(2024)
A highly conserved tRNA modification contributes to C. albicans filamentation and virulence.
Microbiol Spectr 12(5),
e0425522.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2023)
The role of host and fungal factors in the commensal-to-pathogen transition of Candida albicans.
Curr Clin Micro Rpt 10(2),
55-65.
(Review)
(2023)
Mouse models of Mucormycosis.
Methods Mol Biol 2667,
181-196.
(Review)
(2023)
Soluble enolase 1 of Candida albicans and Aspergillus fumigatus stimulates human and mouse B cells and monocytes.
J Immunol 211(5),
804-815.
(2023)
Escherichia coli nissle 1917 antagonizes Candida albicans growth and protects intestinal cells from C. albicans-mediated damage.
Microorganisms 11(8),
1929.
(2023)
Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation.
Neuropharmacology 235,
109568.
(Review)
(2023)
Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging.
Aging Cell 22(7),
e13856.
(2022)
Systemic Candidiasis in mice: New insights from an old model.
Front Fungal Biol 3,
940884.
(Review)
(2022)
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Nat Commun 13(1),
1880.
(2022)
Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection.
Front Cell Infect Microbiol 12,
866416.
