Dirk Hoffmeister

Dirk Hoffmeister

Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.de

Curriculum vitae

Main Research Areas
  • Quinone synthetases and related enzymes
  • Polyketide synthases of basidiomycetes
  • Biosynthesis of psilocybin
  • Natural products of the genus Psilocybe
Professional Career
2014- Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena
2009-2014 Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena
2007-2009 Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008 Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg
2004-2007 Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg
2002-2004 Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)
2002 Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg
1998 Diploma in biology at the Eberhard-Karls-University, Tübingen
Awards · Appointments · Scientific Activities
Since 2020 Head of the Institute for Pharmacy, FSU Jena
2016-2019 Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena
2013-2016 Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).

Publications

Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D (2020) Scalable hybrid synthetic/biocatalytic route to psilocybin. Chem Eur J 37(26), 8281-8285.
Details
PubMed Open Access PDF Paper
Lenz C, Wick J, Braga D, Garcia-Altares M, Lackner G, Hertweck C, Gressler M, Hoffmeister D (2020) Injury-triggered blueing reactions of Psilocybe "magic" mushrooms. Angew Chem Int Ed 59(4), 1450-1454.
Details
PubMed Open Access PDF Paper
Seibold PS, Lenz C, Gressler M, Hoffmeister D (2020) The Laetiporus polyketide synthase LpaA produces a series of antifungal polyenes. J Antibiot 73(10), 711-720.
Details
PubMed Open Access PDF Paper
Shah F, Gressler M, Nehzati S, Op De Beeck M, Gentile L, Hoffmeister D, Persson P, Tunlid A (2020) Secretion of iron(III)-reducing metabolites during protein acquisition by the ectomycorrhizal fungus Paxillus involutus. Microorganisms 9(1), 35.
Details
PubMed Open Access PDF Paper
Baccile JA, Le HH, Pfannenstiel BT, Bok JW, Gomez C, Brandenburger E, Hoffmeister D, Keller NP, Schroeder FC (2019) Diketopiperazine formation in fungi requires dedicated cyclization and thiolation domains. Angew Chem Int Ed 58(41), 14589-14593.
Details
PubMed
Baldeweg F, Hoffmeister D, Nett M (2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria. Nat Prod Rep 36(2), 307-325. (Review)
Details
PubMed
Dörfer M, Gressler, M, Hoffmeister D (2019) Diversity and bioactivity of Armillaria sesquiterpene aryl ester natural products. Mycol Prog 18(8), 1027-1037.
Details
Open Access PDF Paper
Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D (2019) Melleolides impact fungal translation via elongation factor 2. Org Biomol Chem 17(19), 4906-4916.
Details
PubMed
Fricke J, Lenz C, Wick J, Blei F, Hoffmeister D (2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. (Review)
Details
PubMed Open Access
Fricke J, Sherwood A, Kargbo R, Orry A, Blei F, Naschberger A, Rupp B, Hoffmeister D (2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20(22), 2824-2829.
Details
PubMed

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