Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction.

Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore BS (2004) Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. Chem Biol 11(4), 461-468. PubMed

Abstract

Heterologous expression and mutagenesis of the enterocin type II polyketide synthase (PKS) system suggest for the first time that the association of an extended set of proteins and substrates is needed for the effective production of the enterocin-wailupemycin polyketides. In the absence of its endogenous ketoreductase (KR) EncD in either the enterocin producer

Involved Units and Groups
HKI-Authors
Identifier

PMID: 15123240