Dirk Hoffmeister

Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.de

Curriculum vitae

Main Research Areas

Quinone synthetases and related enzymes
Polyketide synthases of basidiomycetes
Biosynthesis of psilocybin
Natural products of the genus Psilocybe

Professional Career

2014-	Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena
2009-2014	Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena
2007-2009	Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008	Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg
2004-2007	Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg
2002-2004	Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)
2002	Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg
1998	Diploma in biology at the Eberhard-Karls-University, Tübingen

Awards · Appointments · Scientific Activities

Since 2020	Head of the Institute for Pharmacy, FSU Jena
2016-2019	Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena
2013-2016	Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).

Publications

Schäfer E, Seibold PS, Bartram S, Trottmann F, Hänsch V, Gressler M, Chadeayne A, Hertweck C, O'Connor S, Hoffmeister D (2023) A "Magic Mushroom" multi-product sesquiterpene synthase. ChemBioChem 24(21), e202300511.

Details

Seibold PS, Lawrinowitz S, Raztsou I, Gressler M, Arndt HD, Stallforth P, Hoffmeister D (2023) Bifurcate evolution of quinone synthetases in basidiomycetes. Fungal Biol Biotechnol 10(1), 14.

Details

Wein P, Dornblut K, Herkersdorf S, Krüger T, Molloy EM, Brakhage AA, Hoffmeister D, Hertweck C (2023) Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease. mBio 14(4), e0078723.

Details

Yang YL, Zhou M, Yang L, Gressler M, Rassbach J, Wurlitzer JM, Zeng Y, Gao K, Hoffmeister D (2023) A mushroom P450-monooxygenase enables regio- and stereoselective biocatalytic synthesis of epoxycyclohexenones. Angew Chem Intl Ed 62(49), e202313817.

Details

Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249.

Details

Ezediokpu MN, Krause K, Kunert M, Hoffmeister D, Boland W, Kothe E (2022) Ectomycorrhizal influence on the dynamics of sesquiterpene release by Tricholoma vaccinum. J Fungi (Basel) 8(6), 555.

Details

Kreuzenbeck NB, Seibel E, Schwitalla JW, Fricke J, Conlon BH, Schmidt S, Hammerbacher A, Köllner TG, Poulsen M, Hoffmeister D, Beemelmanns C (2022) Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites. mSystems 7(1), e0121421.

Details

Lawrinowitz S, Wurlitzer JM, Weiss D, Arndt, HD, Kothe E, Gressler M, Hoffmeister D (2022) Blue light-dependent pre-mRNA splicing controls pigment biosynthesis in the mushroom Terana caerulea. Microbiol Spectr 10(5), e0106522.

Details

Lenz C, Dörner S, Trottmann F, Hertweck C, Sherwood A, Hoffmeister D (2022) Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines. ChemBioChem 23(13), e202200183.

Details

Löhr NA, Eisen F, Thiele W, Platz L, Motter J, Hüttel W, Gressler M, Müller M, Hoffmeister D (2022) Unprecedented mushroom polyketide synthases produce the universal anthraquinone precursor. Angew Chem Int Ed 61(24), e202116142.

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