Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head
Phone: +49 3641 532-1525 Fax: +49 3641 532-2525 Email: christine.beemelmanns@leibniz-hki.de
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Characterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
| Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
| 2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
| 2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
| 2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
| 2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
| 2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
| 2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
| 2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
| Since 2014 | Membership VAAM, FEMS and IUMS |
| Since 2014 | Membership Dechema |
| Since 2014 | Membership National Research Foundation of Korea |
| 2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
| 2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
| 2010-2011 | Postdoc fellowship from the DAAD |
| Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
| 2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
| 2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
| 2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
| 2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
| 2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
| 2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
| Since 2003 | Member of the GDCH |
| 2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
| 2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
(2019) Stereoselective Cascade Cyclizations with Samarium Diiodide to Tetracyclic Indolines - Precursors of Fluorostrychnines and Brucine. Chemistry - European Journal [Accepted] Details PubMed
(2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420 Details Open Access PDF
(2019) Mechanistic Characterization of Three Sesquiterpene Synthases from the Termite-Associated Fungus Termitomyces Org. Biol. Chem. [Accepted] Details
(2019) Reviewing the taxonomy of Podaxis: opportunities for understanding extreme fungal lifestyles Fun. Biol. [Epub ahead of print] (Review) Details PubMed Open Access
(2019) Efomycins K and L from a Termite-associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin Front. Microbiol. [Accepted] Details
(2019) Stereoselective Synthesis of Unnatural (2S,3S)-6-Hydroxy-4-Sphingenine-Containing Sphingolipids Org Bio Chem [Accepted] Details Open Access
(2019) Disease-free monoculture farming by fungus-growing termites Sci Rep. 9(8819), 8819. Details Open Access
(2019) Ursprung und Funktionen der Sphingolipide Nachrichten aus der Chemie 67(2), 66-70. (Review) Details PubMed
(2019) Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis. Nutrients [Epub ahead of print] Details PubMed Open Access
(2018) Natural products from Actinobacteria associated with fungus-growing termites. Antibiotics 7(3), pii: E83. Details PubMed Open Access
(2018) Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS‐derived Pyrans. Chem Eur J 24(44), 11319-11324. Details PubMed
(2018) Tropolone natural products Nat. Prod. Rep [Epub ahead of print] Details PubMed Open Access
(2018) Precursor-directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins ChemBioChem 19(21), 2307-2311. Details PubMed
(2018) Natalenamides A-C, Cyclic Tripeptides from the Termite-associated Actinomadura sp. RB99 Molecules 23(11), pii: E3003. Details PubMed Open Access
(2018) Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana Org. Chem. Front. [Epub ahead of print] Details Open Access
(2018) Chemical Identification of Isoflavonoids from a Termite-Associated Streptomyces sp. RB1 and Their Neuroprotective Effects in Murine Hippocampal HT22 Cell Line. Int J Mol Sci 19(9), E2640. Details PubMed Open Access
(2018) The Inhibitory Effects of Cyclodepsipeptides from the Entomopathogenic Fungus Beauveria bassiana on Myofibroblast Differentiation in A549 Alveolar Epithelial Cells Molecules 23(10), pii: E2568. Details PubMed Open Access
(2018) Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67 Org.Chem. Front. [Epub ahead of print] Details Open Access
(2018) Biosynthesis, Synthesis and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium ACS Chem Biol 13(8), 1990-1995. Details PubMed
(2018) Role of chemical mediators in aquatic interactionas across the prokaryote eukaryote boundary J Chem Ecol [Accepted] (Review) Details PubMed
(2017) Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett 19(5), 1000-1003. Details PubMed
(2017) Wie sich Bakterien schützen Nachrichten aus der Chemie 65(1), 21-25. (Review) Details Open Access
(2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2 Chem. Eur J 23(39), 9338-9345. Details PubMed
(2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed
(2017) Total synthesis and functional analysis of microbial signalling molecules. Chem Soc Rev 46(20), 6330-6344. (Review) Details PubMed
(2017) Bakterien-induzierte Morphogenese mariner Eukaryoten Wissenschaft BIOSpektrum 2017(6), 634-637. (Review) Details Open Access
(2017) Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org Lett 19(7), 1772-1775. Details PubMed
(2016) Natural products from microbes associated with insects. Beilstein J Org Chem 12, 314-327. Details PubMed Open Access
(2016) Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J Am Chem Soc 138(13), 4326-4329. Details PubMed
(2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed
(2016) Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1. J Nat Prod 79(12), 3072-3078. Details PubMed
(2016) A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT Nat Prod Commun 4(11), 461-463. Details
(2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. Details PubMed
(2016) Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A 113(28), 7894-7899. Details PubMed
(2015) Evolution of a Short Route to Strychnine by Using the Samarium Diiodide-Induced Cascade Cyclization as a Key Step Chemistry - A European Journal 21(23), 8416-8425. Details PubMed
(2015) Strychnine as Target - Samarium Diiodide as Tool - A Personal Story The Chemical Record 15(5), 872-885. Details PubMed
(2015) A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth Bioorg. Med. Chem. Lett. 14(25), 2834-2836. Details PubMed
(2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed
(2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed
(2014) Synthesis of the rosette-inducing factor RIF-1 and analogs. J. Am. Chem. Soc. 136(29), 10210-10213. Details PubMed
(2014) Naphthalenones and isocoumarins from a Costa Rican fungus Xylariaceae sp. CR1546C Journal of Chemical Research 38(12), 722-725. Details
(2014) Natalamycin A, an ansamycin from a termite-associated Streptomyces sp Chem. Sci. 5(11), 4333-4338. Details PubMed
(2014) Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 67(1), 53-58. Details PubMed
(2013) Towards the core structure of Strychnos alkaloids using samarium diiodide-induced reactions of indole derivatives. Chemistry 19(52), 17801-17808. Details PubMed
(2012) Planar Chiral Disilanols and Diols as H-Bonding Asymmetric Organocatalysts Eur. J. Org. Chem. , 3373-3376. Details
(2011) Samarium diiodide induced cyclizations of γ-, δ- and ε-indolyl ketones: reductive coupling, intermolecular trapping, and subsequent transformations of indolines. Chemistry 17(35), 9720-9730. Details PubMed
(2011) Samarium diiodide induced ketyl-(het)arene cyclisations towards novel N-heterocycles. Chem Soc Rev 40(5), 2199-2210. Details PubMed
(2011) New Samarium Diiodide Induced Cyclizations Pure Appl. Chem. 83, 507-518. Details
(2010) Highly Diastereoselective Samarium Diiodide Induced Ketyl Cyclizations of Indole and Pyrrole Derivatives – Scope and Limitations. Eur J Org Chem 2010(14), 2716-2732. Details
(2010) A short formal total synthesis of strychnine with a samarium diiodide induced cascade reaction as the key step. Angew Chem Int Ed Engl 49(43), 8021-8025. Details PubMed
(2009) Highly diastereoselective samarium diiodide induced cyclizations of new 3-substituted indole derivatives. Org Biomol Chem 7(21), 4475-4480. Details PubMed
(2009) Various Synthetic Routes to a Gable-Like Bis(porphyrin) Constructed on a 1,10-Phenanthroline Chelate Eur. J. Org. Chem. , 2801-2805. Details
(2008) Catalytic asymmetric conjugate reduction with ethanol: A more reactive system Pd(II)–iPr-DUPHOS complex with molecular sieves 4A Journal of Organometallic Chemistry 693(5), 867-873. Details
