Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head
Phone: +49 3641 532-1525 Fax: +49 3641 532-2525 Email: christine.beemelmanns@leibniz-hki.de
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Charakterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
| Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
| 2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
| 2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
| 2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
| 2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
| 2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
| 2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
| 2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
| Since 2014 | Membership VAAM, FEMS and IUMS |
| Since 2014 | Membership Dechema |
| Since 2014 | Membership National Research Foundation of Korea |
| 2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
| 2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
| 2010-2011 | Postdoc fellowship from the DAAD |
| Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
| 2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
| 2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
| 2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
| 2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
| 2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
| 2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
| Since 2003 | Member of the GDCH |
| 2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
| 2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
(2018) Expanding the Rubterolone Family - Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans. Chemistry [Epub ahead of print] Details PubMed
(2018) Biosynthesis, Synthesis and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium ACS Chem. Biol. [Accepted] Details
(2018) Barnesin A, derivatives and uses thereof. EU patent application 2018 Details
(2017) Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett 19(5), 1000-1003. Details PubMed
(2017) Wie sich Bakterien schützen Nachrichten aus der Chemie 65(1), 21-25. (Review) Details Open Access
(2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2 Chem. Eur J 23(39), 9338-9345. Details PubMed
(2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed
(2017) Total synthesis and functional analysis of microbial signalling molecules. Chem Soc Rev 46(20), 6330-6344. Details PubMed
(2017) Bakterien-induzierte Morphogenese mariner Eukaryoten Wissenschaft BIOSpektrum 6/2017, 634-637. (Review) Details Open Access
(2017) Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org Lett 19(7), 1772-1775. Details PubMed
(2016) Natural products from microbes associated with insects. Beilstein J Org Chem 12, 314-327. Details PubMed Open Access
(2016) Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J. Am. Chem. Soc. 138(13), 4326-4329. Details PubMed
(2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed
(2016) Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1. J Nat Prod 79(12), 3072-3078. Details PubMed
(2016) A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT Natural Product Communications 4(11), 461-463. Details
(2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc. 4(1), e00003-16. Details PubMed
(2016) Bacteria regulate choanoflagellate development with lipid activators, inhibitors, and synergists Proc. Nat. Acad. Sci. USA 113(28), 7894-7899. Details PubMed
(2015) Evolution of a Short Route to Strychnine by Using the Samarium Diiodide-Induced Cascade Cyclization as a Key Step Chemistry - A European Journal 21(23), 8416-8425. Details PubMed
(2015) Strychnine as Target - Samarium Diiodide as Tool - A Personal Story The Chemical Record 15(5), 872-885. Details PubMed
(2015) A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth Bioorg. Med. Chem. Lett. 14(25), 2834-2836. Details PubMed
(2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed
(2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed
(2014) Synthesis of the rosette-inducing factor RIF-1 and analogs. J. Am. Chem. Soc. 136(29), 10210-10213. Details PubMed
(2014) Naphthalenones and isocoumarins from a Costa Rican fungus Xylariaceae sp. CR1546C Journal of Chemical Research 38(12), 722-725. Details
(2014) Natalamycin A, an ansamycin from a termite-associated Streptomyces sp Chem. Sci. 5(11), 4333-4338. Details PubMed
(2014) Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 67(1), 53-58. Details PubMed
(2013) Towards the core structure of Strychnos alkaloids using samarium diiodide-induced reactions of indole derivatives. Chemistry 19(52), 17801-17808. Details PubMed
(2012) Planar Chiral Disilanols and Diols as H-Bonding Asymmetric Organocatalysts Eur. J. Org. Chem. , 3373-3376. Details
(2011) Samarium diiodide induced cyclizations of γ-, δ- and ε-indolyl ketones: reductive coupling, intermolecular trapping, and subsequent transformations of indolines. Chemistry 17(35), 9720-9730. Details PubMed
(2011) Samarium diiodide induced ketyl-(het)arene cyclisations towards novel N-heterocycles. Chem Soc Rev 40(5), 2199-2210. Details PubMed
(2011) New Samarium Diiodide Induced Cyclizations Pure Appl. Chem. 83, 507-518. Details
(2010) Highly Diastereoselective Samarium Diiodide Induced Ketyl Cyclizations of Indole and Pyrrole Derivatives – Scope and Limitations. Eur J Org Chem 2010(14), 2716-2732. Details
(2010) A short formal total synthesis of strychnine with a samarium diiodide induced cascade reaction as the key step. Angew Chem Int Ed Engl 49(43), 8021-8025. Details PubMed
(2009) Highly diastereoselective samarium diiodide induced cyclizations of new 3-substituted indole derivatives. Org Biomol Chem 7(21), 4475-4480. Details PubMed
(2009) Various Synthetic Routes to a Gable-Like Bis(porphyrin) Constructed on a 1,10-Phenanthroline Chelate Eur. J. Org. Chem. , 2801-2805. Details
(2008) Catalytic asymmetric conjugate reduction with ethanol: A more reactive system Pd(II)–iPr-DUPHOS complex with molecular sieves 4A Journal of Organometallic Chemistry 693(5), 867-873. Details
