
Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head
Phone: +49 3641 532-1525 Fax: +49 3641 532-2525 Email: christine.beemelmanns@leibniz-hki.de
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Characterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
2020 | Dozentenpreis des Fonds der Chemischen Industrie |
2020 | Visiting Professor in Madison Wisconsin USA |
2019-2024 | ERC Starting GRant MORPHEUS |
2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
Since 2014 | Membership VAAM, FEMS and IUMS |
Since 2014 | Membership Dechema |
Since 2014 | Membership National Research Foundation of Korea |
2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
2010-2011 | Postdoc fellowship from the DAAD |
Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
Since 2003 | Member of the GDCH |
2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
(2020) Recent highlights of biosynthetic studies on marine natural products. Org Biomol Chem 19(1), 123-140. (Review) Details PubMed Open Access
(2020) Actinomadura rubteroloni sp. nov. and Actinomadura macrotermitis sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis. Int J Syst Evol Microbiol 70(10), 5255-5262. Details PubMed Open Access
(2020) Nocardia macrotermitis sp. nov. and Nocardia aurantia sp. nov., isolated from the gut of the fungus-growing termite Macrotermes natalensis. Int J Syst Evol Microbiol 70(10), 5226-5234. Details PubMed Open Access
(2020) Immunomodulatory function of antimicrobial peptide Ec-Hepcidin1 modulates the induction of inflammatory gene expression in primary cells of caspian trout (Salmo trutta caspius Kessler, 1877). Fish Shellfish Immunol 104, 55-61. Details PubMed Open Access PDF
(2020) Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols. Org Lett 22(7), 2634-2638. Details PubMed
(2020) Stereoselective construction of (E,Z)-1,3-dienes and its application in natural product synthesis. Adv Synth Catal 362, 1-2. (Review) Details
(2020) Xyloneside A: A new glycosylated incisterol derivative from Xylaria sp. FB. ChemBioChem 21(16), 2253-2258. Details PubMed Open Access PDF
(2020) Absolute configuration and corrected NMR assignment of 17-hydroxycyclooctatin, a fused 5-8-5 tricyclic diterpene. J Nat Prod 83(2), 354-361. Details PubMed
(2020) From Persian Gulf to Indonesia: Interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca). Sci Rep 10(1), 13048. Details PubMed Open Access PDF
(2020) Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF. Chem Sci 11, 5182-5190. Details Open Access PDF
(2020) Anti-adipogenic pregnane steroid from a hydractinia-associated fungus, Cladosporium sphaerospermum sp. SW67. Nat Prod Sci 26(3), 230-235. Details Open Access
(2020) Polyhalogenation of isoflavonoids by the termite-associated Actinomadura sp. RB99. J Nat Prod 83(10), 3102-3110. Details PubMed
(2020) Modular solid-phase synthesis of antiprotozoal barnesin derivatives. Org Lett 22(10), 3744-3748. Details PubMed
(2020) Targeted discovery of tetrapeptides and cyclic polyketide‐peptide hybrids from a fungal antagonist of farming termites. ChemBioChem 21(20), 2991-2996. Details PubMed Open Access PDF
(2020) Steptomyces smaragdinus sp. nov. isolated from the gut of fungus growing-termite Macrotermes natalensis. Int J Syst Evol Microbiol 70(11), 5806-5811. Details PubMed Open Access PDF
(2019) Stereoselective cascade cyclizations with samarium diiodide to tetracyclic indolines - precursors of fluorostrychnines and brucine. Chemistry 25(37), 8780-8789. Details PubMed
(2019) Metabolic pathway rerouting in Paraburkholderia rhizoxinica evolved long-overlooked derivatives of coenzyme F420. ACS Chem Biol 14(9), 2088-2094. Details PubMed PDF
(2019) Mechanistic characterization of three sesquiterpene synthases from the termite-associated fungus Termitomyces. Org Biol Chem 17(13), 3348-3355. Details PubMed
(2019) Reviewing the taxonomy of podaxis: Opportunities for understanding extreme fungal lifestyles. Fungal Biol 123(3), 183-187. (Review) Details PubMed Open Access PDF
(2019) Tropolone natural products. Nat Prod Rep 36(8), 1137-1155. Details PubMed
(2019) Efomycins K and L from a termite-associated Streptomyces sp. M56 and their putative biosynthetic origin. Front Microbiol 10, 1739. Details PubMed Open Access PDF
(2019) Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana. Org Chem Front 6, 162-166. Details
(2019) Hybrid polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and their putative biosynthetic origin. Mar Drugs 17(11), 606. Details PubMed Open Access PDF
(2019) Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids. Org Biomol Chem 17(29), 6964-6969. Details PubMed Open Access PDF
(2019) Disease-free monoculture farming by fungus-growing termites. Sci Rep 9(1), 8819. Details PubMed Open Access PDF
(2019) Biosynthesis of the redox cofactor mycofactocin comprises oligoglycosylation by MftF in Mycolicibacterium smegmatis. bioRxiv , Details Open Access PDF
(2019) Ursprung und Funktionen der Sphingolipide. Nachrichten aus der Chemie 67(2), 66-70. (Review) Details
(2019) Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67. Org Chem Front 6, 1084-1093. Details
(2019) Fridamycin A, a microbial natural product, stimulates glucose uptake without inducing adipogenesis. Nutrients 11(4), 765. Details PubMed Open Access PDF
(2018) Natural products from Actinobacteria associated with fungus-growing termites. Antibiotics 7(3), 83. Details PubMed Open Access
(2018) Expanding the rubterolone family: Intrinsic reactivity and directed diversification of PKS‐derived pyrans. Chem Eur J 24(44), 11319-11324. Details PubMed
(2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem 19(21), 2307-2311. Details PubMed
(2018) Natalenamides A-C, cyclic tripeptides from the termite-associated Actinomadura sp. RB99. Molecules 23(11), 3003. Details PubMed Open Access PDF
(2018) Chemical identification of isoflavonoids from a termite-associated Streptomyces sp. RB1 and their neuroprotective effects in murine hippocampal HT22 cell line. Int J Mol Sci 19(9), 2640. Details PubMed Open Access PDF
(2018) The inhibitory effects of cyclodepsipeptides from the entomopathogenic fungus Beauveria bassiana on myofibroblast differentiation in A549 alveolar epithelial cells. Molecules 23(10), 2568. Details PubMed Open Access PDF
(2018) Biosynthesis, synthesis and activities of barnesin A, a NRPS-PKS hybrid produced by an anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995. Details PubMed
(2018) Role of chemical mediators in aquatic interactionas across the prokaryote eukaryote boundary. J Chem Ecol 44(11), 1008-1021. (Review) Details PubMed Open Access PDF
(2017) Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett 19(5), 1000-1003. Details PubMed
(2017) Wie sich Bakterien schützen. Nachrichten aus der Chemie 65(1), 21-25. (Review) Details Open Access
(2017) Isolation, biosynthesis and chemical modifications of rubterolones A–F, rare tropolone alkaloids from Actinomadura sp. 5-2. Chem Eur J 23(39), 9338-9345. Details PubMed
(2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed
(2017) Total synthesis and functional analysis of microbial signalling molecules. Chem Soc Rev 46(20), 6330-6344. (Review) Details PubMed
(2017) Bakterien-induzierte Morphogenese mariner Eukaryoten Wissenschaft. BIOSpektrum 2017(6), 634-637. (Review) Details Open Access
(2017) Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org Lett 19(7), 1772-1775. Details PubMed
(2016) Natural products from microbes associated with insects. Beilstein J Org Chem 12, 314-327. Details PubMed Open Access
(2016) Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J Am Chem Soc 138(13), 4326-4329. Details PubMed
(2016) Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: A competitor of fungus-growing termite cultivars. Org Lett 18, 3338-3341. Details PubMed
(2016) Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1. J Nat Prod 79(12), 3072-3078. Details PubMed
(2016) A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT Nat Prod Commun 4(11), 461-463. Details
(2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. Details PubMed
(2016) Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A 113(28), 7894-7899. Details PubMed
(2015) Evolution of a Short Route to Strychnine by Using the Samarium Diiodide-Induced Cascade Cyclization as a Key Step Chemistry - A European Journal 21(23), 8416-8425. Details PubMed
(2015) Strychnine as Target - Samarium Diiodide as Tool - A Personal Story The Chemical Record 15(5), 872-885. Details PubMed
(2015) A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth Bioorg. Med. Chem. Lett. 14(25), 2834-2836. Details PubMed
(2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed
(2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed
(2014) Synthesis of the rosette-inducing factor RIF-1 and analogs. J. Am. Chem. Soc. 136(29), 10210-10213. Details PubMed
(2014) Naphthalenones and isocoumarins from a Costa Rican fungus Xylariaceae sp. CR1546C Journal of Chemical Research 38(12), 722-725. Details
(2014) Natalamycin A, an ansamycin from a termite-associated Streptomyces sp Chem. Sci. 5(11), 4333-4338. Details PubMed
(2014) Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo) 67(1), 53-58. Details PubMed
(2013) Towards the core structure of Strychnos alkaloids using samarium diiodide-induced reactions of indole derivatives. Chemistry 19(52), 17801-17808. Details PubMed
(2012) Planar Chiral Disilanols and Diols as H-Bonding Asymmetric Organocatalysts Eur. J. Org. Chem. , 3373-3376. Details
(2011) Samarium diiodide induced cyclizations of γ-, δ- and ε-indolyl ketones: reductive coupling, intermolecular trapping, and subsequent transformations of indolines. Chemistry 17(35), 9720-9730. Details PubMed
(2011) Samarium diiodide induced ketyl-(het)arene cyclisations towards novel N-heterocycles. Chem Soc Rev 40(5), 2199-2210. Details PubMed
(2011) New Samarium Diiodide Induced Cyclizations Pure Appl. Chem. 83, 507-518. Details
(2010) Highly Diastereoselective Samarium Diiodide Induced Ketyl Cyclizations of Indole and Pyrrole Derivatives – Scope and Limitations. Eur J Org Chem 2010(14), 2716-2732. Details
(2010) A short formal total synthesis of strychnine with a samarium diiodide induced cascade reaction as the key step. Angew Chem Int Ed Engl 49(43), 8021-8025. Details PubMed
(2009) Highly diastereoselective samarium diiodide induced cyclizations of new 3-substituted indole derivatives. Org Biomol Chem 7(21), 4475-4480. Details PubMed
(2009) Various Synthetic Routes to a Gable-Like Bis(porphyrin) Constructed on a 1,10-Phenanthroline Chelate Eur. J. Org. Chem. , 2801-2805. Details
(2008) Catalytic asymmetric conjugate reduction with ethanol: A more reactive system Pd(II)–iPr-DUPHOS complex with molecular sieves 4A Journal of Organometallic Chemistry 693(5), 867-873. Details