Pierre Stallforth

Dr. Pierre Stallforth

Chemistry of Microbial Communication · Head

Phone: +49 3641 532-1527 Fax: +49 3641 532-2527 Email: pierre.stallforth@leibniz-hki.de

Main Research Areas
  • Chemical ecology of the amobae-bacteria symbiosis
  • Prokaryotic and eukaryotic signal molecules
  • Structure elucidation and biosynthetic studies
Curriculum vitae

Professional Career

12/2013 Junior research group leader, Leibniz Institute for Natural Product Research and Infection Biology, (Hans-Knöll-Institute, Jena) 
2/2011-11/2013 Postdoc, Harvard Medical School, Dept. of Biological Chemistry and Molecular Pharmacology, Boston, Supervisor: Prof. Jon Clardy
11/2006-11/2010 Graduate studies (Dr. sc. ETH Zurich), ETH Zurich and Max Planck Institute, colloids and interfaces, biomolecular systems, Berlin supervisors: Prof. Peter H. Seeberger, Prof. Donald Hilvert “synthesis of bacterial carbohydrates and glycolipids for application in novel vaccine srategies”
09/2005-07/2006 Master thesis, University of Oxford supervisor: Prof. David E. Logan “dynamics of a quantum dot in a magnetic field” (1st class)
10/2002-07/2006 MSc studies chemistry, St Edmund Hall, University of Oxford (1st class, being placed 2nd out of 150 students)
06/2002 Abitur (A-levels) at the Paul-Klee-Gymnasium Gersthofen, Germany

Awards · Appointments · Scientific Activities

2017 Prize for the Best Talk (2017 Dicty Meeting)
2016 Medac Research Prize
2014  Fellowship of the Daimler and Benz Foundation
2012 Feodor Lynen-postdoc fellowship (Humboldt Foundation)
2011 Swiss National Fund Postdoc fellowship
2007 PhD fellowship, Studienstiftung des deutschen Volkes (German Academic Merit Foundation)
2005 Gibbs prize for excellence in the final examination
2005-2007 Fellowship of the Studienstiftung des deutschen Volkes
2003 and 2004 Turbutt prize for excellence in practical organic chemistry
2003-2006 University of Oxford, open scholarship
2002 Prize for the best Abitur (A-levels) at the Paul-Klee-Gymnaisum
Publications

Oberheide A, Pflanze S, Stallforth P, Arndt H-D (2019) Solid-Phase-Based Total Synthesis and Stereochemical Assignment of the Cryptic Natural Product Aurantizolicin Org Lett [Epub ahead of print] Details

Arp J, Götze S, Mukherji R, Mattern DJ, Garcia-Altares M, Klapper M, Brock DA, Brakhage AA, Strassmann JE, Queller DC, Bardl B, Willing K, Peschel G, Stallforth P (2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria Proc Natl Acad Sci USA 115, 3758-3763. Details PubMed

Broecker F, Götze S, Hudon J, Rathwell DCK, Pereira CL, Stallforth P, Anish C, Seeberger PH (2018) Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate J Med Chem 61(11), 4918-4927. Details PubMed

Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T (2018) The chemoattractant glorin is inactivated by ester cleavage during multicellular development of the social amoeba Polysphondylium pallidum ACS Chem Biol 13(6), 1506-1513. Details PubMed

Klapper M, Arp J, Günther M, Stallforth P (2018) The Role of Bacterial Natural Products in Predator Defense Synlett 29, 537. (Review) Details

Klapper M, Braga D, Lackner G, Herbst R, Stallforth P (2018) Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase Cell Chem Biol 25(6), 659-665. Details

Arp J, Stallforth P (2017) Rationalizing the Right Ratios. Cell Chem Biol 24(5), 539-541. (Review) Details PubMed

Barnett R, Raszkowski D, Winckler T, Stallforth P (2017) Versatile synthesis of the signaling peptide glorin Beilstein J Org Chem 13, 247-250. Details

Barnett R, Stallforth, P (2017) Natural Products from Social Amoebae Chem Eur J 24(17), 4202-4214. (Review) Details PubMed

Gallegos-Monterrosa R, Kankel S, Götze S, Barnett R, Stallforth P, Kovács ÁT (2017) Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine. J Bacteriol 199(22), e00204-e00217. Details PubMed

Götze S, Herbst-Irmer R, Klapper M, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, Stallforth P (2017) Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin ACS Chem Biol 12(10), 2498-2502. Details PubMed

Adibekian A, Stallforth P (2016) Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13-15, Geneva, Switzerland. ACS Chem Biol 11(4), 816-820. (Review) Details PubMed

Klapper M, Götze S, Barnett R, Willing K, Stallforth P (2016) Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed 55(31), 8944-8947. Details PubMed Supplement

Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D (2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutus. Chem Biol 22, 1325-1334. Details PubMed

Matthies S, Stallforth P, Seeberger PH (2015) Total Synthesis of Legionaminic Acid as Basis for Serological Studies J Am Chem Soc 137, 2848-2851. Details

Cavallari M, Stallforth P, Kalinichenko A, Rathwell DCK, Gronewold TMA, Adibekian A, Mori L, Landmann R, Seeberger PH, DeLibero G (2014) A semi-synthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice Nat Chem Biol 10, 950-956. Details

Stallforth P, Clardy J (2014) Atlas for drug discovery. Proc Natl Acad Sci U S A 111(10), 3655-3656. Details PubMed

Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy J (2013) A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A 110(36), 14528-14533. Details PubMed

Stallforth P, Clardy J (2013) X-ray crystallography: One size fits most. Nature 495(7442), 456-457. Details PubMed

Stallforth P, Clardy J (2012) Protein evolution: when two become three. Curr Biol 22(17), R685-R687. Details PubMed

Ohara T, Adibekian A, Esposito D, Stallforth P, Seeberger PH (2010) Towards the synthesis of a Yersinia pestis cell wall polysaccharide: enantioselective synthesis of an L-glycero-D-manno-heptose building block. Chem Commun (Camb) 46(23), 4106-4108. Details PubMed

Pragani R, Stallforth P, Seeberger PH (2010) De novo synthesis of a 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block for the preparation of a Bacteroides fragilis A1 polysaccharide fragment. Org Lett 12(7), 1624-1627. Details PubMed

Stallforth P, Adibekian A, Seeberger PH (2008) De novo synthesis of a D-galacturonic acid thioglycoside as key to the total synthesis of a glycosphingolipid from Sphingomonas yanoikuyae. Org Lett 10(8), 1573-1576. Details PubMed

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