Interaction with the microbiota
The bacterial microbiota is essential in preventing C. albicans infections. The use of antibiotic therapy is a major predisposing factor for common mucosal C. albicans infections as well as systemic disease in patients with underlying diseases. In close collaboration with the Department of Microbial Pathogenicity Mechanisms we investigate the interplay between the bacterial microbiota and C. albicans. Specifically, we are interested in bacteria that antagonize pathogenicity and can prevent disease. We study the mechanisms imposed by the bacteria upon the fungus that drive it to its commensal nature.
(2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15.
(2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), dmm039719.
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396.
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Dr. Mark S Gresnigt
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