
Dr. Pierre Stallforth
Paleobiotechnology · Head
Phone: +49 3641 532-1527 Fax: +49 3641 532-2527 Email: pierre.stallforth@leibniz-hki.de
- Natural products from prehistoric samples
- Natural products from microbial interactions (microbial predator-prey associations, amoebae-bacteria interactions)
- Structure elucidation and biosynthetic studies
Professional Career
2020 | Head of the Department Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology, (Hans-Knöll-Institute, Jena) |
2019 - 2020 | Interim Professorship Organic Chemistry University of Hamburg |
2013 - 2019 | Junior research group leader, Leibniz Institute for Natural Product Research and Infection Biology, (Hans-Knöll-Institute, Jena) |
2011-2013 | Postdoc, Harvard Medical School, Dept. of Biological Chemistry and Molecular Pharmacology, Boston, Supervisor: Prof. Jon Clardy |
2006-2010 | Graduate studies (Dr. sc. ETH Zurich), ETH Zurich and Max Planck Institute, colloids and interfaces, biomolecular systems, Berlin supervisors: Prof. Peter H. Seeberger “synthesis of bacterial carbohydrates and glycolipids for application in novel vaccine srategies” |
2002-2006 | MSc studies chemistry, St Edmund Hall, University of Oxford (1st class, being placed 2nd out of 150 students) Master thesis, University of Oxford “dynamics of a quantum dot in a magnetic field” (1st class) |
2002 | Abitur (A-levels) at the Paul-Klee-Gymnasium Gersthofen, Germany |
Awards · Appointments · Scientific Activities
2020 | Academy of Sciences Göttingen, Academy Prize for Chemistry |
2019 | DECHEMA Research Award Natural Product Research |
2018 | Medac Research Award |
2018 | Best Talk Prize, Bioorganic Symposium, Bochum 2018 |
2018 | Max Buchner Stipend, DECHEMA |
2017 | Prize for the Best Talk (2017 Dicty Meeting) |
2016 | Medac Research Award |
2014 | Fellowship of the Daimler and Benz Foundation |
2012 | Feodor Lynen-postdoc fellowship (Humboldt Foundation) |
2011 | Swiss National Fund Postdoc fellowship |
2007 | PhD fellowship, Studienstiftung des deutschen Volkes (German Academic Merit Foundation) |
2005 | Gibbs prize for excellence in the final examination |
2005-2007 | Fellowship of the Studienstiftung des deutschen Volkes |
2003 and 2004 | Turbutt prize for excellence in practical organic chemistry |
2003-2006 | University of Oxford, open scholarship |
2002 | Prize for the best Abitur (A-levels) at the Paul-Klee-Gymnaisum |
(2021) The landscape of recombination events that greate nonribosomal peptide diversity. Mol Biol Evol [Epub ahead of print] Details PubMed
(2021) Chimeric LuxR transcription factors rewire natural product regulation. Angew Chem Int Ed 59(15), 6192-6195. Details PubMed Open Access PDF
(2021) Lipopeptide-mediated Bacterial Interaction Enables Cooperative Predator Defense. Proc Natl Acad Sci USA 118(6), e2013759118. Details PubMed Open Access PDF
(2020) Structure elucidation of bacterial nonribosomal lipopeptides. Org Biomol Chem 18(9), 1710-1727. (Review) Details PubMed
(2020) Structure, properties, and biological functions of nonribosomal lipopeptides from pseudomonads. Nat Prod Rep 37(1), 29-54. (Review) Details PubMed Open Access PDF
(2020) Biosynthesis of pseudomonas-derived butenolides. Angew Chem Int Ed 59(14), 5607-5610. Details PubMed Open Access PDF
(2020) Special issue in honor of Professor Jon Clardy. J Nat Prod 83(3), 565-568. (Review) Details PubMed Open Access PDF
(2020) Cellular microbiology interview ‐ Dr. Pierre Stallforth. Cell Microbiol 22(5), e13188. (Review) Details PubMed
(2019) Disruption of membrane integrity by the bacteria-derived antifungal jagaricin. Antimicrob Agents Chemother 63(9), e00707-19. Details PubMed Open Access PDF
(2019) Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases. Chem Sci 10(48), 10979-10990. Details Open Access PDF
(2019) Chemical Ecology of Dictyostelium discoideum. In: Comprehensive Natural Products III Elsevier. (Review) Details
(2019) Bioactivity and mode of action of bacterial tetramic acids. ACS Chem Biol 14(8), 1693-1697. Details PubMed
(2019) Solid-phase-based total synthesis and stereochemical assignment of the cryptic natural product aurantizolicin. Org Lett 21(3), 729-732. Details PubMed
(2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763. Details PubMed Open Access
(2018) Natural products from social amoebae. Chem Eur J 24(17), 4202-4214. (Review) Details PubMed
(2018) Synthesis, liposomal formulation, and immunological evaluation of a minimalistic carbohydrate-α-galCer vaccine candidate. J Med Chem 61(11), 4918-4927. Details PubMed
(2018) The chemoattractant glorin is inactivated by ester cleavage during multicellular development of the social amoeba Polysphondylium pallidum. ACS Chem Biol 13(6), 1506-1513. Details PubMed
(2018) The role of bacterial natural products in predator defense. Synlett 29(5), 537-541. (Review) Details
(2018) Bacterial alkaloid biosynthesis: Structural diversity via a minimalistic nonribosomal peptide synthetase. Cell Chem Biol 25(6), 659-665. Details PubMed Open Access
(2017) Rationalizing the Right Ratios. Cell Chem Biol 24(5), 539-541. (Review) Details PubMed
(2017) Versatile synthesis of the signaling peptide glorin Beilstein J Org Chem 13, 247-250. Details
(2017) Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine. J Bacteriol 199(22), e00204-e00217. Details PubMed
(2017) Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin ACS Chem Biol 12(10), 2498-2502. Details PubMed
(2016) Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland. ACS Chem Biol 11(4), 816-820. (Review) Details PubMed
(2016) Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed 55(31), 8944-8947. Details PubMed Supplement
(2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutus. Chem Biol 22, 1325-1334. Details PubMed
(2015) Total Synthesis of Legionaminic Acid as Basis for Serological Studies J Am Chem Soc 137, 2848-2851. Details
(2014) A semi-synthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice Nat Chem Biol 10, 950-956. Details
(2014) Atlas for drug discovery. Proc Natl Acad Sci U S A 111(10), 3655-3656. Details PubMed
(2013) A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A 110(36), 14528-14533. Details PubMed
(2013) X-ray crystallography: One size fits most. Nature 495(7442), 456-457. Details PubMed
(2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687. Details PubMed
(2010) Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block. Chem Commun (Camb) 46(23), 4106-4108. Details PubMed
(2010) De novo synthesis of a 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block for the preparation of a Bacteroides fragilis A1 polysaccharide fragment. Org Lett 12(7), 1624-1627. Details PubMed
(2008) De novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae. Org Lett 10(8), 1573-1576. Details PubMed