- Development and optimisation of biotechnological processes for natural products and proteins
- Ultra high throughput screening of natural product producers in microfluidic systems
- Development of technologies for the in vivo monitoring of bioprocess parameters
|Since 2004||Head of the Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena|
|1996-2004||Research assistant at the HKI|
|1994-1996||Postdoc of the working group of Prof. Dr. Andreas Plückthun, Dept. of Biochemistry, University Zurich, Schwitzerland, funded through EMBO Fellowship|
|1994||Dr. rer. nat. in mikrobiology, „magna cum laude“, Martin Luther University Halle-Wittenberg, Institut für Allgemeine Mikrobiologie|
|1989-1994||Scientific assistant at the Institut für Allgemeine Mikrobiologie at the Martin Luther University Halle-Wittenberg|
|1989||Diploma in biology at the Martin Luther Universiyt Halle-Wittenberg|
|1986-1989||Studies in biology at the Martin Luther University, Halle-Wittenberg|
|1984-1986||Studies in biology at the Ernst Moritz Arndt University, Greifswald|
Awards · Appointments · Scientific Activities
(2016) The glycolytic enzyme enolase represents a plasminogen-binding protein on the surface of a wide variety of medically important fungal species. Int J Med Microbiol 306(1), 59-68.
(2016) Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation. Amyloid 23(2), 76-85.
(2016) Draft genome sequences of fungus Aspergillus calidoustus. Genome Announc 4(2), e00102-16.
(2016) Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. Proc Natl Acad Sci U S A 113(20), 5604-5609.
(2016) Nanorough titanium surfaces reduce adhesion of Escherichia coli and Staphylococcus aureus via nano adhesion points Colloids Surf B Biointerfaces 145, 617-625.
(2016) Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides. Angew Chem Int Ed 55(16), 5081-5084.
(2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663.
(2014) Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies. Acta Neuropathol Commun 2:43,
(2013) Simultaneous analysis of the non-canonical amino acids norleucine and norvaline in biopharmaceutical-related fermentation processes by a new ultra-high performance liquid chromatography approach. Amino Acids 44(4), 1225-1231.
(2013) Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation. Microb Cell Fact 12, 116.
(2012) Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A 109(31), 12503-12508.
(2012) Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans. J Biotechnol 160(1-2), 64-71.
(2011) Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer's Aβ peptide. Biochem Biophys Res Commun 409(3), 385-388.
(2011) Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils. J Mol Biol 408(3), 529-540.
(2011) Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol 405(2), 341-348.
(2011) Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones. Chembiochem 12(12), 1836-1839.
(2011) Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryot Cell 10(1), 98-9109.
(2010) Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol 76(24), 8143-8149.
(2010) Production and derivate composition of trisporoids in extended fermentation of Blakeslea trispora. Appl Microbiol Biotechnol 88(1), 241-249.
(2010) Novel approach of high cell density recombinant bioprocess development: optimisation and scale-up from microliter to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures. Microb Cell Fact 9, 35.
(2009) Facile promoter deletion in Escherichia coli in response to leaky expression of very robust and benign proteins from common expression vectors. Microb Cell Fact 8, 8.
(2008) Interleukin-13 acts as an apoptotic effector on lung epithelial cells and induces pro-fibrotic gene expression in lung fibroblasts. Clin Exp Allergy 38(4), 619-628.
(2007) Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A 104(49), 19232-19237.
(2007) A dual expression platform to optimize the soluble production of heterologous proteins in the periplasm of Escherichia coli. Appl Microbiol Biotechnol 76(6), 1413-1422.
(2007) An online monitoring system based on a synthetic sigma32-dependent tandem promoter for visualization of insoluble proteins in the cytoplasm of Escherichia coli. Appl Microbiol Biotechnol 75(2), 397-406.
(2007) A fluorogenic substrate as quantitative in vivo reporter to determine protein expression and folding of tobacco etch virus protease in Escherichia coli. Protein Expr Purif 52(2), 478-484.