Gianni Panagiotou

Assoc. Prof. Dr. Gianni Panagiotou

Systems Biology and Bioinformatics · Head

Phone: +49 3641 532-1759 Fax: +49 3641 532-2759 Email: gianni.panagiotou@leibniz-hki.de

Main Research Areas
  • Medical & Environmental Metagenomics: human, mice, marine, plants;
  • Systems Biology: -omics integration, chemical-protein & protein-protein interaction networks, genome-scale metabolic modelling; 
  • Metabolic Engineering: yeast cell factory
Curriculum vitae

Professional Career

EDUCATION

2000-2004 PhD in metabolic engineering obtained from the National Technical University of Athens (16 months as guest PhD at the Technical University of Denmark).
1993-1999 Diploma (BSc & MSc) in chemical engineering obtained from the National Technical University of Athens, Greece

EMPLOYMENT AND ACADEMIC AFFILIATIONS

2017- Head of Systems Biology & Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany.
2013-2017 Associate Professor at the Faculty of Science, School of Biological Sciences, The University of Hong Kong.
The University of Hong Kong places 25th in 2019 QS World University Rankings
2009-2013 Associate Professor at the Department of Systems Biology, Technical University of Denmark. 
The Technical University of Denmark places 112th in 2019 QS World University Rankings
2007-2009 Assistant Professor at the Department of Systems Biology, Technical University of Denmark.
2004-2007 Post-doctoral researcher at the Department of Systems Biology, Technical University of Denmark.

2018-2020 (Honorary) Associate Professor at the Department of Microbiology at Li Ka Shing Faculty of Medicine, The University of Hong Kong.
2017-2020 (Honorary) Associate Professor at the Faculty of Science, School of Biological Sciences, The University of Hong Kong.

EXTERNAL STAYS

2010      Visiting Assoc. Professor at the Industrial Biotechnology lab, Department of Chemical and Biological Engineering, Chalmers University, Sweden (January – May)
2008 Visiting Assist. Professor at the Natural Products Chemistry Lab, Department of Pharmaceutical Sciences, The University of Tokyo, Japan (January – December)

Awards · Appointments · Scientific Activities

MANAGEMENT AND TEACHING EXPERIENCE

2019     Organizer of the Training School “Next Generation Data Analysis” offered to the 15 PhD students of the Innovative Training Network “BestTreat”, at Hans Knoell Institute, Jena, Germany, August 28-31 (15 participants).
2019 Organizer of the workshop “RNA Sequencing Processing and Data Analysis” at Hans Knoell Institute, Jena, Germany, April 10-11 (15 participants).
2019 Organizer of the 4th International Symposium on Systems Biology of Microbial Infection in Jena, Germany, September 26-27.
2018 Lecturer at NUGO: 5th Nutrition Winter School, “Breaking barriers: Gut, Brain Bugs – and Beyond”, Levi, Finland, January 21-26.
2017 Organizer of the 4th International Symposium on Systems Biology of Microbial Infection in Jena, Germany, September 21-22.
2016 Organizer of the International “Next Generation Sequencing Data Analysis” workshop at The University of Hong Kong, Hong Kong, 15th-21st of May (50 participants).
2016 Member of the Scientific Committee of the BBW2016: Frontiers in Human Microbiota Symbiotic Interactions, Organized by Fondation IPSEN and AAAS/Science and Science Translational Medicine, Hong Kong May 23-25, 2016.
2015 Organizer of the International “Next Generation Sequencing Data Analysis” workshop at The University of Hong Kong, Hong Kong, 27th-31st of May (30 participants) and 3rd-7th of June (30 participants).
2014-2016 Responsible for the development and teaching of the course #BIOL2102 “Biostatistics” (on average 250-300 students), The University of Hong Kong (details in the Teaching Portfolio).
2014-2016 Responsible for the development and teaching (50%) of the course #BIOL3307/3409 “Business Aspects of Biotechnology” (on average 30-40 students), The University of Hong Kong (details in the Teaching Portfolio).
2014 Organizer of the workshop “Analysis of transcriptome data-turbo version” for the students enrolled in the course #BIOL2102, The University of Hong Kong (June-August, 15 participants).
2013-2016 Course Coordinator of the course #BIOL6001 “Presentation Skills and Research Seminars in Biological Sciences”, The University of Hong Kong.
2013-2016 Course Selection Adviser (CSA) for the Biotechnology Major (3-year curriculum), The University of Hong Kong.
2005-2007 Group coordinator at the research cluster “Engineering of the Central Carbon Metabolism”, in the Centre for Microbial Biotechnology, Technical University of Denmark.


STUDENT SUPERVISION EXPERIENCE AS MAIN SUPERVISOR

Sara Leal, PhD 2019-2022 Humans as holobionts: systems level approaches for disease prevention and therapy | Hans Knoell Institute, Germany
Manos Nychas, PhD 2019-2022 Bioinformatics analysis of meta-omics datasets from human subjects and mice models | Hans Knoell Institute, Germany
Howell Leung, PhD 2019-2022 Metagenome mining for effective design of ecology-based treatments | Hans Knoell Institute, Germany
Albert Garcia, PhD 2019-2022 Systems Biology and Machine learning in Host-Pathogen Interactions | Hans Knoell Institute, Germany
Mohammadhassan Mirhakkak Esfahani, PhD 2017-2020 Integration of host, pathogen and microbiome -omics data in healthy and disease states | Hans Knoell Institute, Germany
Daniel Loos, PhD 2018-2021 Linking diseases with the human gut microbiome – biomarker discovery in multi meta-omics data | Hans Knoell Institute, Germany
Bastian Seelbinder, PhD 2018-2021 High-throughput sequencing data analysis for understanding host-pathogen interactions | Hans Knoell Institute, Germany
Tongta Sae-Ong, PhD 2018-2021 Systems level analysis to elucidate the interplay of host-microbiome in critical illness | Hans Knoell Institute, Germany
Jiarui Chen, PhD 2016-2020 Elucidating the complex interactions of microbial communities using high-throughput data integration | The University of Hong Kong, Hong Kong
Yoshitaro Heshiki, PhD 2015-2019 Studying microbial communities through next generation sequencing | The University of Hong Kong, Hong Kong
Tingting Zheng, PhD 2015-2019 A systems biology approach for studying human diseases | The University of Hong Kong, Hong Kong
Samuel Kang, PhD 2014-2018 Bioinformatic Approaches for Exploring the Genetic and Compositional Diversities of Human-Associated Microbial Worlds | The University of Hong Kong, Hong Kong
Yueqiong Ni, PhD 2013-2017 Integrative analysis of the human genome, metagenome and exposome | The University of Hong Kong, Hong Kong
Kasper Jensen, PhD 2011-2014 Nutritional Systems Biology | Technical University of Denmark, Denmark (joint supervision with Prof. Kouskoumvekaki)
Gupta Udatha, PhD 2009-2013 Towards Classification and Functional Description of Enzymes: A case study of Feruloyl Esterases | Chalmers University of Technology, Sweden (joint supervision with Prof. Olsson)
              
2002-2019                
Supervisor of seventeen BSc and MSc students, fourteen internships and one research assistant at National Technical University of Athens, Greece, Technical University of Denmark, Denmark, The University of Hong Kong, Hong Kong, and Hans Knoell Institute, Germany

MENTORING
Jun Li 2013-2018 Post-Doctoral Researcher, The University of Hong, Hong Kong & Hans Knoell Institute | Currently Assistant Professor at the City University of Hong
Yueqiong Ni 2018-2020 Post-Doctoral Researcher, Hans Knoell Institute, Germany
Kang Kang 2018-2019 Post-Doctoral Researcher, Hans Knoell Institute, Germany
Thomas Wolf 2018-2019 Post-Doctoral Researcher, Hans Knoell Institute, Germany
Rakesh Santhanam 2018-2020 Post-Doctoral Researcher, Hans Knoell Institute, Germany
Sascha Schäuble 2018-2020 Post-Doctoral Researcher, Hans Knoell Institute, Germany
Wolfgang Schmidt-Heck 2018-2020 Scientific Co-worker, Hans Knoell Institute, Germany
Peter Großman 2018-2020 Scientific Co-worker, Hans Knoell Institute, Germany
                                                    

RESEARCH GRANTS
2018 co-I Area of Excellence of the Hong Kong Research Grants Council, “Institute of Metabolic Medicine”, Hong Kong 77,000,000 HKD
2018 co-I Excellence Strategy of the Federal Government “Balance of the Microverse”, Deutsche Forschungsgemeinschaft (DFG), Germany 38,000,000 EURO
2018 PI BestTreat “Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Non-Alcoholic Fatty Liver Disease”, Horizon 2020-MSCA-ITN-ETN 4,100,000 EURO
2017 co-I CRC/Transregio 124 “Pathogenic fungi and their human host: Networks of interaction”, Deutsche Forschungsgemeinschaft (DFG), Germany 8,200,000 EURO
2016 co-I “Detection of HIV-1 minority drug-resistant and X4-tropic variants by Next-Generation Sequencing to improve the prediction of clinical antiretroviral treatment outcome”, AIDS Trust Fund, MSS 248 R, Hong Kong 2,597,960 HKD
2016 co-I Environment and Conservation Fund (Hong Kong), MarineGEO - Hong Kong, “Towards an understanding of marine biodiversity and ecosystem function”, 67/2016, Hong Kong 3,200,000 HKD
2014 PI co-funding from the Faculties of Science and Architecture for the project “How bacteria travel around Hong Kong: A metagenome-based mapping of the transportation system”, Hong Kong 400,000 HKD
2014-2015 PI funding from the HKU Strategic Research Theme for Clean Energy for the project “Integration of Yeast Systems Biology into Biorefineries”, Hong Kong 354,000 HKD
2014-2015 PI funding from the HKU Strategic Research Theme of Genomics for the project “Uncovering the complex interactions between anticancer drugs and gut-associated syntrophic consortia using integrated metagenomic sequence analysis”, Hong Kong 225,000 HKD
2014 PI funding from the HKU Seed Funding for Applied Research Scheme, for the project “Designing a 3-hydroxy-propionic acid yeast cell factory using systems & synthetic biology approaches”, Hong Kong 96,000 HKD
2014 PI funding from the HKU Seed Funding for Basic Research Scheme, for the project “Correlation of gut microbiota composition with diet and atherosclerosis development”, Hong Kong 46,000 HKD
2013 PI funding from the HKU University Research Committee in the 30th Round: Post-doctoral Fellow/Research Assistant Professor Scheme, Hong Kong 336,000 HKD
2013 PI funding from the HKU Seed Funding for Basic Research Scheme, for the project “Studying the antibiotic gut resistome and the collateral effects of antibiotics on gut microbes using massive sequencing”, Hong Kong 120,000 HKD
2010 PI funding from the Wallenberg Foundation, Sweden, for designing a microarray chip for the enzyme producer A. oryzae, Sweden 116,000 DKK
2007 PI funding from the Danish Research Council for Technology and Production Sciences, for the project ´´Biotransformation of agro-industrial residues to antibiotics by combinatorial protein chemistry and metabolic engineering´´, Denmark 2,077,500 DKK
2007 PI funding from the Lundbeck Foundation, for the project ´´Use of cDNA microarrays of the filamentous fungus Aspergillus nidulans´´, Denmark 89,371 DKK
2006 funding from the Villum Kann Rasmussen Foundation for the project ´´Aspergillus as an efficient cell factory for production of polyketides – metabolic engineering strategies for efficient production of the Acetyl-CoA precursor molecule´´, Denmark 832,818 DKK
                          


EVIDENCE OF ESTEEM; EXTERNAL VISIBILITY AND PROFESSIONAL ACTIVITIES
MEMBER URC Working Group on Entrepreneurship Development under the University Research Committee, The University of Hong Kong (nominated by the Dean for representing the Faculty of Science), 2014 – 2017.
 
Science Faculty Information Technology Committee, The University of Hong Kong (HKU), 2014 - 2017.
 
Career Advisory Board, The University of Hong Kong (HKU), 2015 - 2017.
 
Strategic Research Theme of Genomics (HKU), 2013 - 2017; Strategic Research Theme for Clean Energy (HKU), 2013 - 2017; Strategic Research Theme of Integrative Biology (HKU), 2014.
     
EDITORIAL WORK Editor-in-Chief: Computational and Structural Biotechnology Journal (2018 Impact Factor of 4.2, Elsevier), 2002-2019.
 
Guest Editor for the research topic “Systems Biology of Metabolism in Infection” for Frontiers in Cellular and Infection Microbiology, 2019
  
Ad hoc reviewer: Briefings in Bioinformatics; Bioinformatics; Cell Reports; Microbial Cell Factories, Scientific Reports etc
  
PEER EVALUATION Electoral Committee: Member of the Electoral Committee, Researcher C, “Bioinformatics or Computational Biology’’, Institute of Computer Sciences of the Foundation for Research and Technology-Hellas 2013.
  
Electoral Committee: Member of the Electoral committee for the W3 Professorship for Genomics and Bioinformatics in Horticultural Sciences, at the Faculty of Science of the University of Potsdam, 2019.
  
Examiner: 5 PhD and 1 MSc thesis submitted at the School of Biological Sciences, Faculty of Science, The University of Hong Kong and 1 PhD thesis submitted at the Friedrich Schiller University, Jena, Germany.
  
AWARDS Research Output Prize 2017 in the Faculty of Science, The University of Hong Kong, for the article “Probiotics Modulated Gut Microbiota Suppresses Hepatocellular Carcinoma Growth in Mice”.
   
MEDIA My research has been featured in articles of South China Morning Post (Asia), Spiegel, Bild, Daily Mail (Europe), LA Times (US), among many others.
   
PATENTS WO2009144245-A1 Gianni Panagiotou, Jens Nielsen, Lisbeth Olsson. 2008. “New recombinant filamentous fungal host cell having NADH kinase activity compared to identical wild type host cell, useful for production of a polypeptide of interest useful for increasing growth rate” (Novozymes has acquired the Patent Rights)
   
EP2062967-A1 Gianni Panagiotou, Torsten B. Regueira, Jens Nielsen, Lisbeth Olsson. 2008. ´´New genetically engineered Aspergillus overexpressing phosphoketolase useful for production of recombinant polypeptide´´
Publications

Kang K, Bergdahl B, Machado D, Dato L, Han TL, Li J, Villas-Boas S, Herrgård MJ, Förster J, Panagiotou G** (2019) Linking genetic, metabolic and phenotypic diversity among S. cerevisiae strains using multi-omics associations GigaScience [Epub ahead of print] Details Open Access

Zheng T, Li Y, Ni Y, Kang K, Misiakou MA, Imamovic L, Chow BKC, Rode AA, Bytzer P, Sommer M, Panagiotou G** (2019) Mining, Analyzing and Integrating Viral Signals from Metagenomic Data Microbiome [Accepted] Details

Gill H, Ip HW, Yim R, Tang WF, Pang HH, Lee P, Leung GMK, Li J, Tang K, So JCC, Leung RYY, Li J, Panagioutou G, Lam CCK, Kwong YL (2018) Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis. Ann Hematol [Epub ahead of print] Details PubMed

Imamovic L, Misiakou MA, van der Helm E, Panagiotou G, Muniesa M, Sommer MOA (2018) Complete Genome Sequence of Escherichia coli Strain WG5. Genome Announc 6(2), pii: e01403-pii: e01417. Details PubMed

Kang K, Ni Y, Li J, Imamovic L, Sarkar C, Kobler MD, Heshiki Y, Zheng T, Kumari S, Wong JCY, Archna A, Wong CWM, Dingle C, Denizen S, Baker DM, Sommer MOA, Webster CJ, Panagiotou G** (2018) The Environmental Exposures and Inner- and Intercity Traffic Flows of the Metro System May Contribute to the Human Skin Microbiome and Resistome Cell Reports 24(5), 1190-1202. Details PubMed Open Access

Lau SKP, Teng JLL, Chiu TH, Chan E, Tsang AKL, Panagiotou G, Zhai SL, Woo PCY (2018) Differential Microbial Communities of Omnivorous and Herbivorous Cattle in Southern China Comput Struct Biotechnol J 16, 54-60. Details PubMed Open Access

Li J, Rettedal EA, van der Helm E, Ellabaan M, Panagiotou G**, Sommer MOA (2018) Antibiotic Treatment Drives the Diversification of the Human Gut Resistome Genomics, Proteomics & Bioinformatics [Epub ahead of print] Details Open Access

Zhang L, Ouyang Y, Li H, Shen L, Ni Y, Fang Q, Wu G, Qian L, Xiao Y, Zhang J, Yin P, Panagiotou G, Xu G, Ye J, Jia W (2018) Metabolic phenotypes and gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial Scientific Reports [Accepted] Details

Heshiki Y, Dissanayake T, Zheng T, Kang K, Yueqiong N, Xu Z, Sarkar C, Woo PCY, Chow BKC, Baker D, Yan A, Webster CJ, Panagiotou G**, Li J** (2017) Toward a Metagenomic Understanding on the Bacterial Composition and Resistome in Hong Kong Banknotes Front Microbiol 8(632), Details PubMed Open Access

Ni Y, Jensen K, Kouskoumvekaki I**, Panagiotou G** (2017) NutriChem 2.0: exploring the effect of plant-based foods on human health and drug efficacy Database (2017), Details PubMed Open Access

Ni Y, Wong VHY, Tai WCS, Li J, Wong WY, Lee MML, Fong FLY, El-Nezami H**, Panagiotou G** (2017) A metagenomic study of the preventive effect of Lactobacillus rhamnosus GG on intestinal polyp formation in ApcMin/+ mice J Appl Microbiol 122(3), 770-784. Details PubMed

Zheng T, Ni Y, Li J, Chow BKC, Panagiotou G** (2017) Designing Dietary Recommendations Using System Level Interactomics Analysis and Network-Based Inference Front Physiol 8, 753. Details PubMed Open Access

Li J, Sung CY, Lee N, Ni Y, Pihlajamäki J, Panagiotou G, El-Nezami H (2016) Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. Proc Natl Acad Sci U S A 113(9), E1306-E1315. Details PubMed

Liang C, Cheng S, Zhang Y, Sun Y, Fernie AR, Kang K, Panagiotou G, Lo C, Lim BL (2016) Transcriptomic, proteomic and metabolic changes in Arabidopsis thaliana leaves after the onset of illumination. BMC Plant Biol 16, 43. Details PubMed

Ni Y, Li J, Panagiotou G (2016) COMAN: a web server for comprehensive metatranscriptomics analysis. BMC Genomics 17(1), 622. Details PubMed

Jensen K, Ni Y, Panagiotou G, Kouskoumvekaki I (2015) Developing a molecular roadmap of drug-food interactions. PLOS Comput Biol 11(2), e1004048. Details PubMed

Jensen K, Panagiotou G, Kouskoumvekaki I (2015) NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods. Nucleic Acids Res 43(Database issue), D940-D945. Details PubMed

Kang K, Li J, Lim BL, Panagiotou G (2015) MESSI: metabolic engineering target selection and best strain identification tool. Database (Oxford) 2015, Details PubMed

Ni Y, Li J, Panagiotou G (2015) A Molecular-Level Landscape of Diet-Gut Microbiome Interactions: Toward Dietary Interventions Targeting Bacterial Genes. MBio 6(6), e01263. Details PubMed

Udatha DB, Madsen KM, Panagiotou G, Olsson L (2015) Multiple nucleophilic elbows leading to multiple active sites in a single module esterase from Sorangium cellulosum. J Struct Biol 190(3), 314-327. Details PubMed

Udatha DB, Topakas E, Salazar M, Olsson L, Andersen MR, Panagiotou G (2015) Deciphering the signaling mechanisms of the plant cell wall degradation machinery in Aspergillus oryzae. BMC Syst Biol 9, 77. Details PubMed

Jensen K, Panagiotou G, Kouskoumvekaki I (2014) Integrated text mining and chemoinformatics analysis associates diet to health benefit at molecular level. PLOS Comput Biol 10(1), e1003432. Details PubMed

Westergaard D, Li J, Jensen K, Kouskoumvekaki I, Panagiotou G (2014) Exploring mechanisms of diet-colon cancer associations through candidate molecular interaction networks. BMC Genomics 15, 380. Details PubMed

Jacobsen UP, Nielsen HB, Hildebrand F, Raes J, Sicheritz-Ponten T, Kouskoumvekaki I, Panagiotou G (2013) The chemical interactome space between the human host and the genetically defined gut metabotypes. ISME J 7(4), 730-742. Details PubMed

Topakas E, Panagiotou G, Christakopoulos P (2013) Characteristics, sources, production and applications. Xylanases. In: Yang S-T, El Ensashy H, Thongchul N (eds.) Bioprocessing Technologies in Biorefinery for Sustainable Production of Fuels, Chemicals, and Polymers pp. 147-169. Wiley. ISBN: 978-0-470-54195. Details

Udatha DB, Rasmussen S, Sicheritz-Pontén T, Panagiotou G (2013) Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs). Methods Mol Biol 985, 409-428. Details PubMed

Herrgård M, Panagiotou G (2012) Analyzing the genomic variation of microbial cell factories in the era of "New Biotechnology" Comput Struct Biotechnol J 3, e201210012. Details PubMed

Jensen K, Plichta D, Panagiotou G, Kouskoumvekaki I (2012) Mapping the genome of Plasmodium falciparum on the drug-like chemical space reveals novel anti-malarial targets and potential drug leads. Mol Biosyst 8(6), 1678-1685. Details PubMed

Panagiotou G, Taboureau O (2012) The impact of network biology in pharmacology and toxicology. SAR QSAR Environ Res 23(3-4), 221-235. (Review) Details PubMed

Udatha DB, Mapelli V, Panagiotou G, Olsson L (2012) Common and distant structural characteristics of feruloyl esterase families from Aspergillus oryzae. PLOS One 7(6), e39473. Details PubMed

Udatha DB, Sugaya N, Olsson L, Panagiotou G (2012) How well do the substrates KISS the enzyme? Molecular docking program selection for feruloyl esterases. Sci Rep 2, 323. Details PubMed

Kouskoumvekaki I, Panagiotou G (2011) Navigating the human metabolome for biomarker identification and design of pharmaceutical molecules. J Biomed Biotechnol 2011, Details PubMed

Madsen KM, Udatha GD, Semba S, Otero JM, Koetter P, Nielsen J, Ebizuka Y, Kushiro T, Panagiotou G (2011) Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. PLOS One 6(3), e14763. Details PubMed

Panagiotou G, Topakas E, Moukouli M, Christakopoulos P, Olsson L (2011) Studying the ability of Fusarium oxysporum and recombinant Saccharomyces cerevisae to efficiently cooperate in decomposition and ethanolic fermentation of wheat straw. Biomass and Bioenergy 35(8), 3727-3732. Details

Udatha DB, Kouskoumvekaki I, Olsson L, Panagiotou G (2011) The interplay of descriptor-based computational analysis with pharmacophore modeling builds the basis for a novel classification scheme for feruloyl esterases. Biotechnol Adv 29(1), 94-9110. Details PubMed

Olivares-Hernández R, Sunner H, Frisvad JC, Olsson L, Nielsen J, Panagiotou G (2010) Combining substrate specificity analysis with support vector classifiers reveals feruloyl esterase as a phylogenetically informative protein group. PLOS One 5(9), e12781. Details PubMed

Otero JM, Papadakis MA, Udatha DB, Nielsen J, Panagiotou G (2010) Yeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress response. PLOS One 5(10), e13606. Details PubMed

Panagiotou G, Topakas E, Olivares R, Christakopoulos P, Olsson L (2010) Feruloyl esterases as biosynthetic tools for the organic synthesis of nutraceutical compounds In: Heldman DR, Hoover DG, Wheeler MB (eds.) Encyclopedia of Biotechnology in Agriculture and Food CRC Press, Boca Raton, FL, USA. ISBN: 978-0849350276. Details

Panagiotou G, Andersen MR, Grotkjaer T, Regueira TB, Nielsen J, Olsson L (2009) Studies of the production of fungal polyketides in Aspergillus nidulans by using systems biology tools. Appl Environ Microbiol 75(7), 2212-2220. Details PubMed

Panagiotou G, Grotkjaer T, Hofmann G, Bapat PM, Olsson L (2009) Overexpression of a novel endogenous NADH kinase in Aspergillus nidulans enhances growth. Metab Eng 11(1), 31-39. Details PubMed

Panagiotou G, Nielsen J (2009) Nutritional systems biology: definitions and approaches. Annu Rev Nutr 29, 329-339. Details PubMed

Salazar M, Vongsangnak W, Panagiotou G, Andersen MR, Nielsen J (2009) Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis. Mol Genet Genomics 282(6), 571-586. Details PubMed

Andersen MR, Vongsangnak W, Panagiotou G, Salazar MP, Lehmann L, Nielsen J (2008) A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species. Proc Natl Acad Sci U S A 105(11), 4387-4392. Details PubMed

Kouskoumvekaki I, Yang Z, Jónsdóttir SO, Olsson L, Panagiotou G (2008) Identification of biomarkers for genotyping Aspergilli using non-linear methods for clustering and classification. BMC Bioinformatics 9, 59. Details PubMed

Panagiotou G, Andersen MR, Grotkjaer T, Regueira TB, Hofmann G, Nielsen J, Olsson L (2008) Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans. PLOS One 3(12), e3847. Details PubMed

Panagiotou G, Pachidou F, Petroutsos D, Olsson L, Christakopoulos P (2008) Fermentation characteristics of Fusarium oxysporum grown on acetate. Bioresour Technol 99(15), 7397-7401. Details PubMed

Panagiotou G, Papadakis MA, Topakas E, Olsson L, Christakopoulos P (2008) Identification of NADH kinase activity in filamentous fungi and structural modelling of the novel enzyme from Fusarium oxysporum Process Biochemistry 43(10), 1114-1120. Details

Meijer S, Panagiotou G, Olsson L, Nielsen J (2007) Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Biotechnol Bioeng 98(2), 462-475. Details PubMed

Otero JM, Panagiotou G, Olsson L (2007) Fueling industrial biotechnology growth with bioethanol. Adv Biochem Eng Biotechnol 108, 1-40. Details PubMed

Panagiotou G, Kouskoumvekaki I, Jónsdóttir SO, Olsson L (2007) Monitoring novel metabolic pathways using metabolomics and machine learning: induction of the phosphoketolase pathway in Aspergillus nidulans cultivations Metabolomics 3(4), 503-516. Details

Panagiotou G, Olavarria R, Olsson L (2007) Penicillium brasilianum as an enzyme factory; the essential role of feruloyl esterases for the hydrolysis of the plant cell wall. J Biotechnol 130(3), 219-228. Details PubMed

Panagiotou G, Olsson L (2007) Effect of compounds released during pretreatment of wheat straw on microbial growth and enzymatic hydrolysis rates. Biotechnol Bioeng 96(2), 250-258. Details PubMed

Panagiotou G, Christakopoulos P, Grotkjaer T, Olsson L (2006) Engineering of the redox imbalance of Fusarium oxysporum enables anaerobic growth on xylose. Metab Eng 8(5), 474-482. Details PubMed

Panagiotou G, Granouillet P, Olsson L (2006) Production and partial characterization of arabinoxylan-degrading enzymes by Penicillium brasilianum under solid-state fermentation. Appl Microbiol Biotechnol 72(6), 1117-1124. Details PubMed

Panagiotou G, Christakopoulos P, Olsson L (2005) The influence of different cultivation conditions on the metabolome of Fusarium oxysporum. J Biotechnol 118(3), 304-315. Details PubMed

Panagiotou G, Christakopoulos P, Olsson L (2005) Simultaneous saccharification and fermentation of cellulose by Fusarium oxysporum F3—growth characteristics and metabolite profiling Enzyme and Microbial Technology 36(5-6), 693-699. Details

Panagiotou G, Christakopoulos P, Villas-Boas SG, Olsson L (2005) Fermentation performance and intracellular metabolite profiling of Fusarium oxysporum cultivated on a glucose-xylose mixture. Enzyme and Microbial Technology 36, 100-106. Details

Panagiotou G, Villas-Bôas SG, Christakopoulos P, Nielsen J, Olsson L (2005) Intracellular metabolite profiling of Fusarium oxysporum converting glucose to ethanol. J Biotechnol 115(4), 425-434. Details PubMed

Panagiotou G, Christakopoulos P (2004) NADPH-dependent D-aldose reductases and xylose fermentation in Fusarium oxysporum. J Biosci Bioeng 97(5), 299-304. Details PubMed

Panagiotou G, Kekos D, Macris BJ, Christakopoulos P (2003) Production of cellulolytic and xylanolytic enzymes by Fusarium oxysporum grown on corn stover in solid state fermentation. Industrial Crops and Products 18(1), 37-45. Details

Panagiotou G, Topakas E, Economou L, Kekos D, Macris BJ, Christakopoulos P (2003) Induction, purification, and characterization of two extracellular alpha-L-arabinofuranosidases from Fusarium oxysporum. Can J Microbiol 49(10), 639-644. Details PubMed

Panagiotou G, Kekos D, Macris BJ, Christakopoulos P (2002) Purification and characterisation of NAD+-dependent xylitol dehydrogenase from Fusarium oxysporum Biotechnology Letters 24(24), 2089-2092. Details