(2022)
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead.
Nat Chem 14(8),
884-890.
Dr Hajo Kries
Biosynthetic Design of Natural Products · Head +49 3641 532 1735 hajo.kries@leibniz-hki.deCurriculum vitae
Professional Career
| 2023 | Substitute Professor W3 Organic Chemistry I, University of Bayreuth |
| since 2016 | Junior Group Leader, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena |
| 2014-2016 | Postdoc, John Innes Centre, Norwich (UK), with Prof. Sarah E. O'Connor |
| 2009-2014 | PhD "Tailor-made biocatalysts by enzyme design, redesign, and directed evolution" at ETH Zurich with Prof. Donald Hilvert |
| 2007-2009 | MSc in Chemistry, ETH Zurich |
| 2006-2007 | BSc in Biochemistry, University of Geneva |
| 2003-2006 | Studies of Biochemistry, University of Jena |
| 2002 | Abitur at the Gymnasium Heide-Ost |
Awards · Appointments · Scientific Activities
| 2021 | Max Buchner Fellowship, DECHEMA |
| 2020 | Medac Research Prize |
| 2019 | FCI material cost allowances |
| 2017-2019 | Fellowship of the Daimler and Benz Foundation |
| 2015-2016 | Marie Skłodowska-Curie postdoctoral fellowship (H2020), project 658155 |
| 2015 | Friedrich-Weygang-Preis, awarded by the Max-Bergmann-Kreis |
| 2015 | ETH Medal for the PhD thesis |
| 2014-2015 | Early Postdoc.Mobility fellowship of the Swiss National Science Foundation (SNSF) |
| 2011-2014 | PhD Fellowship of the Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI) |
| 2010-2012 | PhD Fellowship of the German Academic Scholarship Foundation |
| 2008-2009 | Oskar Jeger Fellowship for master studies (ETH Zurich) |
| 2008 | Novartis Master Fellowship |
| 2007-2009 | DAAD grant for foreign studies |
| 2005-2009 | Fellowship of the German Academic Scholarship Foundation |
Publications
(2022)
Macrophage-targeting oligopeptides from Mortierella alpina.
Chem Sci 13(31),
9091-9101.
(2021)
Engineered nonribosomal peptide synthetase shows opposite amino acid loading and condensation specificity.
ACS Catal 11(14),
8692-8700.
(2020)
Engineering DNA-templated nonribosomal peptide synthesis.
Cell Chem Biol 28(2),
221-227.
(2020)
Contribution of oxyanion stabilization to Kemp eliminase efficiency.
ACS Catal 10(8),
4460-4464.
(2020)
Sulfonium acids loaded onto an unusual thiotemplate assembly line construct the cyclopropanol warhead of a Burkholderia virulence factor.
Angew Chem Int Ed 59(32),
13511-13515.
(2020)
Bacterial-like nonribosomal peptide synthetases produce cyclopeptides in the zygomycetous fungus Mortierella alpina.
Appl Env Microbiol 87(3),
e02051-20.
(2019)
Emergence of a negative activation heat capacity during evolution of a designed enzyme.
J Am Chem Soc 141(30),
11745-11748.
(2019)
Structure elucidation of the syringafactin lipopeptides provides insight in the evolution of nonribosomal peptide synthetases.
Chem Sci 10(48),
10979-10990.
(2019)
Unleashing the potential of ribosomal and nonribosomal peptide biosynthesis.
Biochemistry 58(2),
73-74.
(Review)
