Interaction with the microbiota

The bacterial microbiota is essential in preventing C. albicans infections. The use of antibiotic therapy is a major predisposing factor for common mucosal C. albicans infections as well as systemic disease in patients with underlying diseases. In close collaboration with the Department of Microbial Pathogenicity Mechanisms we investigate the interplay between the bacterial microbiota and C. albicans. Specifically, we are interested in bacteria that antagonize pathogenicity and can prevent disease. We study the mechanisms imposed by the bacteria upon the fungus that drive it to its commensal nature. 

Candida albicans and Lactobacillus rhamnosus interacting on intestinal epithelial cells
Publications

Kumamoto CA, Gresnigt MS, Hube B (2020) The gut, the bad and the harmless: Candida Albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol 56, 7-15. PubMed

Graf K, Last A, Gratz R, Allert S, Linde S, Westermann M, Gröger M, Mosig AS, Gresnigt MS, Hube B (2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), dmm039719. PubMed Open Access PDF

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS (2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396. PubMed

Staff
Raquel Alonso-Román

Raquel Alonso-Román

Doctoral researcher

Phone: +49 3641 532-1157 Email: raquel.roman@leibniz-hki.de

Mark S Gresnigt

Dr. Mark S Gresnigt

Head

Phone: +49 3641 532-1305 Email: mark.gresnigt@leibniz-hki.de

Antonia Last

Antonia Last

Doctoral researcher

Phone: +49 3641 532-1595 Email: antonia.last@leibniz-hki.de

Marisa Valentine

Marisa Valentine

Doctoral Researcher

Phone: +49 3641 532-1159 Email: marisa.valentine@leibniz-hki.de