Farinamycin, a quinazoline from Streptomyces griseus.
(2011) Farinamycin, a quinazoline from Streptomyces griseus. J Nat Prod 74(10), 2265-2268.
The metabolic potential of a Streptomyces griseus strain was investigated under various cultivation conditions. After fermentation in a flour-based medium, a new quinazoline metabolite, farinamycin (1), could be isolated from the bacterium, which was previously known only for the production of phenoxazinone antibiotics. The structure of 1 illuminates the biosynthetic versatility of S. griseus, which assembles a defined set of building blocks into structurally diverse natural products.
doi: 10.1021/np2002513 PMID: 21939253