(Bio-)Synthesis of Bacterial Natural Products
Bacteria biosynthesize a plethora of structurally diverse secondary metabolites. These compounds are particularly interesting due to their typically potent biological activities. We are interested in their isolation and structure elucidation as well as in their biosynthesis. To this end, we use a combination of molecular biological methods and bioinformatics tools.
We also perform total syntheses of novel active compounds, since often only minute amounts are produced by the respective microorganisms. Moreover, we synthesize derivatives for structure-activity-relationship studies.
(2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763.
(2018) Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic Nonribosomal Peptide Synthetase. Cell Chem Biol 25(6), 659-665.
(2017) Versatile synthesis of the signaling peptide glorin Beilstein J Org Chem 13, 247-250.
(2017) Lysinibacillus fusiformis M5 induces increased complexity in Bacillus subtilis 168 colony biofilms via hypoxanthine. J Bacteriol 199(22), e00204-e00217.
(2017) Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin ACS Chem Biol 12(10), 2498-2502.
(2016) Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed 55(31), 8944-8947.