Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic.

Gomes PB, Nett M, Dahse HM, Hertweck C (2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464. PubMed

Abstract

Chemical profiling of a Streptomyces griseus strain isolated from an old building with moisture damage led to the discovery of two novel phenoxazinones, chandrananimycin D and pitucamycin , along with the known grixazone B. Pitucamycin represents an unprecedented hybrid molecule composed of a phenoxazinone and an enaminomycin-like epoxyquinone moiety.

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doi: 10.1021/np100344u PMID: 20715808