Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase.

He J, Müller M, Hertweck C (2004) Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase. J Am Chem Soc 126(51), 16742-16743. PubMed

Abstract

The polyketide antibiotic aureothin, produced by Streptomyces thioluteus, is equipped with a rare exomethylene-tetrahydrofuran moiety. Cloning, heterologous expression, and inactivation experiments reveal that AurH, a bifunctional cytochrome P450 monooxygenase, is required and sufficient for the stereoselective synthesis of the furan ring, involving the subsequent formation of two new C-O bonds.

Involved Units and Groups
HKI-Authors
Identifier

PMID: 15612710