(2024)
Analysis of the valgamicin biosynthetic pathway reveals a general mechanism for cyclopropanol formation across diverse natural product scaffolds.
ACS Chem Biol 19(3),
660-668.
Dr Hajo Kries
Biosynthetic Design of Natural Products · Head +49 3641 532 1735 hajo.kries@leibniz-hki.deCurriculum vitae
Professional Career
| 2023 | Substitute Professor W3 Organic Chemistry I, University of Bayreuth |
| since 2016 | Junior Group Leader, Leibniz Institute for Natural Product Research and Infection Biology (Hans-Knöll-Institute), Jena |
| 2014-2016 | Postdoc, John Innes Centre, Norwich (UK), with Prof. Sarah E. O'Connor |
| 2009-2014 | PhD "Tailor-made biocatalysts by enzyme design, redesign, and directed evolution" at ETH Zurich with Prof. Donald Hilvert |
| 2007-2009 | MSc in Chemistry, ETH Zurich |
| 2006-2007 | BSc in Biochemistry, University of Geneva |
| 2003-2006 | Studies of Biochemistry, University of Jena |
| 2002 | Abitur at the Gymnasium Heide-Ost |
Awards · Appointments · Scientific Activities
| 2021 | Max Buchner Fellowship, DECHEMA |
| 2020 | Medac Research Prize |
| 2019 | FCI material cost allowances |
| 2017-2019 | Fellowship of the Daimler and Benz Foundation |
| 2015-2016 | Marie Skłodowska-Curie postdoctoral fellowship (H2020), project 658155 |
| 2015 | Friedrich-Weygang-Preis, awarded by the Max-Bergmann-Kreis |
| 2015 | ETH Medal for the PhD thesis |
| 2014-2015 | Early Postdoc.Mobility fellowship of the Swiss National Science Foundation (SNSF) |
| 2011-2014 | PhD Fellowship of the Stipendienfonds der Schweizerischen Chemischen Industrie (SSCI) |
| 2010-2012 | PhD Fellowship of the German Academic Scholarship Foundation |
| 2008-2009 | Oskar Jeger Fellowship for master studies (ETH Zurich) |
| 2008 | Novartis Master Fellowship |
| 2007-2009 | DAAD grant for foreign studies |
| 2005-2009 | Fellowship of the German Academic Scholarship Foundation |
Publications
(2024)
Controlling substrate- and stereospecificity of condensation domains in nonribosomal peptide synthetases.
ACS Chem Bio 19(3),
599-606.
(2023)
Novel biocatalysts from specialized metabolism.
Angew Chem Int Ed Engl 63(4),
e202309284.
(Review)
(2023)
Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S.
RSC Chem Biol 4(9),
692-697.
(2023)
Analysing megasynthetase mutants at high throughput using droplet microfluidics.
Chembiochem 24(24),
e202300680.
(2023)
Directed evolution of piperazic acid incorporation by a nonribosomal peptide synthetase.
Angew Chem Int Ed Engl 62(35),
e202304843.
(2023)
Biomimetic engineering of nonribosomal peptide synthesis.
Biochem Soc Trans 51(4),
1521-1532.
(Review)
(2022)
Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase.
ACS Chem Biol 17(9),
2382-2388.
(2022)
Total synthesis and functional evaluation of IORs, sulfonolipid-based inhibitors of cell differentiation in Salpingoeca rosetta.
Angew Chem Int Ed 61(41),
e202209105.
(2022)
Defining a nonribosomal specificity code for design.
bioRxiv
[Preprint]
