A genomic approach to the cryptic secondary metabolome of the anaerobic world.

Letzel AC, Pidot SJ, Hertweck C (2013) A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat Prod Rep 30(3), 392-428. PubMed

Abstract

A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

Involved Units and Groups
HKI-Authors
Identifier

doi: 10.1039/c2np20103h PMID: 23263685