Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors.

Wangun HV, Härtl A, Tam Kiet T, Hertweck C (2006) Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. Org Biomol Chem 4(13), 2545-2548. PubMed

Abstract

By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp.

Involved Units and Groups
HKI-Authors
Identifier

PMID: 16791316