3707-3713, *authors contributed equally. Details PubMed Open Access
(2013) Germinal center B cells govern their own fate via antibody feedback. J Exp Med 210(3), 457-464. Details PubMed Open Access
(2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. PLOS Comput Biol 8(6), e1002576. Details PubMed Open Access
(2012) Systems biology of microbial infection. Front Microbiol 3, 328. Details PubMed Open Access
(2012) Image-based systems biology: A quantitative approach to elucidate the kinetics of fungal morphologies and virulence. In: Highlight Papers of the German Conference on Bioinformatics 2012 German Conference on Bioinformatics, Jena, GCB. Details PDF
(2012) Agent-based modeling approach of immune defense against spores of opportunistic human pathogenic fungi. Front Microbiol 3, 129. Details PubMed Open Access
(2011) Modelling Intravital Two-Photon Data of Lymphocyte Migration and Interaction In: Molina-París C, Lythe G (eds.) Mathematical Models and Immune Cell Biology pp. 121-139. Springer, Heidelberg. ISBN: 978-1-4419-7724. Details
(2011) Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLOS ONE 6(5), e19591, *authors contributed equally. Details PubMed Open Access
(2010) Modelling cellular aggregation induced by chemotaxis and phototaxis. Math Med Biol 27(4), 373-384. Details PubMed
(2010) Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation. Immunity 33(1), 84-95. Details PubMed Open Access
(2009) Optimization of immunoglobulin substitution therapy by a stochastic immune response model. PLOS ONE 4(5), e5685. Details PubMed Open Access
(2009) Modeling receptor-ligand binding kinetics in immunological synapse formation. The European Physical Journal D 51(1), 153-160. Details
(2009) Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach. Arthritis Rheum 60(9), 2585-2594. Details PubMed Open Access
(2009) Germinal centres seen through the mathematical eye: B-cell models on the catwalk. Trends Immunol 30(4), 157-164. Details PubMed
(2008) Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med 205(13), 3019-3029. Details PubMed Open Access
(2006) Geometrically repatterned immunological synapses uncover formation mechanisms. PLOS Comput Biol 2(11), e171. Details PubMed Open Access
(2004) Molecular dynamics simulation of nanoindentation In: Computer simulation studies incondensed-matter physics XVI pp. 250-255.Springer-Verlag, Berlin Heidelberg. ISBN: 978-3-642-63923. Details
(2003) Unified framework for numerical methods to solve the time-dependent Maxwell equations. Computer Physics Communication 156, 43-61. Details PDF
(2003) Chebyshev method to solve the time-dependent Maxwell equations. In: Computer simulation studies in condensed-matter physics XV, pp. 211-215.Springer-Verlag Berlin Heidelberg. Details
(2003) One-step finite-difference time-domain algorithm to solve the Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 67(5 Pt 2), 056706. Details PubMed
(2003) Solving the Maxwell equations by the Chebyshev method: a one-step finite-difference time-domain algorithm. IEEE Transactions on Antennas and Propagation 51, 3155-3160. Details PDF
(2003) Molecular dynamics simulation of dislocation dynamics during nanoindentation. In: Advances in Computational & Experimental Engeneering & Sciences International Conference ICCES 2003, Tech Science Press. Details
(2003) Solving the time-dependent Maxwell equations by unconditionally stable algorithms. In: Computer simulation studies in condensed-matter physics XV pp. 205-210.Springer-Verlag Berlin Heidelberg. Details
(2002) Statistical model for receptor-ligand binding thermodynamics. Phys Rev E Stat Nonlin Soft Matter Phys 66(6 Pt 1), 061901. Details PubMed
(2002) Peierls instability due to the interaction of electrons with both acoustic and optical phonons in metallic carbon nanotubes. Physical Review B 65(12), 125416. Details
(2002) New unconditionally stable algorithms to solve the time-dependent Maxwell equations. Springer Verlag Lecture Notes in Computer Science (LNCS) 2329, 803. Details
(2002) Higher-order unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 65(6 Pt 2), 066705. Details PubMed
(2001) Peierls transition with acoustic phonons and solitwistons in carbon nanotubes. Phys Rev Lett 86(20), 4572-4575. Details PubMed
(2001) Unconditionally stable algorithms to solve the time-dependent Maxwell equations. Phys Rev E Stat Nonlin Soft Matter Phys 64(6 Pt 2), 066705. Details PubMed
(2000) Disorder and interchain interactions in Peierls systems. In: PhD thesis, University of Groningen. ISBN: ISBN 90-367-127. Details PDF
(1999) Disorder-induced neutral solitons in degenerate ground state polymers. Synthetic Metals 101(1-3), 388-389. Details
(1999) Magnetic susceptibility due to disorder-induced neutral solitons in interacting polymer chains. Physical Review B 59(21), 13882-13891. Details Open Access PDF
(1998) Density of neutral solitons in weakly disordered Peierls chains. Physical Review B 57(5), 2861-2871. Details Open Access PDF
(1998) Critical temperature and density of spin flips in the anisotropic random-field Ising model. Physical Review B 58(5), 2626-2634. Details Open Access PDF
(1997) Disorder-induced solitons in conjugated polymers. Europhysics Letters 38(9), 687-692. Details