Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination.

Gebhardt P, Gräfe U, Möllmann U, Hertweck C (2005) Semisynthetic preparation of leucomycin derivatives: introduction of aromatic side chains by reductive amination. Mol Divers 9(1-3), 27-32. PubMed

Abstract

A small library of leucomycin A7 derivatives was prepared by NaCNBH3/ZnCl2-mediated reductive amination of the C18 aldehyde moiety with a variety of lipophilic benzylamines and tested for antibiotic activity.

Involved Units and Groups
HKI-Authors
Identifier

PMID: 15789548