(2023)
A mushroom P450-monooxygenase enables regio- and stereoselective biocatalytic synthesis of epoxycyclohexenones.
Angew Chem Intl Ed 62(49),
e202313817.
Curriculum vitae
Main Research Areas
- Biochemical and genetic basis of natural product biosynthesis of basal fungi (early-diverging fungi, especially mucoromycetes und zoopagomycetes)
- pharmaceutical application and ecological significance of fungal natural products
- alternative, non-canonical strategies of fungal natural product biosynthesis
Professional Career
| since 2024 | Habilitated lecturer („Privatdozent“) at the Institute for Pharmacy, Friedrich-Schiller-University, Jena, Germany |
| 2017-2024 | State doctorate (Habilitation) in pharmaceutical microbiology at the Friedrich-Schiller-University Jena, Germany |
| 2015-2017 | Postdoctoral, Institute Pasteur, Paris, France |
| 2009-2015 | Doctoral thesis (Dr. rer. nat.) in biochemistry at the Friedrich-Schiller-University Jena and the Hans-Knöll-Institute, Jena, Germany |
| 2003-2009 | Diploma in biochemistry/molecular biology at the Friedrich-Schiller-University Jena, Germany |
Publications
(2022)
Genetic survey of Psilocybe natural products.
ChemBioChem 23(14),
e202200249.
(2022)
Blue light-dependent pre-mRNA splicing controls pigment biosynthesis in the mushroom Terana caerulea.
Microbiol Spectr 10(5),
e0106522.
(2022)
Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor.
Angew Chem Int Ed 61(24),
e202116142.
(2022)
The ketosynthase domain controls chain length in mushroom oligocyclic polyketide synthases.
ChemBioChem 24(3),
e202200649.
(2022)
Regulation of the leucine metabolism in Mortierella alpina.
J Fungi (Basel) 8(2),
196.
(2022)
Macrophage-targeting oligopeptides from Mortierella alpina.
Chem Sci 13(31),
9091-9101.
(2021)
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota.
Nat Prod Rep 38(4),
702-722.
(Review)
(2021)
Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis.
Environ Microbiol 23(8),
4360-4371.
(2020)
S-adenosyl-L-methionin salvage impacts psilocybin formation in 'magic' mushrooms.
ChemBioChem 21(9),
1364-1371.
