A family of multicyclic indolosesquiterpenes from a bacterial endophyte.
(2011) A family of multicyclic indolosesquiterpenes from a bacterial endophyte. Org Biomol Chem 9(11), 4029-4031.
Three novel indolosesquiterpenes, xiamycin B (1b), indosespene (2), and sespenine (3), along with the known xiamycin A (1a) were isolated from the culture broth of Streptomyces sp. HKI0595, a bacterial endophyte of the widespread mangrove tree Kandelia candel. Agar diffusion assays revealed moderate to strong antimicrobial activities against several bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, while no cytotoxicity against human tumor cell lines was observed. Together with the previously reported oridamycin, the endophyte metabolites represent the first indolosesquiterpenes isolated from prokaryotes.
doi: 10.1039/c1ob05283g PMID: 21528153